Publications by authors named "JiPing Liu"
Ethnopharmacological Relevance: Dioscorea bulbifera L. (DBL) was a traditional Chinese medicine commonly used to treat goitre and cancer. Nevertheless, its clinical application may lead to liver injury.
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- The Daqinjiao decoction (DQJT) has a long history of use in stroke treatment, but its mechanisms remained largely unknown before this study.
- The study aimed to explore how DQJT alleviates brain injury caused by cerebral ischemia/reperfusion by using methods like HPLC for component analysis and MCAO/R models for efficacy testing.
- Results indicated that DQJT effectively reduces brain damage and improves metabolic pathways, focusing on lipid metabolism and specific signaling pathways, ultimately revealing its role in inhibiting cell death processes through the modulation of several key pathways.
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- PM2.5 exposure can cause brain damage through systemic inflammation and oxidative stress, but the specific mechanisms are still not fully understood.
- Baicalin (BC) and geniposide glycosides (GD) may help protect the brain by reducing inflammation and oxidative damage.
- In a study using a mouse model, BC and GD were found to effectively reduce brain injury caused by PM2.5, potentially by modulating the 5-LOX/LTB4 pathway and alleviating inflammatory responses in the brain.
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- Ganoderma lucidum, known as "fairy grass," is a traditional Chinese tonic with various beneficial chemical components that help improve overall health and treat conditions like lung issues and fatigue.
- The primary bioactive ingredient, Ganoderma lucidum polysaccharides (GLPs), has demonstrated a range of medicinal properties, including enhancing immunity and inhibiting tumor growth.
- The article reviews recent research on GLPs, covering their extraction, benefits, and potential applications in medicine, food, and consumer products, aiming to support the use of Ganoderma lucidum in traditional medicine.
Research progress of sea buckthorn () in prevention and treatment of cardiovascular disease.
Front Cardiovasc Med
October 2024
Article Synopsis
- Sea buckthorn is rich in beneficial compounds and has shown promise in treating cardiovascular disorders through various mechanisms, including anti-inflammatory effects and lipid regulation.
- Clinical trials indicate that it can help manage lipid metabolism, blood pressure, and blood glucose levels.
- The paper reviews the safety, pharmacology, and potential therapeutic applications of sea buckthorn, highlighting its role as a new option for cardiovascular disease management.
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- Stylosanthes guianensis is a forage legume with strong aluminum (Al) toxicity resistance, characterized by the production of border-like cells (BLCs) around root tips, unlike Stylosanthes viscosa genotype TF0140.
- The S. guianensis genotype RY#2 showed greater Al retention in BLCs and enhanced root growth compared to TF0140, linked to changes in pectin metabolism and the expression of the gene SgPG1.
- Overexpressing SgPG1 led to increased BLC production and Al resistance, with the bHLH transcription factor SgbHLH19 identified as the regulator of SgPG1, indicating a key mechanism underlying aluminum resistance in S
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- Scientists wanted to find out how Puerarin (PU) can protect the liver from damage caused by a plant called Dioscorea bulbifera (DB).
- They conducted tests on mice to see how PU affected their liver health and checked for certain enzymes and proteins that show liver damage or inflammation.
- Results showed that PU helped the mice gain weight, improved their liver condition, and changed the levels of important proteins, making it clear that PU can help fight liver injury caused by DB.
Nitrogen inputs promote wetland carbon dioxide and nitrous oxide emissions in China: a meta-analysis.
Environ Sci Pollut Res Int
September 2024
Article Synopsis
- Nitrogen is the most limiting nutrient in wetlands, significantly affecting carbon and nitrogen cycling, particularly in response to nitrogen inputs in China.
- A study synthesized data from 27 studies, revealing that nitrogen addition increases carbon dioxide and nitrous oxide emissions but does not affect methane levels.
- High nitrogen inputs and specific conditions like soil acidity and temperature can enhance these emissions, highlighting the need to understand these dynamics for better greenhouse gas predictions and achieving carbon neutrality.
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- The periosteum houses skeletal stem/progenitor cells (P-SSCs) crucial for bone healing, but their exact identity and specific markers are not fully understood.
- Researchers discovered that the membrane protein Itm2a is enriched in P-SSCs, which show ability to self-renew and differentiate into various cell types necessary for bone repair.
- Itm2a+ P-SSCs, found primarily in the outer layer of the periosteum, play a significant role in fracture healing, and the study suggests that targeting Itm2a could lead to advancements in treatments for skeletal conditions.
The tonoplast-localized OsTIP2;1 is involved in aluminum detoxification in rice.
Plant Physiol Biochem
October 2024
Article Synopsis
- Aluminum stress in acidic soils significantly impacts crop growth, particularly affecting rice which shows some resilience to Al toxicity.
- OsTIP2;1, a tonoplast protein in rice, plays a crucial role in detoxifying Al internally, being rapidly activated by Al ions in roots.
- Rice mutants lacking OsTIP2;1 were more susceptible to Al due to lower Al levels in roots and increased translocation to shoots, highlighting its function in sequestering Al into vacuoles and enhancing Al resistance.
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- Ovarian cancer, particularly High-Grade Serous Ovarian Cancer, has high rates of recurrence and mortality, and existing organoid models lack important components like immune microenvironments and blood vessels.
- Researchers developed a novel organoid system from patient samples that retains the cancer's histological and molecular diversity while incorporating endothelial cells to mimic the immune environment and vascular structures.
- This new organoid model shows potential for personalized treatment options, effectively testing drug sensitivity and paving the way for innovative therapies, such as immunotherapy and angiogenesis inhibitors, for ovarian cancer patients.
Investigating the molecular mechanism of vitexin targeting CDK1 to inhibit colon cancer cell proliferation via GEO chip data mining, computer simulation, and biological activity verification.
Naunyn Schmiedebergs Arch Pharmacol
August 2024
Article Synopsis
- The study investigates how vitexin, a traditional Chinese medicine, affects colon cancer HCT-116 cells and the mechanisms behind its effects.
- The research found that vitexin significantly inhibits these cancer cells' growth, with an IC50 value indicating effective concentration, and causes cell cycle arrest in the G2/M phase.
- Molecular docking and simulations revealed that vitexin interacts strongly with the CDK1 protein, leading to decreased expression of CDK1/cyclin B, similar to other known cancer treatments.
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- Adaptive radiotherapy (ART) for small hepatocellular carcinoma (sHCC) faces challenges due to anatomical uncertainties and low-resolution CT scans, particularly in tumor identification and segmentation.
- The study explores using a gold nanoparticle (Au NP)-based CT contrast agent to enhance imaging for ART, showing that synthesized charged Au NPs have favorable properties like low cytotoxicity and minimal organ toxicity.
- CT images from an sHCC mouse model processed with advanced AI models (3D U-Net and 3D Trans U-Net) achieved high accuracy in tumor segmentation, indicating that charged Au NPs can significantly improve the effectiveness of ART by addressing technical issues.
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- Pebrine is a serious disease in the sericulture industry caused by microsporidia, and there is a lack of effective treatments or diagnostics available.
- The study focused on analyzing a specific gene (MetAP2) related to microsporidia from silkworms in Guangdong province, revealing important genetic and structural information about the protein.
- The findings suggest that MetAP2's evolutionary relationships are closely linked to silkworm species, providing valuable insights for developing better management strategies against pebrine infection.
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- A study was conducted to evaluate the effects of palmar ginseng on cognitive impairment caused by type 2 diabetes in a rat model, focusing on its neuroprotective properties and mechanisms.
- The research involved feeding rats a high-fat, high-sugar diet and administering palmar ginseng, followed by tests to assess changes in cognitive function, inflammation markers, and hippocampal tissue health.
- Results showed that palmar ginseng lowered blood glucose levels, improved learning and memory, reduced neuronal damage, and influenced certain protein pathways linked to inflammation and neuroprotection.
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- The flammability of epoxy resins is a crucial consideration, and improving their fire resistance during curing is essential.
- A new method is proposed that employs a three-source polymerization flame-retardant to enhance fire resistance and minimize smoke during the curing process.
- The study reports that adding 7 wt.% of a synthesized compound, PCS, not only improves the curing of epoxy resin but also significantly reduces heat release and smoke production, achieving impressive fire safety ratings.
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- Organoid research has rapidly advanced over the past decade, especially in 2023, with thousands of publications highlighting its growing significance in biomedicine.
- The review aims to fill the gap in comprehensive knowledge about organoids by exploring their history, technological advancements, and applications in fields like oncology and drug development.
- It discusses the future potential of organoids for personalized medicine and innovative drug discovery, making it a valuable resource for researchers, clinicians, and patients alike.
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- The alcohol extraction showed strong anti-cancer effects on NSCLC A549 cells by inhibiting free radicals and cell proliferation.
- Despite the presence of various components in the extraction, the specific active components and their targets are still not well-defined, warranting further research.
- The study successfully identified 17 active components and their interactions with 191 targets and critical signaling pathways linked to cancer, emphasizing the need for in-depth analysis of these mechanisms.
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- Cyclosporin A is widely used to prevent transplant rejection and treat autoimmune diseases but can lead to hypertension.
- Resveratrol was studied for its potential to reduce cyclosporin A-induced hypertension in rats by examining its effects on blood pressure and vasoconstriction mechanisms.
- The findings indicated that resveratrol alleviated hypertension caused by cyclosporin A by modulating specific signaling pathways and reducing vasoconstriction related to thromboxane A receptors.
Understanding Sorafenib-Induced Cardiovascular Toxicity: Mechanisms and Treatment Implications.
Drug Des Devel Ther
March 2024
Article Synopsis
- Tyrosine kinase inhibitors (TKIs), like sorafenib, are important for treating tumors by targeting the vascular endothelial growth factor receptor (VEGFR), but they can cause severe cardiovascular side effects.
- Sorafenib, effective against hepatocellular and renal cell carcinoma, inhibits tumor growth but is limited in its use due to issues like hypertension and heart dysfunction.
- The review focuses on the mechanisms behind sorafenib's cardiovascular effects, potential treatments to mitigate harm, and the need for further research on its impact on glycolysis, drug resistance, and overall treatment outcomes.
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- Shicao, a herb from Achillea alpina L., is traditionally used in Chinese medicine and is being studied for its ability to protect the liver from acute injury.
- A rat model was used to assess liver function and the protective effects of Shicao were evaluated through various biochemical and histological analyses, along with metabolomics to discover relevant metabolites.
- The findings indicated that Shicao significantly reduced liver damage and identified key metabolites and pathways involved in its hepatoprotective effects, suggesting its potential as a treatment for acute liver injury.
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- Ischaemic encephalopathy is a common cerebrovascular condition linked to chronic diseases like obesity, hypertension, and diabetes, with neurotrophic therapy being the primary treatment method, although it offers limited improvement in neurological function.
- Previous studies suggest that active ingredients from natural medicines can be beneficial in treating cerebral ischemia, leading researchers to explore heat-clearing herbs for their anti-ischaemic properties.
- The research involved analyzing 149 prescriptions from various databases, identifying commonly used heat-clearing herbs, and constructing a network that highlights the relationship between herbs, their active ingredients, and targets associated with ischaemic stroke.
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- Inland salt marsh wetlands play a crucial role in the ecology of semi-arid regions, but degradation has necessitated research on restoration effects over time.
- Our study examined the impact of two, four, and six years of wetland restoration on soil quality, focusing on total nitrogen (TN), total phosphorus (TP), and the nitrogen-to-phosphorus ratio (N:P).
- Results indicated that while TN levels improved significantly in restored wetlands compared to natural ones, TP levels fluctuated seasonally and decreased with soil depth, suggesting that restoration duration and depth both influence nutrient dynamics.
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- Aldose reductase 2 (ALR2) is a key target for treating diabetic peripheral neuropathy (DPN), but many existing inhibitors have side effects due to lack of selectivity.
- A new compound, 15c, shows strong inhibition against ALR2 with an impressive selectivity over another enzyme, ALR1, and has demonstrated good safety in cytotoxicity tests.
- In animal studies, 15c improved nerve function and reduced harmful substances linked to nerve damage, indicating its potential as a lead compound for developing new DPN treatments.
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- The study aimed to investigate the effects of Shuangshi Tonglin (SSTL) capsules on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and to understand how it works.
- Rats with CP/CPPS received intraprostatic injections and were given different doses of SSTL capsules for 28 days, leading to tests on pain levels and analysis of prostate tissue and blood samples.
- Results showed that SSTL treatment increased pain thresholds, reduced inflammation, and improved overall prostate health by decreasing inflammatory factors and activating protective protein pathways, suggesting SSTL is an effective treatment for prostatitis.