Controlled Disassembly of Elemental Sulfur: An Approach to the Precise Synthesis of Polydisulfides.

The usage of elemental sulfur (S ) for constructing sulfur-containing polymers is of great significance in terms of sulfur resource utilization or fabrication of high-performance polymers. Currently, the random disassembly of S hinders its direct use in the precise synthesis of sulfur-containing polymers. Herein, we provide an effective strategy for controlling the dismantlement of S to synthesize polydisulfides, a promising category of dynamic bonds containing polymers.

Triptolide inhibits viability and induces apoptosis in liver cancer cells through activation of the tumor suppressor gene p53.

The present study investigated the effect of triptolide on viability and apoptosis along with underlying mechanism in liver cancer cells. CCK-8 assay showed that triptolide treatment for 48 h significantly reduced the viability of HepG2 and QSG7701 cells at 50 µM concentration. Annexin V-FITC and propidium iodide staining showed that triptolide treatment of HepG2 cells at 50 µM concentrations induced apoptosis in 56.

Intestinal bacterium-derived cyp27a1 prevents colon cancer cell apoptosis.

The pathogenesis of metastasis of colon cancer (Cca) is to be further investigated. The dysfunction of apoptotic mechanism plays a role in the cancer cell over growth. This study tests a hypothesis by which intestinal bacterium-derived cyp27a1 prevents apoptosis in colon cancer cells.