Publications by authors named "Jia Gwee"
DNA methylation is an important epigenetic mechanism essential for transposon silencing and genome integrity. Across evolution, the substrates of DNA methylation have diversified between kingdoms. In plants, chromomethylase3 (CMT3) and CMT2 mediate CHG and CHH methylation, respectively.
View Article and Find Full Text PDFDNA methylation is an important epigenetic mechanism essential for transposon silencing and genome integrity. Across evolution, the substrates of DNA methylation have diversified between kingdoms to account for genome complexity. In plants, Chromomethylase3 (CMT3) and CMT2 are the major methyltransferases mediating CHG and CHH methylation, respectively.
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- Researchers found a gene called TBK1 that helps cancer cells avoid being attacked by the immune system.
- By blocking TBK1, they made cancer treatments, like PD-1 blockade, more effective.
- Experiments with real patient tumors showed that targeting TBK1 can help kill cancer cells better when combined with certain immune signals.