Roles of cryo/thermal strength for redispersibility of drug nanocrystals: a representative study with andrographolide.

Due to limited understanding about the effect of cryo/thermal strength from drying process on the redispersibility of drug nanocrystals, the impact of the different type and concentration of stabilizers and matrix formers on the redispersibility of nanocrystals were systematically investigated. Andro nanosuspensions were transformed into Andro nanocrystals (Andro-NC) via different drying process. The results demonstrated that the redispersibility of Andro-NC at the aggressive cryo-strength (meant higher freezing rate) was more excellent than those at conservative and moderate condition.

Microcrystalline cellulose-carboxymethyl cellulose sodium as an effective dispersant for drug nanocrystals: A case study.

This study is aimed at seeking an alternative dispersant for spray drying of drug nanosuspensions. The ideal dispersant is not only able to prevent the agglomeration of drug nanocrystals in the suspension state, but also it is able to preserve redispersibility of drug nanocrystals after drying. An active pharmaceutical ingredient (API) was used as a model drug.

The importance of solidification stress on the redispersibility of solid nanocrystals loaded with harmine.

Due to limited understanding about effect of solidification stress on the redispersibility of drug nanocrystals, the impact of the different type and concentration of stabilizers and cryoprotectants, as well as the solidification temperature on the redispersibility of nanocrystals were systematically investigated. Harmine nanosuspensions were transformed into harmine solid nanocrystals (HAR-SNC) via different stress of solidification process including freezing, lyophilization and spray-drying. The effect of different concentrations of stabilizers and cryoprotectants on redispersibility of HAR-SNC was also investigated, respectively.

Study on formability of solid nanosuspensions during solidification: II novel roles of freezing stress and cryoprotectant property.

The freezing stress and cryoprotectants were known to be the crucial factors for solidification formability of nanosuspensions during freeze-drying. However, there has been controversy as to whether an aggressive or conservative freezing stress (freezing temperature or freezing rate) prevents from irreversible aggregation of nanosuspensions. And the screening of cryoprotectants for solidification formability of nanosuspensions has largely relied on empirical approaches.