1.7 µm figure-9 Tm-doped ultrafast fiber laser.

The evolution of multiphoton microscopy is critically dependent on the development of ultrafast laser technologies. The ultrashort pulse laser source at 1.7 µm waveband is attractive for in-depth three-photon imaging owing to the reduced scattering and absorption effects in biological tissues.

Pulsating dynamics in a pure-quartic soliton fiber laser.

We numerically investigate the pulsating dynamics of pure-quartic solitons (PQSs) in a passively mode-locked fiber laser. The bifurcation diagrams show that the PQS can alternate between the stable single soliton and pulsating regimes multiple times before transiting into the chaotic state. This multi-alternation behavior can be attributed to energy redistribution across the central part and the oscillating tails of the PQS, which is caused by an imperfect counterbalance between self-phase modulation (SPM)-induced and fourth-order dispersion (FOD)-induced phase shifts.

1.7 µm Tm-fiber chirped pulse amplification system with dissipative soliton seed laser.

We report on a 1.7 µm Tm-fiber chirped pulse amplification (CPA) system by virtue of a broadband dissipative soliton seed laser. The seed oscillator delivers the dissipative soliton with 10 dB spectral bandwidth of 23 nm and an average power of 4 mW.

Mutually induced soliton polarization instability in a bidirectional ultrafast fiber laser.

The bidirectional ultrafast fiber laser is a promising light source for dual-comb applications. The counter-propagating geometry could lead to soliton interaction through gain sharing, as well as the possible outcome of polarization instability. However, the polarization dynamics hidden behind the soliton interaction process in bidirectional fiber lasers were rarely investigated.

Prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy.

The purpose of this study was to investigate whether baseline neutrophil to lymphocyte ratio (NLR) was an independent predictor for early symptomatic intracranial hemorrhage (sICH), poor functional outcome and mortality at 3 months after reperfusion therapy in acute ischemic stroke (AIS) patients. Using PubMed and EMBASE, we searched for literature published before January 19th, 2019. Two reviewers independently confirmed each study's eligibility, assessed risk of bias, and extracted data.

Molecular mechanisms of heavy metals resistance of Stenotrophomonas rhizophila JC1 by whole genome sequencing.

In this study, a higher metal ions-resistant bacterium, Stenotrophomonas rhizophila JC1 was isolated from contaminated soil in Jinchang city, Gansu Province, China. The Pb (120 mg/L) and Cu (80 mg/L) removal rate of the strain reached at 76.9% and 83.

Targeting NLRP3 inflammasome improved the neurogenesis and post-stroke cognition in a mouse model of photothrombotic stroke.

Post-stroke cognitive impairment (PSCI) severely affects the quality of a survivor's life, but its neurophysiological basis remains unknown. Neuroinflammation has been considered as an important contributor to PSCI, which could be induced or exacerbated by system inflammation. NACHT-LRR- and pyrin-domain-containing protein 3 (NLRP3) inflammasome is the most widely studied in the initiation of inflammation.

[Effect of Carfilzomib on Proliferation and Apoptosis of Mantle Cell Lymphoma Cells].

Objective: To investigate the effect of Carfilzomib on mantle cell lymphoma (MCL), and to compare with effect of Bortezomib.

Methods: The Jeko-1 cells and primary MCL cells were treated with Carfilzomib for 24, 48 and 72 h, then the inhibitory rate was detected using CCK-8. Lymphocytes derived from healthy volunteer were served as cell controls.

Clinical and pathological analysis of solitary fibrous tumors with portal vein widening: A case report.

Rationale: Solitary fibrous tumors (SFTs) are rare soft-tissue tumors characterized with spindle-cell, which occur more common in the chest and rarely seen in the abdomen. So far as we knew, SFTs accompanied with venopathy of portal vein has rarely been reported.

Patient Concerns: A 36-year-old male presented with left-sided abdominal mass and portal vein expansion on ultrasound.

Genetic variants on chromosome 9p21 confer risks of cerebral infarction in the Chinese population: a meta-analysis.

Ischemic stroke (IS) is the leading cause of disability. Researchers have demonstrated that IS is more a multifactorial disorder than a single-factor disease. At present, no consistent conclusions have been reached on susceptibility loci for IS on chromosome 9p21.

Tre2 (USP6NL) promotes colorectal cancer cell proliferation via Wnt/β-catenin pathway.

Background: Most colorectal cancer (CRC) patients are diagnosed at an advanced or metastatic stage with poor prognosis. Ubiquitin-specific protease 6 N-terminal-like protein (USP6NL) with high expression in CRC tissues regulates CRC cell proliferation via Wnt/β-catenin pathway. We hypothesized that USP6NL impacts CRC growth and inhibition of USP6NL may be a novel treatment strategy to improve CRC therapy.

G-protein-signaling modulator 2 expression and role in a CD133 pancreatic cancer stem cell subset.

Background: To investigate the expression and role of G-protein-signaling modulator 2 (GPSM2) in a CD133 pancreatic stem cell subset.

Materials And Methods: Pancreatic cancer stem cells (PCSCs) from the cell line PANC-1 were sorted into CD133 and CD133 subsets by flow cytometry. The tumorigenic potential of the subsets was assessed by subcutaneous tumor formation experiments in nude mice.

PLK1 as a potential prognostic marker of gastric cancer through MEK-ERK pathway on PDTX models.

Background: PLK1 has been identified as having a great effect on cell division and maintaining genomic stability in mitosis, spindle assembly, and DNA damage response by current studies.

Materials And Methods: We assessed PLK1 expression in cervical cancer tissues and cells. We have also evaluated the effects of PLK1 on gastric cancer cell proliferation, migration, and apoptosis both in vitro and in vivo.

IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis .

Aim: To investigate the role of interferon regulatory factor 5 (IRF5) in reversing polarization of lung macrophages during severe acute pancreatitis (SAP) .

Methods: A mouse SAP model was established by intraperitoneal (ip) injections of 20 μg/kg body weight caerulein. Pathological changes in the lung were observed by hematoxylin and eosin staining.

Protective effects of edaravone against cobalt chloride-induced apoptosis in PC12 cells.

Objective: To investigate the neuroprotective effects of edaravone (Eda) on cobalt chloride (CoCl2)-induced oxidative stress and apoptosis in cultured PC12 cells as well as the underlying mechanisms.

Methods: PC12 cells impaired by CoCl2 were used as the cell model of hypoxia. MTT (methyl thiazolyl tetrazolium) was used to assay the viability of the PC12 cells exposed to Eda with gradient concentrations; Hochest 33258 stain assay was used to analyze the apoptosis ratio of the PC12 cells; Bcl-2 and Bax protein levels in PC12 cells were examined by western blotting.

Genes encoding the Vibrio harveyi haemolysin (VHH)/thermolabile haemolysin (TLH) are widespread in vibrios.

V. harveyi VHH haemolysin, which shows high homology to the TLH haemolysin (the identities of their deduced amino acid sequences are up to 85.6%), is a putative virulence factor to marine cultured fish.

Isolation of Photobacterium damselae subsp. piscicida from diseased tongue sole (Cynoglossus semilaevis Gunther) in China.

During the summer of 2006, an epizootic occurred among cultured tongue sole (Cynoglossus semilaevis Gunther) in a fish farm in Qingdao, China. The diseased tongue sole exhibited haemorrhaging of the basal fin, yellowed kidney and ulceration of the body surface. A Gram-negative,rod shaped bacterium (designated strain WY06) was isolated from the gall bladder of diseased fish.

[In vitro induction and expansion of dendritic cells from rat bone marrow and their characterization].

Aim: To induce and expand dendritic cells (DC) from rat bone marrow in vitro and identify their biological characterization.

Methods: The rat bone marrow cells were collected and cultured for 48 hours and the floating cells were removed. Then IL-4 and GM-CSF were added into the fresh medium.