Publications by authors named "Ji-Yun Kim"

Background: RNA modifications, a central aspect of epitranscriptomics, add a regulatory layer to gene expression by modifying RNA function without altering nucleotide sequences. These modifications play vital roles across RNA species, influencing RNA stability, translation, and interaction dynamics, and are regulated by specific enzymes that add, remove, and interpret these chemical marks.

Objective: This review examines the role of aberrant RNA modifications in cancer progression, exploring their potential as diagnostic and prognostic biomarkers and as therapeutic targets.

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• Induction of SWEET sugar transporters by bacterial pathogens via transcription activator-like (TAL) effectors is necessary for successful blight infection of rice, cassava and cotton, - likely providing sugars for bacterial propagation. • Here, we show that infection of by the necrotrophic fungus causes increased accumulation of amino acid transporter UmamiT20 mRNA in leaves. UmamiT20 protein accumulates in leaf veins surrounding the lesions after infection.

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Article Synopsis
  • COVID-19, caused by the SARS-CoV-2 virus, emerged globally in 2019, impacting health and the economy, leading to the development of various vaccine types.
  • Researchers tested an intranasal vaccine using a Newcastle disease virus vector expressing the SARS-CoV-2 Beta variant spike protein in mice, finding it effective against subsequent viral challenges.
  • The study showed that intranasal vaccination induced strong mucosal immunity and high survival rates, suggesting it could be a promising candidate for protecting against COVID-19.
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Arterial macrophage cholesterol accumulation and impaired cholesterol efflux lead to foam cell formation and the development of atherosclerosis. Modified lipoproteins interact with toll-like receptors (TLR), causing an increased inflammatory response and altered cholesterol homeostasis. We aimed to determine the effects of TLR antagonists on cholesterol efflux and foam cell formation in human macrophages.

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Objectives: To create bacteria-resistant dental CAD-CAM blocks with a biofilm-resistant effect by incorporating Nano-crystalline ceramic and polymer (NCP) with 2-methacryloyloxyethyl phosphorylcholine (MPC) and sulfobetaine methacrylate (SBMA) and at an equimolar ratio, referred to as MS.

Methods: Experimental groups comprised NCP blocks containing zwitterions at 0.15wt% (MS015) and 0.

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Article Synopsis
  • A Newcastle disease virus (NDV)-vectored vaccine, rK148/22-H5, was developed to protect against H5N1 avian influenza in chickens and ducks.
  • The vaccine provided complete survival and significantly reduced viral shedding in specific pathogen-free (SPF) chickens, and also offered good protection in broilers and domestic ducks with maternally derived antibodies.
  • rK148/22-H5 serves as a promising biosecurity measure against the deadly H5 HPAI strain, aligning with strategies to differentiate between infected and vaccinated animals.
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  • The study investigates the relationship between TFE3 and the PI3K/Akt pathway in renal cell carcinoma (RCC), focusing on how TFE3 expression is linked to cancer progression and patient prognosis.
  • TFE3 was manipulated in UOK146 cells using siRNA, shRNA, and pcDNA3.1 to assess its effect on phospho-Akt levels when treated with mTOR and PI3K inhibitors.
  • Results showed that TFE3 down-regulation increased phospho-Akt expression, while its up-regulation decreased it, suggesting that targeting the PI3K/Akt pathway could improve RCC treatment by impacting the tumor microenvironment.
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Infectious bronchitis virus (IBV), an avian coronavirus, has caused considerable damage to the poultry industry. In Korea, indigenous KM91-like and newly introduced QX-like lineages belonging to the GI-19 lineage have been prevalent despite constant vaccination. In this study, complete genome sequences of 23 IBV isolates in Korea from 2010 to 2020 were obtained using next-generation sequencing, and their phylogenetic relationship and recombination events were analyzed.

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The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the emergency of various lineages through mutations and recombination. In the Delta lineage, we identified recombination events in the ORF1a gene, which divided the Delta sublineages into three different genotypes (Delta R1-R3). The regional distributions of Delta R1 and Delta R2 were not correlated, indicating that recombination occurred early in the Delta outbreak.

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Avian influenza viruses (AIVs) in wild birds are phylogenetically separated in Eurasian and North American lineages due to the separated distribution and migration of wild birds. However, AIVs are occasionally dispersed between two continents by migratory wild birds flying across the Bering Strait. In this study, we isolated three AIVs from wild bird feces collected in South Korea that contain gene segments derived from American lineage AIVs, including an H6N2 isolated in 2015 and two H6N1 in 2017.

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Coronavirus disease 2019 (Covid-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) became a pandemic, causing significant burden on public health worldwide. Although the timely development and production of mRNA and adenoviral vector vaccines against SARS-CoV-2 have been successful, issues still exist in vaccine platforms for wide use and production. With the potential for proliferative capability and heat stability, the Newcastle disease virus (NDV)-vectored vaccine is a highly economical and conceivable candidate for treating emerging diseases.

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Following the global emergence of the SARS-CoV-2 Alpha variant of concern (VOC) in 2020, the Delta variant triggered another wave in 2021. The AY.69 lineage, a Delta VOC, was particularly prevalent in Republic of Korea (South Korea) from May 2021 to January 2022, despite the synchronized implementation of vaccination programmes and non-pharmaceutical interventions (NPIs) such as social distancing.

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Posttraumatic growth (PTG) is a positive psychological change experienced after trauma and it has gained global recognition in recent years. The present study aimed to validate a South Korean version of the Posttraumatic Growth Inventory-Expanded (K-PTGI-X) for use with trauma-exposed and bereaved samples. A national sample comprising South Korean adults was used for the analysis.

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In this study, the Convolution Neural Network (CNN) algorithm is applied for non-destructive evaluation of aluminum panels. A method of classifying the locations of defects is proposed by exciting an aluminum panel to generate ultrasonic Lamb waves, measuring data with a sensor array, and then deep learning the characteristics of 2D imaged, reflected waves from defects. For the purpose of a better performance, the optimal excitation location and sensor locations are investigated.

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The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic since 2019. Variants of concern (VOCs) declared by the World Health Organization require continuous monitoring because of their possible changes in transmissibility, virulence, and antigenicity. The Omicron variant, a VOC, has become the dominant variant worldwide since November 2021.

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Resistance to hypomethylating agents (HMAs) in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) is a concerning problem. Polo-like kinase 1 (PLK1) is a key cell cycle modulator and is known to be associated with an activation of the PI3K pathway, which is related to the stabilization of DNA methyltransferase 1 (DNMT1), a target of HMAs. We investigated the effects of volasertib on HMA-resistant cell lines (MOLM/AZA-1 and MOLM/DEC-5) derived from MOLM-13, and bone marrow (BM) samples obtained from patients with MDS (BM blasts >5%) or AML evolved from MDS (MDS/AML).

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Acute myeloid leukemia (AML) is an aggressive blood cancer with a high rate of relapse associated with adverse survival outcomes, especially in elderly patients. An aberrant expression of cyclin dependent kinase 7 (CDK7) is associated with poor outcomes and CDK7 inhibition has showed antitumor activities in various cancers. We investigated the efficacy of YPN-005, a CDK7 inhibitor in AML cell lines, xenograft mouse model, and primary AML cells.

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During multicellularization, plants evolved unique cell-cell connections, the plasmodesmata (PD). PD of angiosperms are complex cellular domains, embedded in the cell wall and consisting of multiple membranes and a large number of proteins. From the beginning, it had been assumed that PD provide passage for a wide range of molecules, from ions to metabolites and hormones, to RNAs and even proteins.

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Article Synopsis
  • The study investigates how genomic epidemiology was used to analyze the spread of SARS-CoV-2 in South Korea by examining viral genome sequences from over 2,000 cases during 2020.
  • The analysis found that while most imported cases from travelers did not spread widely, four viral subgroups caused local outbreaks, which were eventually controlled after enhanced social distancing measures were implemented.
  • The results suggest that South Korea's traveler quarantine and social distancing strategies were effective in reducing virus spread, but further improvements are needed to fully control variants and future pandemics.
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  • This text indicates a correction has been made to the scholarly article identified by the DOI 10.1093/ve/veab077.
  • It implies that there was an error or necessary update in the previously published work.
  • The correction is important for ensuring the integrity and accuracy of the research findings presented in that article.
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The aim of this study was conducted to validate the physicochemical properties of a total of 362 chemicals [305 skin sensitizers (212 in the previous study + 93 additional new chemicals), 57 non-skin sensitizers (38 in the previous study + 19 additional new chemicals)] for skin sensitization risk assessment using quantitative structure-activity relationship (QSAR)/quantitative structure-property relationship (QSPR) approaches. The average melting point (MP), surface tension (ST), and density (DS) of the 305 skin sensitizers and 57 non-sensitizers were used to determine the cutoff values distinguishing positive and negative sensitization, and correlation coefficients were employed to derive effective 3-fold concentration (EC3 (%)) values. QSAR models were also utilized to assess skin sensitization.

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Sucrose, hexoses, and raffinose play key roles in the plant metabolism. Sucrose and raffinose, produced by photosynthesis, are translocated from leaves to flowers, developing seeds and roots. Translocation occurs in the sieve elements or sieve tubes of angiosperms.

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