Publications by authors named "Jia Min Li"
Changes in source contributions to the oxidative potential of PM in urban Xiamen, China.
J Environ Sci (China)
March 2025
Article Synopsis
- - The study analyzed the chemical composition and oxidative potential of particulate matter (PM) in Xiamen, China, comparing data from 2017/2018 and 2022. While PM mass concentration decreased by 55%, the volume-normalized oxidative potential (DTT) only decreased by 38%, but mass-normalized DTT increased by 44%.
- - Seasonal trends showed higher PM levels in winter, but not for DTT; also, a significant drop in DTT activity was observed after adding EDTA, indicating that water-soluble metals were key contributors to DTT in the area.
- - Various sources of PM affected the DTT levels differently: vehicle emissions, coal and biomass burning, and ship emissions
Article Synopsis
- Sleep deprivation is linked to cognitive impairment, and kaempferol (KMP) shows potential in alleviating these effects due to its anti-inflammatory and anti-apoptotic properties.
- Experiments demonstrated that KMP effectively reduced cognitive impairment in sleep-deprived mice by lowering astrocyte activation and microglia proliferation in the hippocampus.
- KMP enhances synaptic function and improves memory by influencing the MAPK pathway, as indicated by increased expression of certain receptor proteins and improved neurotransmitter transmission.
Article Synopsis
- The study presents a new method for combining 2-isocyanobiaryls with dialkyl(aryl)disulfides using visible light, making the process more environmentally friendly.
- This technique results in the formation of 6-organoylthiophenanthridines, which can have a variety of different functional groups.
- The process is efficient, yielding good to excellent results without the need for oxidants, bases, or transition metals, making it more sustainable and atom-efficient.
Article Synopsis
- Oxidative potential (OP) measures how particulate matter (PM) can create harmful reactive oxygen species (ROS) and varies by particle size, which affects health risks.
- A study conducted in Xiamen, China, from August 2020 to September 2021 analyzed size-segregated PM, revealing seasonal variations in OP, with the highest levels in spring and the lowest in summer, driven by interactions of transition metals and organics.
- The research found that the respiratory tract deposition model showed that a significant percentage of OP and toxic elements deposited in the airways pose health risks, indicating a need for attention on coarse particles from non-exhaust emissions.
Article Synopsis
- The study examines how the stressful conditions of the hospitality industry during COVID-19 impact hotel employees' work passion and emotional labor strategies.
- Using theories related to job resources, researchers conducted a survey among 206 frontline employees in China's five-star hotels to understand the connections between work passion, emotional labor, emotional expression, and service quality.
- Findings reveal that emotional labor acts as a mediator linking work passion to emotional expression, which then influences service quality during the pandemic.
Article Synopsis
- * Different regulated cell death (RCD) mechanisms, like apoptosis and autophagy, play crucial roles in the progression of cardiomyopathies and are associated with poor health outcomes.
- * Understanding the molecular mechanisms of RCD is essential to elucidate cardiomyopathy development and may lead to targeted therapies that address these cell death pathways.
Article Synopsis
- * The research found that PML levels are significantly higher in fibrotic cardiac tissue and that it influences the activation of fibroblasts when treated with TGF-β1, a factor that promotes fibrosis.
- * Additionally, the study highlights the interaction between PML and the protein p53, showing that p53 helps regulate PML expression and that PML can protect p53 from degradation, indicating a potential new target for treating cardiac fibrosis.
Article Synopsis
- The study investigates how using multiple b-values in Diffusion-weighted imaging (DWI) improves imaging quality and diagnostic accuracy for breast lesions compared to conventional methods.
- It involves 41 patients with benign tumors and 38 with malignant tumors, analyzing various parameters to determine their diagnostic performance using statistical methods.
- The findings suggest that a specific multiparametric combination (ADC-ADC) provides the best results for distinguishing between benign and malignant breast lesions, with notable sensitivity and specificity outcomes.
Article Synopsis
- The study investigates how vitamin D levels affect the relationship between particulate matter (PM) exposure and blood lipid levels in young, healthy adults.
- Conducted in Guangzhou, China, the research included 88 participants and analyzed various sizes of PM alongside serum lipids and vitamin D concentrations over five weeks.
- Findings reveal that lower vitamin D levels (under 15 ng/mL) were linked to significant increases in triglycerides and low-density lipoprotein cholesterol with higher PM exposure, while these associations were not significant in those with higher vitamin D levels (15 ng/mL or more).
Circulating Irisin Level as a Biomarker for Pure Aortic Stenosis and Aortic Valve Calcification.
J Cardiovasc Transl Res
April 2023
Irisin, a myokine mainly secreted by skeletal and cardiac muscles, is actively involved in cardiovascular diseases. However, whether irisin is associated with aortic stenosis remains unknown. Two hundred ninety-three severe AS patients who underwent transcatheter aortic valve implantation were enrolled and followed-up for 35 months on average.
View Article and Find Full Text PDFLong noncoding RNA lincsc5d regulates hepatic cholesterol synthesis by modulating sterol C5 desaturase in large yellow croaker.
Comp Biochem Physiol B Biochem Mol Biol
January 2023
Article Synopsis
- A study was conducted to see how long noncoding RNA (lncRNA) affects cholesterol metabolism in large yellow croaker fish when fed different types of oils (fish oil, soybean oil, olive oil, and palm oil).
- Results indicated that olive oil and palm oil diets led to higher cholesterol levels in the fish's liver compared to fish oil diets, with specific pathways like steroid biosynthesis showing significant changes.
- A novel lncRNA named lincsc5d, associated with the cholesterol synthase gene sc5d, was discovered and found to be more prevalent in the tissues of fish fed with soybean, olive, and palm oils, suggesting their role in increasing cholesterol synthesis.
Article Synopsis
- The study investigates the potential of retinol binding protein 4 (RBP4) as a predictive biomarker for hyperuricemia in the general population, an area that has seen limited research previously.
- Conducted as a cross-sectional survey in 2018 with 2,303 participants, the results showed a significant correlation between high serum RBP4 levels and an increased risk of hyperuricemia, with the highest RBP4 quartile having an odds ratio of 7.9.
- The optimal predictive model for hyperuricemia included RBP4 and several other factors, yielding an area under the ROC curve of 0.804, indicating that RBP4 is
Article Synopsis
- Dietary l-carnitine (LC) helps reduce fat in the liver and improves lipid metabolism when added to a high-fat diet in fish.
- The study on large yellow croaker showed that LC supplementation not only lowered total liver lipids and triglycerides but also boosted antioxidant capacity and relieved liver damage.
- LC enhanced mitochondrial function and reduced indicators of endoplasmic reticulum stress, demonstrating its potential to promote fatty acid oxidation while mitigating fat-related stress in the liver.
Article Synopsis
- The study investigated the prognostic value of N-terminal pro-C-type natriuretic peptide (NT-proCNP) in predicting survival rates after transcatheter aortic valve replacement (TAVR), a procedure often performed on elderly patients with heart conditions.
- The analysis included 309 patients over a median follow-up of 32 months, revealing that higher NT-proCNP levels and higher Society of Thoracic Surgeons (STS) scores were both linked to increased mortality risks.
- NT-proCNP demonstrated better predictive power than NT-proBNP, especially in patients with left ventricular ejection fraction (LVEF) below 50%, indicating its potential use in clinical risk assessments for TAVR patients.
A hybrid variable selection and modeling strategy for the determination of target compounds in different spectral datasets.
Spectrochim Acta A Mol Biomol Spectrosc
July 2022
Article Synopsis
- The paper introduces a hybrid technique that combines interval partial least squares (iPLS) and gradient descent (GD) to create quantitative models for analyzing target compounds in different spectral data.
- The iPLS method is utilized for selecting the best variables, while the GD algorithm is employed to build models with these selected variables, optimizing factors like interval number and learning rate for better accuracy.
- The effectiveness of this new iPLS-GD method is tested on three spectral datasets (NIR, H NMR, and EEM), showing it outperforms traditional methods in both modeling and predictive capabilities for identifying compounds in complex samples.
Article Synopsis
- Soluble Klotho (sKL) is linked to insulin resistance, which plays a significant role in the development of diabetic cardiomyopathy (DCM).
- This study utilized a mouse model induced by a high-fat diet and streptozotocin to explore how sKL regulates DCM and its underlying mechanisms.
- Overexpressing sKL improved insulin resistance and cardiac function, reducing inflammation and fibrosis in diabetic mice, suggesting potential therapeutic benefits for DCM in humans.
Exploring the Potential Mechanism of Shennao Fuyuan Tang for Ischemic Stroke Based on Network Pharmacology and Molecular Docking.
Evid Based Complement Alternat Med
September 2021
Article Synopsis
- - The study utilizes various databases and analysis tools to identify biologically active components and potential targets of SNFYT (a traditional Chinese medicine) related to the treatment of ischemic stroke (IS).
- - A total of 95 active components and 143 candidate targets were identified, leading to the construction of SNFYT-component-target and protein-protein interaction networks, which revealed four key ingredients and 14 significant targets.
- - Enrichment analyses highlighted numerous biological processes and pathways associated with SNFYT, suggesting that its therapeutic effects on ischemic stroke likely stem from its anti-inflammatory properties targeting specific signaling pathways.
Background: Malignant peripheral nerve sheath tumor (MPNST) is a type of spindle cell sarcoma originating from the peripheral nerve, which usually results in the corresponding nerve sign on magnetic resonance imaging (MRI). Patients with MPNST may also have neurofibromatosis type 1.
Case Summary: A 78-year-old male was admitted to the hospital due to a tumor in his left knee.
Article Synopsis
- Fish generally use protein for energy instead of carbohydrates, which affects their ability to store dietary protein and is linked to energy balance and protein turnover.
- This study investigates how inhibited mitochondrial fatty acid β-oxidation (FAO) influences energy homeostasis and protein deposition in fish, using carnitine-depleted Nile tilapia and CRISPR-modified zebrafish as models.
- Results showed significant reductions in mitochondrial FAO in the experimental groups compared to controls, but also increased glucose oxidation and muscle protein deposition, indicating a shift in metabolic strategies when FAO is impaired.
Article Synopsis
- Researchers studied heavy metal pollution from traffic in Lanzhou City by measuring metal elements in soil using an atomic absorption spectrophotometer.
- Results indicated significant increases in heavy metals like chromium, zinc, copper, and nickel, with chromium, copper, and lead marked as moderate pollutants, while the potential ecological risk ranking was Cu>Pb>Cr>Ni>Zn>Mn.
- Certain greening plants, like Sophora japonica and Rosa chinesis, showed different abilities to accumulate these metals, with higher chlorophyll and calcium levels in some species suggesting they might thrive in polluted areas.
Article Synopsis
- Interleukin-15 (IL-15) is a cytokine similar to IL-2 and plays a crucial role in both innate and adaptive immune responses, impacting various cardiovascular diseases (CVDs) like myocardial infarction and atherosclerosis.
- IL-15 is associated with pro-inflammatory effects, decreasing cardiomyocyte death and enhancing heart function, but it also promotes atherogenesis, indicating a complex role in CVDs.
- Future research on the IL-15/IL-15R system could lead to innovative treatments for cardiovascular diseases, making IL-15 a promising therapeutic target.
Article Synopsis
- l-Carnitine is crucial for fat metabolism in both humans and fish, while d-Carnitine is its optical isomer but has different effects when consumed.
- A study using a low-carnitine model in Nile tilapia found that feeding l-carnitine decreased liver fat and improved energy metabolism, while d-carnitine led to increased liver fat and inflammation.
- The results suggest that l-carnitine benefits fish health and metabolism, whereas d-carnitine acts like a harmful substance and may cause lipotoxicity, making it unsuitable for farmed animals.
Article Synopsis
- CEGI injection, made from rabbit muscle extract and cattle brain gangliosides, is used as a neuroprotectant for nerve injuries, but more clinical evidence is needed to support its efficacy.
- A study involving 319 patients with acute cerebral infarction in China scrutinized CEGI's effects in a randomized placebo-controlled trial over 14 days.
- Results indicated that patients receiving CEGI had better outcomes and reduced disabilities compared to the placebo group, with particularly significant improvements in those with moderate stroke.
Article Synopsis
- - Duchenne muscular dystrophy (DMD) is a serious neuromuscular disorder caused by mutations in the dystrophin gene, leading to progressive muscle weakness and high risks of cardiac issues and heart failure, which are now major causes of death in these patients.
- - A 15-year-old boy with a long history of DMD experienced recurrent heart symptoms, including palpitations and orthopnea, despite medication attempts; a diagnosis of atrial tachycardia was confirmed, and adjustments to his medication regimen were required to control his heart rate.
- - The case highlights the importance of monitoring blood pressure in DMD patients with heart failure when using medications like sacubitril/valsartan, as they can
Article Synopsis
- Impaired mitochondrial fatty acid β-oxidation is linked to various metabolic syndromes, yet its effects on fish metabolism remain unexplored.
- This study created a low-carnitine zebrafish model using mildronate, showing significant changes in nutrient metabolism, including increased fatty acid accumulation and altered glucose and protein processing.
- The findings highlight the importance of mitochondrial fatty acid β-oxidation in fish nutrient metabolism and suggest that this zebrafish model can aid further research in metabolic dysfunction.