Dihydroartemisinin Affects STAT3/DDA1 Signaling Pathway and Reverses Breast Cancer Resistance to Cisplatin.

Dihydroartemisinin (DHA) has anticancer effects on multiple tumors, including those associated with breast cancer. This study aimed to investigate the mechanism causing DHA-reversing cisplatin (DDP) resistance in breast cancer. Relative mRNA and protein levels were tested using a qRT-PCR and western blot assay.

Nobiletin promotes the pyroptosis of breast cancer via regulation of miR-200b/JAZF1 axis.

Nobiletin is a polymethoxylated flavone present in citrus fruits, which has been reported to have inhibitory effects on tumorigenesis of cancers. However, the biological function of nobiletin in breast cancer (BC) is largely unknown. To investigate the effect of nobiletin on growth of BC cells, the cell viability of BC was measured by MTT assay.

Stripe and supersolid phases of spin-orbit coupled spin-2 Bose-Einstein condensates in an optical lattice.

We study the ground-state phases of two-dimensional spin-orbit coupled spin-2 Bose-Einstein condensates in a one-dimensional spin-dependent optical lattice. Due to the competition among optical lattice, spin-orbit coupling and spin-exchange interaction, the exotic ground-state phases are found, i.e.

Ground-state phases of spin-orbit coupled spin-1 Bose-Einstein condensate in a plane quadrupole field.

We study the ground-state phases of two-dimensional spin-orbit coupled spin-1 Bose-Einstein condensate loaded in a plane quadrupole field. In the absence of rotation, for the fixed spin-orbit coupling strength, the ordinary stripe phase is found when the strength of the magnetic field gradient is small. As the strength of magnetic field gradient enhances, the system realizes the phases with three layer vortices along the radial direction.

Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity.

In chondrocytes, resveratrol, a natural SIRT1 activator, exerts an anti-inflammatory response via inhibition of nuclear factor kappaB (NF-κB). Given that SIRT1 inhibits the transactivation potential of NF-κB by deacetylating acetylated lysines in p65, the NF-κB subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes. We found that when chondrocytes were stimulated with interleukin 1β (IL-1β), the time- and dose-dependent expression of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production was suppressed by resveratrol.

Endoplasmic reticulum stress induced by tunicamycin and antagonistic effect of Tiantai No.1 (1) on mesenchymal stem cells.

Objective: Changes of the internal and external cellular environments can induce calcium homeostasis disorder and unfolded protein aggregation in the endoplasmic reticulum (ER). This ER function disorder is called endoplasmic reticulum stress (ERS). Severe long-term ERS can trigger the ER apoptosis signaling pathway, resulting in cell apoptosis and organism injury.

Diagnostic model of saliva protein finger print analysis of patients with gastric cancer.

Aim: To explore the method for early diagnosis of gastric cancer by screening the expression spectrum of saliva protein in gastric cancer patients using mass spectrometry for proteomics.

Methods: Proportional peptide mass fingerprints were obtained by analysis based on proteomics matrix-assisted laser desorption ionization time-of-flight/mass spectrometry. A diagnosis model was established using weak cation exchange magnetic beads to test saliva specimens from gastric cancer patients and healthy subjects.