5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma.

The development of chemoresistance may reduce the efficacy of chemotherapeutic drugs for treating hepatocellular carcinoma (HCC). In the present study, the effects of apigenin on intensifying the chemosensitivity of HCC cells and an HCC xenograft model in response to 5-fluorouracil (5-FU) were investigated. Sub-toxic concentrations of apigenin (4 μmol/L) significantly enhanced the cytotoxicity of 5-FU (100 μg/mL) in HCC cells.

Regularly shaped, single-crystalline ZnO nanorods with Wurtzite structure.

A convenient route at ambient conditions was employed to prepare narrow-dispersed ZnO nanorods in terms of size and morphology. Transmission electron microscopy and X-ray diffraction were used to characterize the structurally uniform and well-proportioned products. The as-prepared specimen exhibits strong ultraviolet exciton emission at 385 nm and disappearance of visible defect emission.