Integrating Activity-Guided Strategy and Fingerprint Analysis to Target Potent Cytotoxic Brefeldin A from a Fungal Library of the Medicinal Mangrove .

Mangrove-associated fungi are rich sources of novel and bioactive compounds. A total of 102 fungal strains were isolated from the medicinal mangrove collected from the South China Sea. Eighty-four independent culturable isolates were identified using a combination of morphological characteristics and internal transcribed spacer (ITS) sequence analyses, of which thirty-seven strains were selected for phylogenetic analysis.

Design, Semisynthesis, Insecticidal and Antibacterial Activities of a Series of Marine-Derived Geodin Derivatives and Their Preliminary Structure-Activity Relationships.

To enhance the biological activity of the natural product geodin (), isolated from the marine-derived fungus sp., a series of new ether derivatives (-) was designed and semisynthesized using a high-yielding one-step reaction. In addition, the insecticidal and antibacterial activities of all geodin congeners were evaluated systematically.

Structure modification, antialgal, antiplasmodial, and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives.

Unlabelled: Marine natural products play critical roles in the chemical defense of many marine organisms and are essential, reputable sources of successful drug leads. Sixty-seven 14-membered resorcylic acid lactone derivatives - and - of the natural product zeaenol () isolated from the marine-derived fungus were semisynthesized by chlorination, acylation, esterification, and acetalization in one to three steps. The structures of these new derivatives were established by HRESIMS and NMR techniques.

Design, semisynthesis, α-glucosidase inhibitory, cytotoxic, and antibacterial activities of p-terphenyl derivatives.

Terphenyllin (1), a naturally abundant p-terphenyl metabolite, was isolated from the coral derived fungus Aspergillus candidus together with four natural analogues 2-5. To evaluate their potency and selectivity, a series of new derivatives of 1 were designed and semisynthesized. They were evaluated for their α-glucosidase inhibitory, cytotoxic, and antibacterial activities.

Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor.

A new centrosymmetric cyclohexapeptide, aspersymmetide A (), together with a known peptide, asperphenamate (), was isolated from the fungus isolated from a gorgonian coral sp., collected from the South China Sea. The chemical structure of was elucidated by analyzing its NMR spectroscopy and MS spectrometry data, and the absolute configurations of the amino acids of were determined by Marfey's method and UPLC-MS analysis of the hydrolysate.

[Characteristics and Mechanism of Copper Adsorption from Aqueous Solutions on Biochar Produced from Sawdust and Apple Branch].

In order to utilize the waste biomass resources efficiently, two raw materials of sawdust and apple branch were selected to produce biochars at 450℃ by oxygen-limited pyrolysis, and the adsorptions of Cu in aqueous solutions were evaluated. The effects of initial Cu concentration and contact time in batch sorption experiments were investigated by the four kinds of isothermal adsorption models (Langmuir, Freundlich, Temkim, D-R model) and the four kinds of adsorption kinetics models (Pseudo first-order, Pseudo second-order, Elovich model, Intraparticle diffusion model). The influencing factors of adsorption characteristics about sawdust biochar (JB) and apple branch biochar (PB) were discussed by characterizing their elemental composition, functional groups, surface area, surface morphology and scanning electron microscope.

Aspergivones A and B, two new flavones isolated from a gorgonian-derived Aspergillus candidus fungus.

Two new flavones, aspergivones A (1) and B (2), were isolated from the fungus Aspergillus candidus cultured from the gorgonian coral Anthogorgia ochracea collected from the South China Sea. The structures of 1 and 2 were elucidated by NMR and MS methods and comparison with relatively known compounds. Only 2 showed slight inhibitory activity against alpha-glucosidase with an IC value of 244 μg/mL.

[Effect of Biochar on Soil Greenhouse Gas Emissions in Semi-arid Region].

This study aimed to investigate the effects of biochar addition on the emission of greenhouse gases from farmland soil in semi-arid region. Through an in-situ experiments, the influence of sawdust biochar(J) and locust tree skin biochar (H) at three doses (1%, 3%, and 5% of quality percentage) on C2, CH4 and N2O emissions were studied within the six months in the south of Ningxiaprovince. The results indicated that soil CO2 emission flux was slightly increased with the addition doses for both biochars, and the averaged CO2 emission flux for sawdust and locust tree skin biochar was enhanced by 1.

[Effects of biochar addition into soils in semiarid land on water infiltration under the condition of the same bulk density].

Making clear the effects of biochar addition on soil water infiltration process can provide the scientific basis for the evaluation of the influence of biochar application on soil hydrology in semi-arid region. In this paper, through the soil column simulation method in laboratory, the effects of biochar of three sizes (1-2 mm, 0.25-1 mm and ≤ 0.