[A cohort study on the relationship between cerebrovascular hemodynamic changing and risk of stroke].

Objective: To study the role of cerebrovascular hemodynamic indexes (CVHI) changing in stroke and to provide reference for stroke prevention and risk factor study.

Methods: From 2003 to 2004, participants aged 40 years and above in two communities in Fengxian district were recruited by cluster sampling. Risk factors of stroke and CVHI were investigated and checked during baseline investigation.

[Study on over-weight, obesity and the exposure to stroke risk factors among 40 year olds and over in a community-based population].

Objective: To describe the distribution of over weight and obesity to discover the level of exposure on risk factors of stroke among people aged 40 and over, in a community-based population.

Methods: From 2003 to 2004, people aged > or = 40 years in a community of Fengxian district in Shanghai were selected by cluster sampling. Out of 11,791 individuals who were selected, 10,565 met the inclusion criteria and responded to the investigation.

[Baseline study and analysis on a stroke risk factor-related cohort in Fengxian county of Shanghai].

Objective: To explore the exposed level of stroke risk factors in Fengxian county of Shanghai and the relationships between risk factors and stroke.

Methods: Community based populations including 10,565 individuals aged 40 years old and over were cluster sampled from Fengxian county in 2003 or 2004. Status of exposure on common risk factors such as hypertension, cardiovascular disease, diabetes, family history of stroke, cigarette smoking, alcohol intake were gathered while cerebral vascular hemodynamic index (CVHI) was examined, with CVHI score below 75 points as abnormal.

High-level expression, purification and characterization of recombinant Aspergillus oryzae alkaline protease in Pichia pastoris.

The alkaline protease gene from Aspergillus oryzae was cloned, and then it was successfully expressed in the heterologous Pichia pastoris GS115 with native signal peptide or alpha-factor secretion signal peptide. The yield of the recombinant alkaline protease with native signal peptide was about 1.5-fold higher than that with alpha-factor secretion signal peptide, and the maximum yield of the recombinant alkaline protease was 513 mg/L, which was higher than other researches.

[Baseline study on a stroke-related cohort in the rural community of Shanghai].

Objective: To present data from a baseline investigation on stroke-related cohort population in rural area of Shanghai.

Methods: A cross-sectional study was carried out in a cluster sampling population aged 40 years and over. General information and data on common risk factors in the population were gathered and cerebral vascular hemodynamic indexes were checked.

[Effectiveness of Nao'an Capsule on stroke prevention among high risk population in Nanhui, Shanghai].

Objective: To evaluate the effectiveness of stroke prevention among high risk population, using Nao'an Capsules.

Methods: Participants were selected from 696,558 residents in Nanhui, using county of Shanghai city. Individuals aged 35 years old and over with at least one risk factor exposure to stroke, received cerebral vascular hemodynamic examination.

[The reference range of cerebrovascular hemodynamics indexes parameters].

Objective: To study the reference range of cerebrovascular hemodynamics indexes (CVHI) in a sampling population.

Methods: Fourteen thousand, four hundred and eighty participants without history of stroke or exposure to risk factors were screened from 26 cities in Northeast China, North China, East China, Northwest China, South China, and Southwest China in the prospective study on stroke intervention. CVHI were checked and 95% confidence intervals were calculated using normal distribution methods, which were grouped by age, sex, area, and check positions.

[Changes of cerebral vascular hemodynamics from normal population to stroke].

Objective: To probe into changes of cerebral vascular hemodynamics indexes (CVHI) from normal population to different clinical stage before and after occurring of stroke.

Methods: Participants were selected from 25,355 stroke cohort study population aged 35 years and over in Northeast of China and 55 acute stroke patients were selected from Fuzhou PLA General Hospital. CVHI indexes were checked during baseline investigation or within one week after acute stroke.