Ionic Liquid-Based Grapeseed Oil Emulsion for Enhanced Anti-Wrinkle Treatment.

Objectives: To address the poor efficacy and percutaneous penetration of grape seed oil, ionic liquids and nanotechnology were combined to prepare a grape seed oil emulsion.

Methods: A novel Menthol-CoQ10 ionic liquid and ionic liquid based grapeseed oil emulsion were prepared and confirmed.

Results: The average size of the grapeseed oil emulsion was 218 nm, and its zeta potential was -33.

Boosting Fast Charging of Lithium-Metal Batteries via Weak Interactions Between Non-Solvating Solvents and Anions in High-Safety Eutectic Electrolytes.

Proper design of the solvation structure is crucial for the development of lithium metal batteries (LMBs). In this paper, the use of 1,2-Dimethoxyethane (DME) as a non-solvating cosolvent in amide-based eutectic electrolytes is proposed to address challenges related to high viscosity, high polarization, and low conductivity, thus enhancing the compatibility with lithium metal anodes. Through physical characterization combined with simulation calculations the existence of a weak interaction between DME and anions is confirmed, which promotes the dissociation of lithium salts and increases the Li transference number and diffusion coefficient, thus improving the fast charging performance of eutectic electrolytes.

Ionic liquid combined with cationic liposome co-delivers microphthalmia-associated transcription factor small interfering RNA to regulate melanogenesis.

Suppressing allele-specific genes using small interfering RNAs (siRNAs) can effectively whiten skin by influencing cellular gene and protein expression. Topical delivery of siRNA is a promising alternative to injections for RNA interference. However, the barrier function of the skin hinders the effective penetration of siRNA.

Encapsulating Azolates Within Cationic Metal-Organic Frameworks for High-Energy-Density Materials.

Despite the synthesis of numerous cationic metal-organic frameworks (CMOFs), their counter anions have been primarily limited to inorganic Cl, NO , ClO , BF , and CrO , which have weak coordination abilities. In this study, a series of new CMOFs is synthesized using azolates with strong coordination abilities as counter anions, which are exclusively employed as ligands for coordinating with metals. Owing to the unique nitrogen-rich composition of azolates, the CMOFs demonstrate significant potential as high-energy-density materials.

Anti-inflammatory and antioxidant effects on skin based on supramolecular hyaluronic acid-ectoin.

We addressed the damage caused by internal and external factors on the skin, as well as the aging phenomenon caused by delayed repair after damage. We prepared supramolecular hyaluronic acid-ectoin (HA-ECT) by combining theoretical calculations and experimental research, using intermolecular forces between hyaluronic acid and ectoin. This supramolecule has good stability, safety, and skin permeability and can penetrate the stratum corneum of the skin, reaching the epidermis and dermis of the skin.

Integrating intratumoral and peritumoral radiomics with deep transfer learning for DCE-MRI breast lesion differentiation: A multicenter study comparing performance with radiologists.

Purpose: To conduct the fusion of radiomics and deep transfer learning features from the intratumoral and peritumoral areas in breast DCE-MRI images to differentiate between benign and malignant breast tumors, and to compare the diagnostic accuracy of this fusion model against the assessments made by experienced radiologists.

Materials And Methods: This multi-center study conducted a retrospective analysis of DCE-MRI images from 330 women diagnosed with breast cancer, with 138 cases categorized as benign and 192 as malignant. The training and internal testing sets comprised 270 patients from center 1, while the external testing cohort consisted of 60 patients from center 2.

Eutectogel Electrolyte Constructs Robust Interfaces for High-Voltage Safe Lithium Metal Battery.

Dramatic growth of lithium dendrite, structural deterioration of LiCoO (LCO) cathode at high voltages, and unstable electrode/electrolyte interfaces pose significant obstacles to the practical application of high-energy-density LCO||Li batteries. In this work, a novel eutectogel electrolyte is developed by confining the nonflammable eutectic electrolyte in a polymer matrix. The eutectogel electrolyte can construct a robust solid electrolyte interphase (SEI) with inorganic-rich LiF and LiN, contributing to a uniform Li deposition.

Extraction process and characterization of (TKS) latex.

(TKS) latex is a natural latex produced from its root, and its extraction optimization process is mainly studied in the present paper. The composition of fresh roots of TKS was quantitatively analyzed, and the results showed that the moisture content of the fresh root was approximately 70 %, and the rubber content averaged to 6 % (dry weight ratio). An optimal process route for extracting the TKS latex was finally determined, making the extraction efficiency reach about 80 %, and a new latex extraction process was established and optimized and named "the process of Buffer Extraction TKS Latex (BETL)".

A promising perovskite primary explosive.

A primary explosive is an ideal chemical substance for performing ignition in military and commercial applications. For over 150 years, nearly all of the developed primary explosives have suffered from various issues, such as troublesome syntheses, high toxicity, poor stability or/and weak ignition performance. Now we report an interesting example of a primary explosive with double perovskite framework, {(CHN)[Na(NH)(IO)]} (DPPE-1), which was synthesized using a simple green one-pot method in an aqueous solution at room temperature.

Restraint Stress, Foot Shock and Corticosterone Differentially Alter Autophagy in the Rat Hippocampus, Basolateral Amygdala and Prefrontal Cortex.

Autophagy is a conserved lysosomal degradation process that has recently been found to be associated with stress-related psychological diseases. However, previous studies have yielded inconsistent results regarding the effects of various stress patterns on autophagy in different brain regions. This discrepancy may arise from differences in autophagy flux across nuclei, the type of stress experienced, and the timing of autophagy assessment after stress exposure.

Preparation of Rubber and Biofuel Ethanol Simultaneously by the Yeast Fermentation Process.

rubber is considered the most ideal alternative source of natural rubber (NR). Extracting rubber from with high quality, low cost, and low pollution is the basis of commercial development. The roots were subjected to morphological observation and detailed compositional analysis.

Oral Ionic Liquid for Transdermal Delivery and Obesity Treatment.

Obesity is currently a prerequisite for more than 70% of adults, including chronic obesity and long-term obesity. With the increase of diabetes patients in the world, it is urgent to develop effective oral drugs to replace insulin. However, the gastrointestinal tract is a main obstacle to oral drug preparations.

Quantitative Detection of Natural Rubber Content in by Portable Pyrolysis-Membrane Inlet Mass Spectrometry.

gum (EUG) is a natural polymer predominantly consisting of trans-1,4-polyisoprene. Due to its excellent crystallization efficiency and rubber-plastic duality, EUG finds applications in various fields, including medical equipment, national defense, and civil industry. Here, we devised a portable pyrolysis-membrane inlet mass spectrometry (PY-MIMS) approach to rapidly, accurately, and quantitatively identify rubber content in (EU).

The Application of Cinnamon Twig Extract as an Inhibitor of Listeriolysin O against Infection.

As a major virulence factor of (), listeriolysin O (LLO) can assist in the immune escape of , which is critical for the pathogen to evade host immune recognition, leading to various infectious diseases. Cinnamon twig (CT), as a traditional medicine, has been widely used in clinics for multiple functions and it has exhibited excellent safety, efficacy and stability. There are few reports on the effects of the extracts of traditional medicine on bacterial virulence factors.

Influence of relative positions of the heat carrier and lateral canal opening on gutta-percha obturation of lateral canals in a three-dimensional-printed model.

Background/purpose: Effective filling of the lateral canals is of great significance in successful root canal treatment, but it is generally being challenging. This study aimed to evaluate the influence of relative positions of the heat carrier and lateral canal opening on gutta-percha obturation of lateral canals in a three-dimensional (3D)-printed model.

Materials And Methods: Thermal conductivity and real-time temperature transmission of gutta-percha were investigated using laser flash and thermal infrared analyses.

Construction of the first high-density SNP genetic map and identification of QTLs for the natural rubber content in Taraxacum kok-saghyz Rodin.

Background: Taraxacum kok-saghyz Rodin (TKS) is a promising commercial alternative natural rubber (NR) yielding plant. Cultivating TKS with a high NR content is an important breeding target, and developing molecular markers related to NR content can effectively accelerate the breeding process of TKS.

Results: To construct a high-density SNP genetic map and uncover genomic regions related to the NR content in TKS, an F mapping population of TKS was constructed by crossing two parents (l66 and X51) with significant differences in NR contents.

Hyper-Pseudo-Viscoelastic Model and Parameter Identification for Describing Tensile Recovery Stress-Strain Responses of Rubber Components in TBR.

Tires are often in service under dynamic conditions. Realizing the high-precision prediction of the mechanical response of rubber materials under cyclic loading can provide guidance for the design of high-performance tires. In this work, the tensile recovery stress-strain responses of rubber materials in nine different components of a truck and bus radial (TBR) tire were obtained through experiments.

Study on in vitro NR biosynthesis by rapid quantitative determination of substrate depletion.

A convenient and nonradioactive method for quantifying in vitro NR biosynthesis is presented that is based upon the quantitation of substrate depletion by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). NR oligomers could be in vitro biosynthesized with the enzyme source from Hevea brasiliensis (Hevea) or Taraxacum kok-saghyz (TKS) by exogenous monomers (IPP) and initiators (FPP). The IPP incorporation rate and FPP consumption rate were 62.

Prenatal Morphine Exposure Differentially Alters Addictive and Emotional Behavior in Adolescent and Adult Rats in a Sex-Specific Manner.

The effects of prenatal opioid exposure in adult animals has been widely studied, but little is known about the effects of prenatal opioid on adolescents. Most of the risk behaviors associated with drug abuse are initiated during adolescence. The developmental state of the adolescent brain makes it vulnerable to initiate drug use and susceptible to drug-induced brain changes.

Prenatal morphine exposure increases gamma oscillation and theta coherence in the rat reward system.

Previous studies have found that prenatal morphine (PNM) exposure leads to both increased and decreased risk of substance abuse in offspring. Understanding more about the neurobiological changes after the PNM exposure would help to understand more about this issue. Signaling from dopamine neurons of the ventral tegmental area (VTA) in the mesoaccumbal and mesocortical pathways plays a vital role in drug dependency.

Safe and Stable Lithium Metal Batteries Enabled by an Amide-Based Electrolyte.

A novel amide-based nonflammable electrolyte is proposed. The formation mechanism and solvation chemistry are investigated by molecular dynamics simulations and density functional theory. An inorganic/organic-rich solid electrolyte interphase with an abundance of LiF, LiN and Li-N-C is in situ formed, leading to spherical lithium deposition.

Stable Long Cycling of Small Molecular Organic Acid Electrode Materials Enabled by Nonflammable Eutectic Electrolyte.

Small molecule organic acids as electrode materials possess the advantages of high theoretical capacity, low cost, and good processability. However, these electrode materials suffer from poor cycling stability due to the inevitable dissolution of organic molecules in the electrolytes. Here, a eutectic mixture of lithium bis(trifluoromethanesulfonyl)imide and N-methylamine is employed as a eutectic electrolyte in Li-ion batteries with small molecule organic acids as electrodes.