Research on Correlations of lncRNA ST7-AS1 with Progression and Therapeutic Targets of Esophageal Cancer.

Esophageal cancer is a highly prevalent gastrointestinal tumor in China, resulting in a significant number of deaths annually. In this paper, we investigated the regulatory role and therapeutic potential of aberrant ST7-AS1 expression in esophageal cancer. The presence of ST7-AS1 in 125 esophageal cancer tissues was identified through RT-qPCR assays.

CircLPHN3 correlates with prognosis in colorectal cancer and regulates cellular processes by targeting miR-142-5p.

Background: Colorectal cancer (CRC) is often diagnosed late and has a poor prognosis. Circular RNAs (circRNAs) have been identified as prognostic biomarkers in various cancers, including CRC.

Objective: The objective was to elucidate the role of circLPHN3 (hsa_circ_0069865) in CRC progression and to provide a promising prognostic marker for CRC.

Spatial-temporal characteristics and driving factors' contribution and evolution of agricultural non-CO greenhouse gas emissions in China: 1995-2021.

Comprehending the spatial-temporal characteristics, contributions, and evolution of driving factors in agricultural non-CO greenhouse gas (GHG) emissions at a macro level is pivotal in pursuing temperature control objectives and achieving China's strategic goals related to carbon peak and carbon neutrality. This study employs the Intergovernmental Panel on Climate Change (IPCC) carbon emissions coefficient method to comprehensively evaluate agricultural non-CO GHG emissions at the provincial level. Subsequently, the contributions and spatial-temporal evolution of six driving factors derived from the Kaya identity were quantitatively explored using the Logarithmic Mean Divisia Index (LMDI) and Geographical and Temporal Weighted Regression (GTWR) methods.

The preparation, characterization, and application of porous core-shell composite particles produced with laboratory-scale spray dryer.

Objective: To prepare porous core-shell composite particles (PCPs) in order to improve the flowability and compactibility of powder materials for direct compaction (DC), as well as the dissolution of tablets.

Significance: The results obtained are meaningful to boosting the development and further research of PCPs on DC. Methods: In this study, hydroxypropyl methylcellulose (HPMC E3) and polyvinylpyrrolidone (PVP K30) were selected as shell materials, the Xiao Er Xi Shi formulation powder (XEXS) was used as the core materials, ammonium bicarbonate (NHHCO), and sodium bicarbonate (NaHCO) were employed as pore-forming agent.

Chrysanthemum sporopollenin: A novel vaccine delivery system for nasal mucosal immunity.

Objective: Mucosal immunization was an effective defender against pathogens. Nasal vaccines could activate both systemic and mucosal immunity to trigger protective immune responses. However, due to the weak immunogenicity of nasal vaccines and the lack of appropriate antigen carriers, very few nasal vaccines have been clinically approved for human use, which was a major barrier to the development of nasal vaccines.

Surface Modifiers on Composite Particles for Direct Compaction.

Direct compaction (DC) is considered to be the most effective method of tablet production. However, only a small number of the active pharmaceutical ingredients (APIs) can be successfully manufactured into tablets using DC since most APIs lack adequate functional properties to meet DC requirements. The use of suitable modifiers and appropriate co-processing technologies can provide a promising approach for the preparation of composite particles with high functional properties.

Improvement and Performance Evaluation of a Dual-Probe Heat Pulse Distributed Temperature Sensing Method Used for Soil Moisture Estimation.

Large-scale measurements of soil moisture play a critical role in many fields, such as agriculture, hydrology, and engineering. The distributed temperature sensing (DTS) technology, based on a dual-probe heat pulse (DPHP), is a novel approach to realizing large-scale soil moisture estimation. However, the application of the method is limited by the complex optical cable layout, calculation algorithm, and lack of standardized heating strategy.

Synthesis and insecticidal activities of 4-(propargyloxy) benzenesulfonamide derivatives.

A series of 4-(propargyloxy) benzenesulfonamide derivatives with different substituents on the benzene ring were synthesized and evaluated for their insecticidal activity. Some of the compounds showed good insecticidal activity against , and the LC value of the most active compound was 0.235 mg/ml.

Simulation Research on Continuous Concrete Beams Reinforced with External Prestressed CFRP Tendons.

This paper examines the effects of different loading patterns on the static characteristics of continuous concrete beams reinforced with external prestressed carbon fiber-reinforced polymer tendons (EPCFRPT) and qualitatively analyzes the results for two continuous concrete beams: SB-1 under symmetrical loading, and SB-2 under asymmetrical loading. Then, a finite element analysis model is introduced and calibrated by tests conducted at Southeast University and data collected from a literature review. Based on the FEA model, the initial prestress, cross-section area, and eccentricity of CFRP tendons as well as the steel reinforcement configuration were selected by a parametric study.

Design, synthesis and insecticidal activities of 4-propargyloxybenzene sulfonamide derivatives substituted with amino acids.

Sixty-nine 4-propargyloxybenzene sulfonamide derivatives with different amino acids as amino substituent were synthesized and evaluated for their insecticidal activity against third-instar . The bioassay results revealed that some derivatives bearing amino acid ester group performed good insecticidal activity against third-instar , such as the LC values of and were 4.28 and 2.

[Effects of Microplastic Exposure on Crucian Growth, Liver Damage, and Gut Microbiome Composition].

Microplastics (MPs), which are widely present in the natural environment, may be harmful to the growth and health of aquatic organisms, though studies in this area are lacking. In this study, the crucian carp (), a type of omnivorous freshwater fish, was chosen as the target, which was fed with fish food containing different concentrations of MPs for a 30-day food exposure experiment to study the effects of MPs on crucian growth, liver damage, and gut microbiome composition. Compared with that in the control group, the body length of the crucians in the environmental groups did not change significantly.

Short-term air quality forecasting model based on hybrid RF-IACA-BPNN algorithm.

Despite the apparent improvement in air quality in recent years through a series of effective measures, the concentration of PM and O in Chengdu city remains high. And both the two pollutants can cause serious damage to human health and property; consequently, it is imperative to accurately forecast hourly concentration of PM and O in advance. In this study, an air quality forecasting method based on random forest (RF) method and improved ant colony algorithm coupled with back-propagation neural network (IACA-BPNN) are proposed.

Design, synthesis, and insecticidal activities of propargyloxy-naphthalene-sulfonamide derivatives.

In our previous studies, a kind of novel benzenesulfonamides was found to be a candidate insecticidal compounds. It was shown that propargyloxy and sulfonamide groups are pharmacodynamic groups. One hundred and twenty-six (126) naphthalenesulfonamides derivatives with propargyloxy functionality were designed and synthesized, and their insecticidal activities were determined.

Pgc-1α Promotes Phosphorylation, Inflammation, and Apoptosis in H9c2 Cells During the Early Stage of Lipopolysaccharide Induction.

Cardiac dysfunction in severe sepsis is associated with increased mortality. However, the molecular mechanisms underlying septic heart dysfunction remain unclear. Expression of peroxisome proliferator-activated receptor-γ coactivator 1α (Pgc-1α), concentrations of inflammatory factors, and activation of the nuclear factor kappa-B (NF-κB) signaling pathway were examined in H9c2 cells after a 24-h lipopolysaccharide (LPS) stimulation period using qPCR, enzyme-linked immunosorbent assays (ELISAs), and western blots (WBs), respectively.

Prevalence of burnout in mental health nurses in China: A meta-analysis of observational studies.

Objective: Burnout is common in mental health nurses because of work-related stress. Burnout has a negative impact on nurses' health and work performance. The prevalence of high burnout in mental health nurses has been inconclusive across studies.

Assessment of inflammatory markers and mitochondrial factors in a rat model of sepsis-induced myocardial dysfunction.

The present study aimed to investigate the expression of inflammatory markers and mitochondrial function-related genes, as well as their temporal relationship with cardiac myocyte injury in a rat model of sepsis. The sepsis model was constructed using cecal ligation and puncture (CLP). Two hours after CLP, the levels of inflammatory cytokines (interleukin [IL]-1β, IL-6, and TNFα) and myocardial function markers (serum brain natriuretic peptide [BNP], cardiac troponin-I [cTNI], and procalcitonin [PCT]) were increased significantly, falling from around 9 hours postoperatively.

Obesity increases the risk of depression in children and adolescents: Results from a systematic review and meta-analysis.

Background: Clinical depression (including major depression, dysthymia, and unspecified depression) is common in children and adolescents with obesity and overweight. The objective of this systematic review and meta-analysis was to examine prevalence of clinical depression among overweight and obese children.

Methods: PubMed, EMBASE, Web of Science, Medline, Cochrane library, and PsycINFO databases were systematically and independently searched by three researchers from the inception dates to April 01, 2019.

Prevalence of smoking in nursing students worldwide: A meta-analysis of observational studies.

Background: Smoking is common among nursing students worldwide, but the reported prevalence is inconsistent across epidemiological studies. This is a meta-analysis of the prevalence of smoking in nursing students worldwide.

Design: Meta-analysis of observational studies.

Prevalence of sexual harassment of nurses and nursing students in China: a meta-analysis of observational studies.

Sexual harassment experienced by nurses and nursing students is common and significantly associated with negative consequences. This study is a meta-analysis of the pooled prevalence of sexual harassment of nurses and nursing students in China. Electronic databases (PubMed, EMBASE, PsycINFO, Web of Science and Ovid, China National Knowledge Internet, WanFang, SinoMed and Chinese VIP Information) were independently and systematically searched by two reviewers from their commencement date to 12 March 2018.

Prevalence of depressive symptoms in overweight and obese children and adolescents in mainland China: A meta-analysis of comparative studies and epidemiological surveys.

Background: Obesity is associated with a higher risk of depression in children and adolescents. This is a meta-analysis of studies examining depressive symptoms in overweight and obese children and adolescents in China.

Methods: A systematic literature search was performed independently in both English (PubMed, EMBASE, Web of Science and Medline Complete) and Chinese (China National Knowledge Internet, WANFANG Data and WeiPu VIP) databases from their commencement date to December 31, 2018.

Worldwide prevalence of falls in older adults with psychiatric disorders: A meta-analysis of observational studies.

Falls are common in older adults with psychiatric disorders, but the epidemiological findings have been inconsistent. This meta-analysis examined the prevalence of falls in older psychiatric patients and its moderating factors. PubMed, EMBASE, Web of Science and PsycINFO databases were independently searched by three investigators from their inception date to Nov 31, 2017.

Antifungal, anti-inflamatory and neuritogenic activity of newly-isolated compounds from .

A new ester () and a terpenoid () were isolated from the dried whole plant of (H) E. ex D for the first time and their structures were elucidated, as well as their biological activities are described. The two compounds all showed good antifungal activities, especially furanone () exhibited better antifungal activity against and with EC value of 22.

[Response of volatiles of Artemisiae Argyi Folium to climatic factors].

Combined headspace solid-phase microextraction with gas chromatography-mass spectrometry (HS-SPME-GC-MS), this paper studied the volatiles of Artemisiae Argyi Folium that respectively collected from Kongdong, Huanglong, Ankang, Qichun and Tongbai，and then explored the influence of climatic factors on the main components of the volatiles. The results showed that 54, 52, 57, 47 and 55 compounds were respectively identified from the leaves from five regions, mainly consist of monoterpenes, sesquiterpenoids and their oxygen-containing derivatives, a few aldehydes, alkanes and benzenes. It is different that the volatiles of Artemisiae Argyi Folium that collected in different habitats, neither composition nor content.