Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus SCNU-F0041.

A new indigotin alkaloid, named talarindigotin A (), along with the analogue 5H, 6H-quinindolin-11-one () were isolated from the mangrove endophytic fungus SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC values ranging from 2.

Exploring size-dependent optical property alterations in fine-tuning intermetallic PdCd nanocube sizes.

Tuning the size of intermetallic nanocrystals is challenging due to the conflicting effects of surface free energy and surface diffusion on the disorder-to-order phase transition during wet-chemistry growth. Herein, we synthesized intermetallic PdCd nanocubes with tunable sizes ranging from 8 to 15 nm by adjusting the Cd precursor concentrations using a wet-chemistry approach. This process shares a mechanism of size tuning similar to quantum dot synthesis, involving the regulation of monomer concentration determined by the precursor concentrations.

Multimodal abnormalities of brain structures in adolescents and young adults with major depressive disorder: An activation likelihood estimation meta-analysis.

Background: Major depressive disorder (MDD) in adolescents and young adults contributes significantly to global morbidity, with inconsistent findings on brain structural changes from structural magnetic resonance imaging studies. Activation likelihood estimation (ALE) offers a method to synthesize these diverse findings and identify consistent brain anomalies.

Aim: To identify consistent brain structural changes in adolescents and young adults with MDD using ALE meta-analysis.

Sum and difference frequency generation in a valley-photonic-crystal-like topological system.

Nonlinear sum frequency generation (SFG) and difference frequency generation (DFG) are fundamental methods to obtain new light sources for various applications. However, most of the on-chip SFG and DFG are based on conventional resonators, lacking robustness against fabrication defects. Here, we demonstrate topologically protected SFG and DFG in a second-order topological photonic system.

Vulnerable brain regions in adolescent major depressive disorder: A resting-state functional magnetic resonance imaging activation likelihood estimation meta-analysis.

Background: Adolescent major depressive disorder (MDD) is a significant mental health concern that often leads to recurrent depression in adulthood. Resting-state functional magnetic resonance imaging (rs-fMRI) offers unique insights into the neural mechanisms underlying this condition. However, despite previous research, the specific vulnerable brain regions affected in adolescent MDD patients have not been fully elucidated.

Effects of opioid-free anaesthesia compared with balanced general anaesthesia on nausea and vomiting after video-assisted thoracoscopic surgery: a single-centre randomised controlled trial.

Objectives: Opioid-free anaesthesia (OFA) has emerged as a promising approach for mitigating the adverse effects associated with opioids. The objective of this study was to evaluate the impact of OFA on postoperative nausea and vomiting (PONV) following video-assisted thoracic surgery.

Design: Single-centre randomised controlled trial.

Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study.

Objectives: Type 2 diabetic kidney disease (DKD), a chronic microvascular complication of diabetes, may exhibit a complex interrelation with coagulation function. This study is aimed at elucidating the association between coagulation function and DKD.

Methods: This was a real-world observational study conducted in Beijing, involving 2,703 participants.

Association between serum complements and kidney function in patients with diabetic kidney disease.

Objective: We aimed to explore the association between serum complements and kidney function of diabetic kidney disease (DKD) in Chinese patients.

Methods: This is a retrospective study involving 2,441 participants. DKD was diagnosed according to the Kidney Disease: Improving Global Outcomes (KDIGO) categories.

Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease.

The study aimed to examine the association of three anemia-related biomarkers with the adequacy of peritoneal dialysis (PD) in patients with chronic kidney disease (CKD). This study included 127 PD patients. The total Kt/V urea (Kt/V) was calculated according to the Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines.

A new chromone from endophytic fungus sp. ZJ-68.

One chromone (), together with four known alkaloids, were isolated from the mangrove endophytic fungus sp. ZJ-68. Their structures were elucidated by a combination of HRESIMS and NMR spectroscopic analyses.

Association between thyroid hormones and diabetic kidney disease in Chinese adults.

Objective: We aimed to explore the association between thyroid hormones and different stages of diabetic kidney disease (DKD) in Chinese adults.

Methods: This is a retrospective study involving 2,832 participants. DKD was diagnosed and classified according to the Kidney Disease: Improving Global Outcomes (KDIGO) categories.

A new alkaloid from endophytic fungus sp. TM-Y1-1.

A new alkaloid (), together with three known compounds, were isolated from the endophytic fungus TM-Y1-1. Their structures were elucidated by extensive spectroscopic methods. The absolute configuration of compound was determined for the first time by ECD calculation and DP4+ analysis.

Increasing screening for atrial fibrillation in general practice: the Atrial Fibrillation Self-Screening, Management And guideline-Recommended Therapy (AF Self-SMART) study.

Objective: To assess whether atrial fibrillation (AF) self-screening stations in general practice waiting rooms improve AF screening, diagnosis, and stroke risk management.

Design, Setting: Intervention study (planned duration: twelve weeks) in six New South Wales general practices (two in rural locations, four in greater metropolitan Sydney), undertaken during 28 August 2020 - 5 August 2021.

Participants: People aged 65 years or more who had not previously been diagnosed with AF, and had appointments for face-to-face GP consultations.

De novo transcriptome revealed genes involved in anthocyanin biosynthesis, transport, and regulation in a mutant of Acer pseudosieboldianum.

Background: Acer pseudosieboldianum is a kind of excellent color-leafed plants, and well known for its red leaves in autumn. At the same time, A. pseudosieboldianum is one of the native tree species in the northeast of China, and it plays an important role in improving the lack of color-leafed plants in the north.

Association Between Dietary Salt and Plasma Glucose, Insulin and Hemoglobin A Levels Among Type 2 Diabetes Patients in Eastern China.

Purpose: Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycemic response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A (HbA ) levels in T2D patients.

36-Month Evaluation of a Weight Management Programme in Chinese Overweight and Obese Adults.

Few comprehensive lifestyle intervention programmes have been investigated on overweight and obese adults in China. This study was to evaluate the effect of a 36-month weight management programme on weight loss and its maintenance among overweight and obese patients in Ningbo, China. Adults with BMI ≥24/ enrolled in this programme, including nutritional, physical activity, psychological and endocrinological counselling sessions, from July 2015 to January 2020.

Surgical treatment of abnormal systemic artery to the left lower lobe: A case report.

Background: Abnormal systemic artery to the left lower lobe is a rare congenital abnormality characterized by anomalous communication between the systemic and pulmonary circulation. Owing to its rarity, there is limited clinical experience with respect to the diagnosis and treatment of this disease.

Case Summary: We report a 60-year-old man who presented with a history of hemoptysis for 20 d.

A Network Pharmacology Approach to Explore the Mechanism of HuangZhi YiShen Capsule for Treatment of Diabetic Kidney Disease.

Background And Objective: HuangZhi YiShen Capsule (HZYS) is a Chinese patent herbal drug that protects kidney function in diabetic kidney disease (DKD) patients. However, the pharmacologic mechanisms of HZYS remain unclear. This study would use network pharmacology to explore the pharmacologic mechanisms of HZYS.

De novo transcriptome sequencing and anthocyanin metabolite analysis reveals leaf color of Acer pseudosieboldianum in autumn.

Background: Leaf color is an important ornamental trait of colored-leaf plants. The change of leaf color is closely related to the synthesis and accumulation of anthocyanins in leaves. Acer pseudosieboldianum is a colored-leaf tree native to Northeastern China, however, there was less knowledge in Acer about anthocyanins biosynthesis and many steps of the pathway remain unknown to date.

Concentrations of Polybrominated Diphenyl Ethers in Maternal Blood, Placental Size, and Risk for Fetal Growth Restriction: A Nested Case-control Study.

Objective: To explore the effects of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on placental size and birth outcomes.

Methods: Based on the perspective Wenzhou Birth Cohort, this nested case-control study included 101 fetal growth restriction (FGR) and 101 healthy newborns. Maternal serum samples were collected during the third trimester and measured for PBDEs by gas chromatography tandem mass spectrometry.

[Dynamics of three-dimensional ecological footprint of Zhejiang coastal zone and its influencing factors based on GTWR model].

Clarifying the consumption of local natural capital stock and natural capital flow and its influencing factors can help alleviate the tension between the socio-economic development of the coastal zone, natural resources, and the ecological environment, and promote regional coordinated and sustainable development. Based on the two-dimensional and three-dimensional ecological footprint evaluation models, we analyzed the spatial and temporal variations of ecological footprint in the coastal zone of Zhejiang Province from 2006 to 2016, and explored the regional natural capital stock and capital flow occupancy based on footprint depth and footprint width. We analyzed the spatial and temporal heterogeneity of its influencing factors using a geographically and temporally weighted regression model.

Predictive factors for pleural drainage volume after uniportal video-assisted thoracic surgery lobectomy for non-small cell lung cancer: a single-institution retrospective study.

Objective: To identify the predictive factors associated with pleural drainage volume (PDV) after uniportal video-assisted thoracic surgery (VATS) lobectomy for non-small cell lung cancer (NSCLC).

Methods: A total of 440 consecutive NSCLC patients who underwent uniportal VATS lobectomy were enrolled in this study between November 2016 and July 2019. Thirty-four parameters, including patients' clinicopathological characteristics and other potential predictors were collected.