Publications by authors named "Jia Chuan Yan"
Article Synopsis
- This study developed a self-rating anxiety inventory specifically for maintenance haemodialysis (MHD) patients, called AI-MHD, consisting of 12 items to effectively screen for anxiety disorders.
- After preliminary validation and comparisons with established scales like GAD-7 and HADS-A, the AI-MHD demonstrated strong reliability with a Cronbach's alpha of 0.918 and significantly distinguished between patients with and without anxiety disorders.
- The AI-MHD showed high detection rates (93%) and specificity (90%), outperforming the existing screening methods, although the study acknowledged limitations like sample size and regional focus.
Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). Clearance of Aβ is a promising therapeutic strategy for AD. We have previously demonstrated that peripheral organs play important roles in the clearance of brain-derived Aβ.
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- Amyloid precursor protein (APP) is processed to produce amyloid-β peptide (Aβ), which is linked to Alzheimer's disease (AD), while α-secretase (like ADAM10) reduces Aβ production and provides neuroprotection.
- A case-control study involving 200 sporadic Alzheimer's patients and 243 controls in a Chinese Han population aimed to assess the impact of SNPs in APP and ADAM10 genes on AD risk.
- The study found a potential association of one SNP (rs463946) with sporadic AD risk, but these results did not stand after correcting for multiple comparisons, and no significant links were established for the ADAM10 SNPs or haplotypes.
Carotid stenosis is known to be an independent risk factor in the transformation process of mild cognitive impairment (MCI) to dementia and is treated by carotid artery stenting (CAS); however, the effects of CAS on cognitive function are unclear. In this study, 240 patients were prospectively assigned to a CAS or control group according to patient preference and underwent detailed neuropsychological examinations (NPEs) before and 6 months after treatment. Cerebral perfusion was assessed with computed tomography perfusion (CTP).
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- A study involving 415 Alzheimer's disease (AD) patients aged 65 and older explored how vascular risk factors influence the progression of the disease over five years.
- Results showed that AD patients with vascular risks, such as hypertension and diabetes, experienced a faster decline in cognitive and functional abilities compared to those without these risks.
- The findings indicate that managing vascular risk could potentially slow down the progression of Alzheimer's disease, suggesting a link between vascular health and the severity of AD.