[Mutations of p53 gene in 41 cases of human brain gliomas].

Background & Objective: p53 gene plays an important role in regulating cell cycle, maintaining completeness of cellular genomes, inducing cell differentiation and apoptosis. p53 gene mutation occurs usually in gliomas, especially astrocytomas. This study was to investigate p53 gene mutation and its correlation to the development of glioma.

[Expression of CGRP, ACTH and 5-HT in normal human lymph nodes].

Aim: To detect the expression of calcitonin-gene-related peptide (CGRP), adrenocorticotropin (ACTH), and serotonin (5-HT) in normal human lymph nodes and explore their influences on immune system.

Methods: The expression of CGRP, ACTH and 5-HT in the lymph nodes, including proliferative lymph nodes, were detected by SABC Immunohistochemical staining.

Results: In 35 cases of lymph node specimens, the positive rates of CGRP, ACTH and 5-HT expression were 88.