The effects and predictive values of novel anthropometric parameters on uric acid levels and hyperuricemia in adults.

Novel anthropometric indices are more closely related to metabolic abnormalities than traditional anthropometric indices. Fewer studies have been conducted based on the relationship between novel anthropometric indicators and hyperuricemia. This study was to analyze the serum uric acid (SUA) levels of adults and the relationship between hyperuricemia and these new indicators in Su-Wuxi-Chang area of China, in order to provide a theoretical basis for the management of SUA levels in patients with hyperuricemia.

CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies.

Purpose: CD38 is a glycoprotein highly specific to multiple myeloma (MM). Therapeutics using antibodies targeting CD38 have shown promising efficacy. However, the efficient stratification of patients who may benefit from daratumumab (Dara) therapy and timely monitoring of therapeutic responses remain significant clinical challenges.

Gene Family Identification in Chinese White Pear () and the Functional Analysis of in Fe Deficiency Responses in Tomato.

Iron (Fe) deficiency poses a major threat to pear ( spp.) fruit yield and quality. The () plays a vital part in plant stress responses.

Functional Analysis of CPSF30 in Using RNA Interference Reveals Its Essential Role in Development and Survival.

The brown planthopper () is a major pest threatening global rice production, significantly reducing yields annually. As increasingly develops resistance to conventional control methods, such as chemical pesticides, there is an urgent need for innovative and sustainable pest management strategies. Cleavage and Polyadenylation Specificity Factor 30 (CPSF30) is a key protein involved in mRNA 3' end processing, yet its function in remains poorly understood.

Nuclear imaging of PD-L1 expression promotes the synergistic antitumor efficacy of targeted radionuclide therapy and immune checkpoint blockade.

Purpose: In order to maximize synergistic effect of targeted radionuclide therapy (TRT) and immune checkpoint blockade (ICB) as well as reduce the toxicity, we pioneered a strategy guided by PD-L1-targeted nuclear medicine imaging for the combination of TRT and ICB towards precision cancer therapy.

Methods: As a novel targeted radiotherapeutic agent, Lu-AB-3PRGD targeting integrin αβ was developed to achieve sustained antitumor effect by introducing an albumin binder (AB) into the structure of 3PRGD. The Lu-AB-3PRGD TRT as well as different types of combination therapies of Lu-AB-3PRGD TRT and anti-PD-L1 ICB were performed in animal models.

Nondestructive Detection of Corky Disease in Symptomless 'Akizuki' Pears via Raman Spectroscopy.

'Akizuki' pear ( Nakai) corky disease is a physiological disease that strongly affects the fruit quality of 'Akizuki' pear and its economic value. In this study, Raman spectroscopy was employed to develop an early diagnosis model by integrating support vector machine (SVM), random forest (RF), gradient boosting decision tree (GBDT), extreme gradient boosting (XGBoost), and convolutional neural network (CNN) modeling techniques. The effects of various pretreatment methods and combinations of methods on modeling results were studied.

Genome-Wide Analysis of Aquaporins Gene Family in and Its Expression Patterns in Response to Drought, Salt Stress, and Phytohormones.

Aquaporins (AQPs) play an essential role in membrane water transport during plant responses to water stresses centered on conventional upstream signals. Phytohormones (PHs) regulate plant growth and yield, working with transcription factors to help plants withstand environmental challenges and regulate physiological and chemical processes. The AQP gene family is important, so researchers have studied its function and regulatory system in numerous species.

Transcriptome Analysis and Identification of Genes Associated with Cotton Seed Size.

Cotton seeds, as the main by-product of cotton, are not only an important raw material for edible oil and feed but also a source of biofuel. The quality of cotton seeds directly affects cotton planting and is closely related to the yield and fiber quality. However, the molecular mechanism governing cotton seed size remains largely unexplored.

Assessment of the Restoration Potential of Forest Vegetation Coverage in the Alxa Desert Region of China.

To scientifically evaluate the sustainability of tree planting and afforestation in the Alxa Desert region, this study, grounded in the principles of water balance within the natural water cycle, employed multi-source remote sensing products and ground-based measurements to construct a quantitative response relationship model. This model links evapotranspiration (ET) with meteorological variables and the Enhanced Vegetation Index (EVI). Furthermore, the study estimated the recovery thresholds and potential of forest and grassland vegetation coverage in the Alxa Desert region under various precipitation scenarios.

Claudin18.2-Targeted SPECT/CT Imaging for Gastric Cancer: Preclinical Evaluation and Clinical Translation of the Tc-Labeled Nanobody (PHG102) Radiotracer.

Claudin18.2 (CLDN18.2) has emerged as a significant target in the treatment of advanced gastric cancer.

Deciphering the dynamic expression network of fiber elongation and the functional role of the GhTUB5 gene for fiber length in cotton based on an introgression population of upland cotton.

Introduction: Interspecific introgression between Gossypium hirsutum and G. barbadense allows breeding cotton with outstanding fiber length (FL). However, the dynamic gene regulatory network of FL-related genes has not been characterized, and the functional mechanism through which the hub gene GhTUB5 mediates fiber elongation has yet to be determined.

Study on full-scale pores characterization and heterogeneity of coal based on low-temperature nitrogen adsorption and low-field nuclear magnetic resonance experiments.

The characteristics and heterogeneity of coal pores are crucial for understanding the production mechanism of coalbed methane (CBM). In this study, coal samples with varying degrees of metamorphism (0.58%  ≤ R, ≤ 3.

Determination of anthracnose (Colletotrichum fructicola) resistance mechanism using transcriptome analysis of resistant and susceptible pear (Pyrus pyrifolia).

Background: Anthracnose, mainly caused by Colletotrichum fructicola, leads to severe losses in pear production. However, there is limited information available regarding the molecular response to anthracnose in pears.

Results: In this study, the anthracnose-resistant variety 'Seli' and susceptible pear cultivar 'Cuiguan' were subjected to transcriptome analysis following C.

Synthesis, preclinical evaluation and pilot clinical translation of [Ga]Ga-PMD22, a novel nanobody PET probe targeting CLDN18.2 of gastrointestinal cancer.

Purpose: Claudin18.2 (CLDN18.2) is a novel target for diagnosis and therapy of gastrointestinal cancer.

Changes of soil carbon along precipitation gradients in three typical vegetation types in the Alxa desert region, China.

The changes and influencing factors of soil inorganic carbon (SIC) and organic carbon (SOC) on precipitation gradients are crucial for predicting and evaluating carbon storage changes at the regional scale. However, people's understanding of the distribution characteristics of SOC and SIC reserves on regional precipitation gradients is insufficient, and the main environmental variables that affect SOC and SIC changes are also not well understood. Therefore, this study focuses on the Alxa region and selects five regions covered by three typical desert vegetation types, Zygophyllum xanthoxylon (ZX), Nitraria tangutorum (NT), and Reaumuria songarica (RS), along the climate transect where precipitation gradually increases.

The dominant influencing factors of desertification and ecological risk changes in Qinghai Area of Qilian Mountains National Park: Climate change or human activity?

Transitional features of desert environments partially determine the risks associated with ecosystems. Influenced by climate change and human activities, the variability and uncertainty of desertification levels and ecological risks in the Qinghai Area of Qilian Mountain National Park (QMNPQA) has become increasingly prominent. As a critical ecological barrier in northwest China, monitoring desertification dynamics and ecological risks is crucial for maintaining ecosystem stability.

Co-localization and analysis of miR477b with fiber length quantitative trait loci in cotton.

Cotton is an important cash crop for the textile industry. However, the understanding of natural genetic variation of fiber elongation in relation to miRNA is lacking. A miRNA gene (miR477b) was found to co-localize with a previously mapped fiber length (FL) quantitative trait locus (QTL).

Ga-NC-BCH Whole-Body PET Imaging Rapidly Targets Claudin18.2 in Lesions in Gastrointestinal Cancer Patients.

Ga-labeled nanobody (Ga-NC-BCH) is a single-domain antibody-based PET imaging agent. We conducted a first-in-humans study of Ga-NC-BCH for PET to determine its in vivo biodistribution, metabolism, radiation dosimetry, safety, and potential for quantifying claudin-18 isoform 2 (CLDN18.2) expression in gastrointestinal cancer patients.

TRIM59-mediated ferroptosis enhances neuroblastoma development and chemosensitivity through p53 ubiquitination and degradation.

Neuroblastoma, predominantly afflicting young individuals, is characterized as an embryonal tumor, with poor prognosis primarily attributed to chemoresistance. This study delved into the impact of tripartite motif (TRIM) 59, an E3 ligase, on neuroblastoma development and chemosensitivity through mediating ferroptosis and the involvement of the tumor suppressor p53. Clinical samples were assessed for TRIM59 and p53 levels to explore their correlation with neuroblastoma differentiation.

Genome-wide identification of GA2ox genes family and analysis of PbrGA2ox1-mediated enhanced chlorophyll accumulation by promoting chloroplast development in pear.

Background: Chlorophyll (Chl) is an agronomic trait associated with photosynthesis and yield. Gibberellin 2-oxidases (GA2oxs) have previously been shown to be involved in Chl accumulation. However, whether and how the PbrGA2ox proteins (PbrGA2oxs) mediate Chl accumulation in pear (Pyrus spp.

Noninvasive Evaluation of Tumoral PD-L1 Using a Novel Tc-Labeled Nanobody Tracer with Rapid Renal Clearance.

The expression level of PD-L1 in tumor tissue is considered one of the effective biomarkers to guide PD-1/PD-L1 therapy. Quantifying whole-body PD-L1 expression by SPECT imaging may help in selecting patients that potentially respond to PD-1/PD-L1 therapy. Nanobody is the smallest antibody fragment with antigen-binding ability that is well suited for radionuclide imaging.

Transcriptome Analysis Reveals Key Genes Involved in the Response of to Drought and High-Temperature Stress.

Drought and high-temperature stress are the main abiotic stresses that alone or simultaneously affect the yield and quality of pears worldwide. However, studies on the mechanisms of drought or high-temperature resistance in pears remain elusive. Therefore, the molecular responses of , the widely used rootstock in pear production, to drought and high temperatures require further study.

Effects of long-term afforestation on soil water and carbon in the Alxa Plateau.

Plantations in dry and semi-arid areas significantly affect the soil's ability to store carbon and maintain a stable water balance. It is yet unclear, though, how planted trees in these regions might impact the soil's carbon and water levels. As a forest ages, it is unknown how soil water and soil carbon interact with one another.

Genomic and co-expression network analyses reveal candidate genes for oil accumulation based on an introgression population in Upland cotton (Gossypium hirsutum).

Integrated QTL mapping and WGCNA condense the potential gene regulatory network involved in oil accumulation. A glycosyl hydrolases gene (GhHSD1) for oil biosynthesis was confirmed in Arabidopsis, which will provide useful knowledge to understand the functional mechanism of oil biosynthesis in cotton. Cotton is an economical source of edible oil for the food industry.