Higher odds of periodontitis in systemic lupus erythematosus compared to controls and rheumatoid arthritis: a systematic review, meta-analysis and network meta-analysis.

Introduction: Periodontitis as a comorbidity in systemic lupus erythematosus (SLE) is still not well recognized in the dental and rheumatology communities. A meta-analysis and network meta-analysis were thus performed to compare the (i) prevalence of periodontitis in SLE patients compared to those with rheumatoid arthritis (RA) and (ii) odds of developing periodontitis in controls, RA, and SLE.

Methods: Pooled prevalence of and odds ratio (OR) for periodontitis were compared using meta-analysis and network meta-analysis (NMA).

Conventional versus comprehensive dental prophylaxis: comparing the clinical outcomes between rubber cup and air polishing and the importance of plaque disclosure.

Objective: This study aimed to compare the clinical outcomes in dental prophylaxis between rubber cup polishing and an air polishing system using erythritol powder, with or without prior dental plaque disclosure. Method and materials: In this single-blind, randomized, controlled, split-mouth clinical trial, healthy participants with full-mouth plaque score ≥ 60% were recruited. Quadrants in each participant were randomly assigned to four treatment groups: air polishing with prior plaque disclosure; air polishing without plaque disclosure; rubber cup polishing with prior plaque disclosure; or rubber cup polishing without plaque disclosure.

Clinical and histological sequelae of surgical complications in horizontal guided bone regeneration: a systematic review and proposal for management.

It is not uncommon to encounter post-surgical complications after horizontal guided bone regeneration (GBR). The primary aim of this review was to evaluate the incidence and types of complications that occur after horizontal GBR and propose management strategies to deal with these clinical situations. A secondary aim was to conduct a histomorphometric review of the wound healing process at sites that experienced post-surgical complications after GBR.

Breaking the wave of peri-implantitis.

Peri-implant diseases are prevalent with a weighted mean prevalence rate of 43% across Europe and 22% across South and North America. Although the main etiologic agent is bacterial biofilm, a myriad of factors influence the initiation and progression of the disease. Unfortunately, the treatment of peri-implant diseases is at best favorable in the short term with a high rate of persistent inflammation and recurrence.

Biotransformation of Piceatannol, a Dietary Resveratrol Derivative: Promises to Human Health.

Scope: To evaluate the health-promoting potentials of piceatannol (PIC), a dietary resveratrol derivative, its biotransformation is examined.

Methods And Results: The biotransformation is tested in human/rat hepatic microsomes and cytosols; its pharmacokinetic profiles are assessed in rats. Although limited phase I metabolism exists in microsomes, PIC is rapidly converted to two pharmacologically active metabolites, namely rhapontigenin (RHA) and isorhapontigenin (ISO) in cytosols.

Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration.

Mesenchymal stem cells (MSCs) are potential therapeutics for the treatment of periodontal defects. It is increasingly accepted that MSCs mediate tissue repair through secretion of trophic factors, particularly exosomes. Here, we investigated the therapeutic effects of human MSC exosome-loaded collagen sponge for regeneration of surgically created periodontal intrabony defects in an immunocompetent rat model.

Effect of Deproteinized Bovine Bone Mineral at Implant Dehiscence Defects Grafted by the Sandwich Bone Augmentation Technique.

The aim of this study was to compare the amount of radiographic horizontal buccal bone thickness (BBT) at implant dehiscence defects grafted with the sandwich bone augmentation (SBA) and modified sandwich bone augmentation (MSBA) techniques. Compared to the SBA technique, the MSBA approach involved an additional outer layer of deproteinized bovine bone mineral (DBBM) to maintain the space for bone regeneration for longer periods. A total of 19 patients, each with a buccal implant dehiscence defect, were recruited.

Role of salt inducible kinase 1 in high glucose-induced lipid accumulation in HepG2 cells and metformin intervention.

Aims: To investigate the roles of salt inducible kinase (SIK1) in high glucose-induced triglyceride accumulation in human hepatoma HepG2 cells as well as in the molecular mechanism by which metformin, a drug to treat diabetes, suppresses high glucose-induced lipogenesis.

Main Methods: A cell model for high glucose-induced hepatic steatosis was prepared by exposing HepG2 cells to high glucose (25mmol) in the absence or presence of metformin (0.5mmol).

Graft-Free Maxillary Sinus Floor Elevation: A Systematic Review and Meta-Analysis.

Background: This systematic review and meta-analysis aims to investigate survival rates of dental implants placed simultaneously with graft-free maxillary sinus floor elevation (GFSFE). Factors influencing amount of vertical bone gain (VBG), protruded implant length (PIL) in sinus at follow-up (PILf), and peri-implant marginal bone loss (MBL) are also evaluated.

Methods: Electronic and manual searches for human clinical studies on simultaneous implant placement and GFSFE using the lateral window or transcrestal approach, published in the English language from January 1976 to March 2016, were conducted.

Can Periimplantitis Be Treated?

Over the past few decades, dental implants have been found to have high predictability and survival rates because of improvements in knowledge, clinical expertise, and implant designs. As such, dental implants are frequently integrated in the clinical management of fully or partially edentulous patients. It is prudent to realize that despite the high early survival rates, dental implants do have their fair share of long-term esthetic, biological, and mechanical complications.

Surgical Site Assessment for Soft Tissue Management in Ridge Augmentation Procedures.

The success of bone augmentation is usually dependent on primary wound closure. This review provides a literature-based system to assess the predictability of achieving primary wound closure. Seven pertinent factors that determine the risk for wound exposure were identified: (1) the width of keratinized mucosa, (2) flap thickness, (3) flap tension, (4) vestibular depth, (5) type and (6) size of the bony defect, and (7) materials used.

The Effect of Vertical Implant Position in Relation to Adjacent Teeth on Marginal Bone Loss in Posterior Arches: A Retrospective Study.

Purpose: The aim of this retrospective study was to investigate the possible association between peri-implant marginal bone loss and the apicocoronal (vertical) positioning of dental implants placed adjacent to a tooth.

Materials And Methods: Dental records at the University of Michigan, School of Dentistry, were screened. To be included in the study, the patient had to have at least one implant in the premolar or molar region, unilaterally or bilaterally, in either arch, with an immediately mesial adjacent tooth.

Implant survival rate and marginal bone loss of 6-mm short implants: a 2-year clinical report.

Purpose: This study aimed to evaluate (1) the association between implant diameter and marginal bone loss (MBL) of short (6 mm) implants and (2) the survival rates of short implants.

Materials And Methods: Thirty-three 6-mm implants were placed in the mandibles of 16 qualified patients. The selected sites had > 5 mm ridge width and < 9 mm bone height.

A randomized clinical trial evaluating the efficacy of the sandwich bone augmentation technique in increasing buccal bone thickness during implant placement. II. Tomographic, histologic, immunohistochemical, and RNA analyses.

Objectives: This study aimed to evaluate the biologic and structural phenotypes of the bone regenerated via the sandwich bone augmentation (SBA) technique, on buccal implant dehiscence defects.

Material And Methods: Twenty-six patients with one buccal implant dehiscence defect each were randomly assigned to two groups. Both groups received a standardized amount of mineralized cancellous and cortical allogenic bone graft.

Polarization manipulation based on electromagnetically induced transparency-like (EIT-like) effect.

We proposed, designed and fabricated a high transparency of metasurface-based polarization controller at microwave frequencies, which consists of orthogonal two pairs of cut wires. The high transmission and the strong dispersion properties governed by electromagnetically induced transparency-like (EIT-like) effects for both incident polarizations make our device efficiently manipulating the polarization of EM waves. In particular, the proposed polarization device is ultrathin (~0.

Impact of implantoplasty on strength of the implant-abutment complex.

Purpose: Implantoplasty, a procedure that is done to smooth contaminated implant surfaces, has been used in the treatment of peri-implantitis. It reduces the implant diameter, which might compromise the implant's strength. This in vitro study was designed to evaluate the effect of implantoplasty on implant strength.

Using Cone Beam Computed Tomography Angle for Predicting the Outcome of Horizontal Bone Augmentation.

Background: The aim of this study was to assess the influence of ridge morphology on the amount of horizontal bone augmentation achieved with the sandwich bone augmentation (SBA) technique in the reconstruction of buccal dehiscence defects on dental implants.

Methods: Cone beam computed tomography (CBCT) was used to assess bone width changes in 26 patients who participated in a randomized controlled trial conducted in 2008 to 2011. The amount of horizontal bone gain was evaluated at four different levels (3, 6, 9, and 12 mm apical to the alveolar crest) and three different time points (T1: baseline, T2: at time of graft placement, and T3: 6 months later).

Ridge width gain with screw spreaders: a cadaver study.

Background: The aim of this cadaver study was to evaluate the amount of ridge expansion with screw spreaders.

Methods: Eleven edentulous maxillae providing 20 eligible sites were used. Ridges with initial width of 3 to 6 mm were expanded using a set of 6 screw spreaders, and implants (ø3.

A systematic review on marginal bone loss around short dental implants (<10 mm) for implant-supported fixed prostheses.

Purpose: This systematic review aimed to evaluate the effect of implant length on peri-implant marginal bone loss (MBL) and its associated influencing factors.

Material And Methods: An electronic search of the PubMed and MEDLINE databases for relevant studies published in English from November 2006 to July 2012 was performed by one examiner (AM). Selected studies were randomized clinical trials, human experimental clinical trials or prospective studies (e.

Alterations in bone quality after socket preservation with grafting materials: a systematic review.

Purpose: While the ability of various grafting materials to preserve extraction socket morphology has been adequately reviewed, the quality of the grafted bone in the socket is not as well understood. This systematic review aimed to compare the proportion of vital bone and connective tissue between grafted and naturally healed sockets.

Materials And Methods: An electronic search of five databases (from 1965 to November 2011) and a hand search of peer-reviewed journals for relevant articles were performed.

A randomized clinical trial evaluating the efficacy of the sandwich bone augmentation technique in increasing buccal bone thickness during implant placement surgery: I. Clinical and radiographic parameters.

Objectives: Sandwich bone augmentation (SBA) has been proposed to augment the width of edentulous ridges for implant placement. This study aimed to investigate the effect of a membrane on SBA for the regeneration of buccal implant dehiscence defects.

Material And Methods: Twenty-six healthy patients, each with a single defect, were randomly assigned into two groups.

Reliability of volumetric imaging software for cone-beam computed tomogram scans in the anterior maxilla.

Purpose: This study aimed to compare buccal bone thickness in the maxillary anterior region provided by cone-beam computed tomography scans of cadaveric specimens using 2 different volumetric imaging software.

Methods: Cone-beam computed tomography scans of the maxilla of 15 cadaver heads were obtained from a database at the School of Dentistry, University of Michigan. Buccal bone thickness of the right and left maxillary canines and lateral and central incisors was measured at 2.

Do implant length and width matter for short dental implants (<10 mm)? A meta-analysis of prospective studies.

Background: This meta-analysis of prospective clinical trials was conducted to determine the effects of dental implant length and width on implant survival rate of short (<10 mm) implants.

Methods: An electronic search of the PubMed database for relevant studies published in English from November 1998 to March 2012 was performed. Selected studies were randomized clinical trials, human clinical trials, or prospective trials with a clear aim of investigating the success or survival rate of short (<10 mm) implants.

Controlling the proliferation and differentiation stages to initiate periodontal regeneration.

The success of periodontal regeneration depends on the coordination of early cell proliferation and late cell differentiation. The aim of this study was to investigate whether the proliferation or differentiation stage predominantly promotes the initiation of periodontal regeneration. Critical-sized periodontal defects were surgically created on rat maxillae and filled with poly-(D,L-lactide-co-glycolide)-poly-d,l-lactide hybrid microspheres encapsulating platelet-derived growth factor (PDGF, a promoter of mitogenesis), simvastatin (a promoter of osteogenic differentiation), or bovine serum albumin (a control).

The success rate of narrow body implants used for supporting immediate provisional restorations: a pilot feasibility study.

Background: Implants were first designed to be used in the reconstruction of edentulous mandibles. However, with the technological advancement, enormous changes were made to improve the implant design and surface characteristics leading to the wide use of implants in the replacement of missing teeth. During the transition from an edentulous span to a fixed prosthesis, narrow body implants (NBIs) have been proposed to enhance patient comfort and function.