Effects of Pectus Excavatum on the Spine of Pectus Excavatum Patients with Scoliosis.

Background: There is high risk in the correction surgery of pectus excavatum with scoliosis because of the lack of the correction mechanism of pectus excavatum with scoliosis. This study performed a comprehensive analysis about the impact that pectus excavatum had on scoliosis and elaborated its biomechanical mechanism in pectus excavatum patients with scoliosis.

Methods: 37 pectus excavatum patients were selected.

Numerical Simulation and Clinical Verification of the Minimally Invasive Repair of Pectus Excavatum.

Objective: In this article we proposed a modeling method by building an assembled model to simulate the orthopedic process of minimally invasive surgery for pectus excavatum and got the clinical verification, which aims to provide some references for clinic diagnoses, treatment, and surgery planning.

Methods: The anterior chest model of a 15-year-old patient was built based on his CT images; and his finite element model and the Nuss bar were created. Coupling of nodal displacement was used to connect bones with cartilages of the anterior chest.

Depleting NFAT1 expression inhibits the ability of invasion and migration of human lung cancer cells.

Background: Nuclear factor of activated T-cells (NFAT) is a general name applied to a family of transcription factors shown to be important in immune response. One or more members of the NFAT family are expressed in most cells of the immune system. NFAT1 is considered to involve in the development of cardiac, skeletal muscle, nervous systems, and tumorigenesis.

Early results of 18 adults, following a modified Nuss operation for recurrent pectus excavatum.

Objectives: The minimally-invasive Nuss operation has been widely used for correcting pectus excavatum in children. However, a number of adult patients require reoperations for recurrence or other complications. This work aimed to investigate the early results of recurrent pectus excavatum repair using a modified Nuss procedure, which were seldom reported in adult patients.

Acute respiratory distress caused by esophageal duplication canceration in an adult.

Esophageal duplication (ED) in adults is rare, and ED canceration is very rare. We report a case of acute respiratory embarrassment caused by ED with squamous carcinoma in a 39-year-old man and a review of the literature.

Tumor with watery diarrhoea, hypokalaemia in a 3-year-old girl.

Watery diarrhoea, hypokalaemia and achlorhydria (WDHA) syndrome was caused by vasoactive intestinal polypeptide (VIP)-producing tumour. A 3-year-old Chinese girl with watery diarrhoea, abdominal distension and hypokalaemia due to a thoracic paraspinal VIP-secreting ganglioneuroma is reported. The girl coughed, fevering up to 39 degrees C after a flu-like episode.

[Diagnosis and treatment of pulmonary aspergillosis in patients without immunodeficiency: report of 15 cases].

Objective: To study the diagnosis and treatment of pulmonary aspergillosis in patients without immunodeficiency.

Method: Pulmonary aspergillosis in 15 patients without immunodeficiency was reviewed.

Results: Twelve of the patients had underlying lung diseases (lung cancer), 2 showed masses in the lung by radiography and CT halo, and 1 had aspergilloma within the left main bronchus.

[Identification and clinical evaluation of lung cancer serum biomarker L-lactate dehydrogenase B].

Objective: To identify potential biomarkers related with lung cancer metastasis.

Methods: Conditional media proteins collected from a primary non-small cell lung cancer cell line (NSCLC) NCI-H226 and its brain metastatic subline H226Br were analyzed by SDS-PAGE and MALDI-TOF-MS. Twelve biomarkers were identified, of which LDHB was significantly up-regulated in H226Br cell and was further validated using ELISA in sera including 105 lung cancer samples, 41 pneumonia and pulmonary tuberculosis samples and 65 healthy samples.

[The study on freezing intercostal nerves for the relief of postoperative chest pain].

Objective: To explore the best freezing time and the optimum analgesia modality.

Methods: In dogs, intercostal nerves were froze at -70 degrees C at different time including 30, 60, 90, 120, 180 s. Samples were got at the operative day, in 10 days and 60 days respectively, then carried on the pathology exam.

Discovery and identification of Serum Amyloid A protein elevated in lung cancer serum.

Two hundred and eighteen serum samples from 175 lung cancer patients and 43 healthy individuals were analyzed by using Surface Enhaced Laser Desorption/Ionization Time of Flight Mass Spectrome-try (SELDI-TOF-MS). The data analyzed by both Biomarker Wizardtrade mark and Biomarker Patternstrade mark software showed that a protein peak with the molecular weight of 11.6 kDa significantly increased in lung cancer.

Serum amyloid A protein: a potential biomarker correlated with clinical stage of lung cancer.

Objective: To identify serum diagnosis or progression biomarkers in patients with lung cancer using protein chip profiling analysis.

Method: Profiling analysis was performed on 450 sera collected from 213 patients with lung cancer, 19 with pneumonia, 16 with pulmonary tuberculosis, 65 with laryngeal carcinoma, 55 with laryngopharyngeal carcinoma patients, and 82 normal individuals. A new strategy was developed to identify the biomarkers on chip by trypsin pre-digestion.

[Analyzing chromosomal abnormality in primary esophageal cancer by comparative genomic hybridization].

Background & Objective: Some researches have showed that chromosomal abnormalities, including chromosomal regions of gains and losses, usually occur in primary esophageal cancer. The comparative genomic hybridization (CGH) technique can show chromosomal abnormality. This study was to analyze the characteristics of chromosomal abnormity in primary esophageal cancer by CGH, and explore its correlation to prognosis.