Publications by authors named "Ji-ying Wen"
Preeclampsia (PE), a pregnancy-specific syndrome, has been associated with the gut bacteriome. Here, to investigate the impact of the gut virome on the development of PE, we identified over 8,000 nonredundant viruses from the fecal metagenomes of 40 early-onset PE and 37 healthy pregnant women and profiled their abundances. Comparison and correlation analysis showed that PE-enriched viruses frequently connected to species enriched in PE.
View Article and Find Full Text PDFDeep metagenomic characterization of gut microbial community and function in preeclampsia.
Front Cell Infect Microbiol
October 2022
Preeclampsia (PE) is a pregnancy complication characterized by severe hypertension and multiple organ damage. Gut microbiota has been linked to PE by previous amplicon sequencing studies. To resolve the PE gut microbiota in a higher taxonomy resolution, we performed shotgun metagenomic sequencing on the fecal samples from 40 early-onset PE and 37 healthy pregnant women.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to determine specific ambulatory blood pressure (BP) thresholds for diagnosing hypertension in pregnant women, particularly using data from a southern Chinese population, rather than relying on standard clinic BP measurements.
- - Researchers monitored 1,768 high-risk pregnant participants, identifying new BP thresholds linked to adverse maternal and neonatal outcomes, with key figures being 130/80 mm Hg for daytime, 120/75 mm Hg for nighttime, and 130/75 mm Hg for 24-hour assessments.
- - The findings suggest that these new thresholds are lower than traditional clinic BP benchmarks (140/90 mm Hg) and highlight the need for further international studies to enhance the understanding and application of ambulatory BP monitoring in pregnancy. *
Background: The associations between umbilical cord coiling, feto-placental vascular resistance and maternal blood pressure (BP) are not well understood.
Method: We retrospectively analyzed 502 pregnant women suspected of hypertensive disorders in the third trimester from a hospital-based cohort, who underwent ambulatory BP monitoring and umbilical artery Doppler velocimetry examinations within 14 days before delivery. By applying quantile regression, a significant quantile-dependent positive association between umbilical cord coiling index and umbilical artery pulsatility index (UAPIMOM; converted to multiples of median) was observed from above 0.
The nonstratification of blood pressure (BP) levels may underestimate future cardiovascular risk in pregnant women who present with BP levels in the range of prehypertension (120-139/80-89 mm Hg). We prospectively evaluated the relationship between multiple antepartum BP measurements (from 11(+0) to 13(+6) weeks' gestation to term) and the occurrence of postpartum metabolic syndrome in 507 normotensive pregnant women after a live birth. By using latent class growth modeling, we identified the following 3 distinctive diastolic BP (DBP) trajectory groups: the low-J-shaped group (34.
View Article and Find Full Text PDF[Evaluation of the diagnostic criteria of gestational metabolic syndrome and analysis of the risk factors].
Zhonghua Fu Chan Ke Za Zhi
February 2013
Objectives: To investigate gestational multiple metabolic abnormalities aggregation and diagnostic criteria for gestational metabolic syndrome (GMS), and to analyze the risk factors of GMS.
Methods: A cohort study recruiting 309 pregnant women with preeclampsia, 627 pregnant women with gestational diabetes mellitus (GDM) and 1245 normal pregnant women was performed from January 2008 to December 2011 in Guangdong Women and Children's Hospital. Information regarding age, gestational weeks, basic blood pressure, admission blood pressure, height and body mass index(BMI)before pregnancy was recorded.