Publications by authors named "Ji-Su Yang"

Background: Women with schizophrenia frequently discontinue antipsychotic medications during pregnancy. However, evidence on the risk of postpartum relapse associated with antipsychotic use during pregnancy is lacking.

Aims: To investigate the within-individual association between antipsychotic continuation during pregnancy and postpartum relapse in women with schizophrenia.

View Article and Find Full Text PDF
Article Synopsis
  • Schizophrenia is associated with an increased risk of breast cancer compared to both the general population and women with other psychiatric conditions.
  • Women with schizophrenia show a 1.26 times higher hazard rate for breast cancer than the general public and a 1.17 times higher rate compared to other psychiatric patients.
  • The risk is particularly elevated in women with schizophrenia who have been on antipsychotic medication for a year or more.
View Article and Find Full Text PDF

Background: Previous research has shown that the use of renin-angiotensin system (RAS) blockers is linked to a lower prevalence of posttraumatic stress disorder (PTSD), but longitudinal studies are scarce. We aimed to estimate the association between the use of RAS blockers and the risk of PTSD among individuals taking antihypertensive medications.

Methods: This longitudinal study included participants aged 40-69 from the UK Biobank.

View Article and Find Full Text PDF
Article Synopsis
  • Ubiquitination modifies proteins with ubiquitin to regulate their degradation or functions, while deubiquitinating enzymes (DUBs) remove ubiquitin, influencing these processes.
  • USP2a, a DUB, is highlighted as a promising cancer therapy target, but effective inhibitors have been scarce.
  • The study focused on optimizing a USP2a inhibitor, ML364, resulting in compound 8v, which showed lower toxicity, reduced USP2a targets, decreased cancer cell growth, and selective inhibition of USP2a compared to other related proteins.
View Article and Find Full Text PDF

Background: This study estimated the association between pre-pandemic social network properties and symptoms of posttraumatic stress during the coronavirus disease 2019 (COVID-19) pandemic in South Korea.

Methods: We conducted four online mental health surveys during COVID-19 (from March 14, 2020, to December 11, 2021) among individuals enrolled in a community-based cohort study (previously recruited from 2013 to 2018). Among 4060 people interviewed at the pre-pandemic baseline, 2652 individuals (men = 951, women = 1701) who responded to at least one of the four surveys conducted were included.

View Article and Find Full Text PDF

Identification of soft rot disease in napa cabbage, an essential ingredient of kimchi, is challenging at the industrial scale. Therefore, nondestructive imaging techniques are necessary. Here, we investigated the potential of hyperspectral imaging (HSI) processing in the near-infrared region (900-1700 nm) for classifying napa cabbage quality using nondestructive measurements.

View Article and Find Full Text PDF

Objectives: The aim of this study was to explore factors affecting attitudes toward coronavirus disease 2019 (COVID-19) vaccination, including socio-demographic characteristics and mental health status during the pandemic.

Methods: This study analyzed responses from 1,768 participants who were originally included in a community cohort study and responded to 3 online surveys related to COVID-19 (March 2020 to March 2021). The k-means method was used to cluster trust in and intention to receive COVID-19 vaccination.

View Article and Find Full Text PDF

Background: This study aimed to investigate how social networks are associated with cognitive function in the middle-aged and elderly Korean population.

Methods: A total of 7,704 individuals over the age of 50 were included from the baseline recruitment of the Cardiovascular and Metabolic Diseases Etiology Research Center cohort from the years 2013 to 2018. Egocentric social network characteristics including network size, intimacy, and frequency of face-to-face meetings were measured as exposures, and the Korean version of Mini-Mental State Examination (K-MMSE) score was measured to reflect general cognitive function as an outcome.

View Article and Find Full Text PDF

Processes in the food industry that use large amounts of water have been an important cause of waterborne disease outbreaks, as they expose individuals to risks for waterborne disease transmission. Developing technologies to ensure the hygiene and safety of food-processing steps is an urgent concern from an economic perspective. Furthermore, economic benefits can be derived if the processed water can be reused under microbiologically safe conditions.

View Article and Find Full Text PDF

Unlabelled: This study aimed to evaluate the virucidal effect and potential use as a disinfectant of undiluted and diluted slightly acidic electrolyzed water (SAEW) on human noroviruses (HuNoVs) using the in vitro suspension test and in food test. The oxidization reduction potential of SAEW gradually decreased with the increase in distilled water volume. Moreover, as the volume of distilled water and the dilution ratio increased, the available chlorine concentration of the samples significantly decreased from 31.

View Article and Find Full Text PDF

Fatty acid synthase (FASN) plays an important role in cancer development, providing excess lipid sources for cancer growth by participating in de novo lipogenesis. Although several inhibitors of FASN have been developed, there are many limitations to using FASN inhibitors alone as cancer therapeutics. We therefore attempted to effectively inhibit cancer cell growth by using a FASN inhibitor in combination with an inhibitor of a deubiquitinating enzyme USP14, which is known to maintain FASN protein levels in hepatocytes.

View Article and Find Full Text PDF

Objective: We aimed to investigate the mental health impact of COVID-19 on a demographically well-characterized population cohort by gender and previous depression status.

Methods: Among people who participated in a community cohort study between 2013 and 2018 with previous depression measurement, a total of 1928 people without quarantine experience (680 men and 1249 women) were included after responding to an online survey in March 2020. In the 2020 survey, people were queried about daily needs supply, social support, risk perception, change during the COVID-19 pandemic, as well as mental health indices measuring loneliness, anxiety symptoms, post-traumatic stress disorder (PTSD), and depression.

View Article and Find Full Text PDF

Background: The present study aimed to investigate the association between resilience and cognitive function of middle-aged Koreans in a longitudinal setting.

Methods: We utilized the baseline and 5-year follow-up data from the Cardiovascular and Metabolic Diseases Etiology Research Center study. The final number of participants included in the analysis was 397 (108 men, 289 women, mean age 55.

View Article and Find Full Text PDF

Background: There are several ways to determine psychological resilience. However, the correlation between each measurement is not clear. We explored associations of baseline relative "resilience" and risk with later self-reported trait resilience and other biological/mental health indices.

View Article and Find Full Text PDF

Kimchi is a traditional Korean fermented vegetable, which is also widely consumed in Japan and China. However, little is known about the kimchi proteome. In this study, Korean and Chinese kimchi proteomes were evaluated by shotgun proteomics.

View Article and Find Full Text PDF

Long-term storage of chili pepper powder results in physicochemical and microbiological changes that decrease its commercial value; these changes occur owing to fungal growth and production of off-flavor compounds. Herein, long-term-stored chili pepper powder (LSCPP) and fresh chili pepper powder (FCPP) were analyzed using internal transcribed spacer sequencing and volatile organic compound fingerprinting by headspace capillary-gas chromatography-ion mobility spectrometry. Fungal analysis detected only Xeromyces bisporus with high accuracy in all the analyzed LSCPP samples.

View Article and Find Full Text PDF

Identifying the extracellular metabolites of microorganisms in fresh vegetables is industrially useful for assessing the quality of processed foods. subsp. (PCC) is a plant pathogenic bacterium that causes soft rot disease in cabbages.

View Article and Find Full Text PDF

Cabbage kimchi, a popular side dish in Korean cuisine, produces several fermentation by-products (FBPs). Kimchi is praised for its flavor, taste, and texture when suitably fermented at 0.7% to 0.

View Article and Find Full Text PDF

Quinolizidine alkaloids (QAs) are toxic secondary metabolites of plants. This study reports the simultaneous quantification of five alkaloids from L. and its processed foods by ultraperformance liquid chromatography with electrospray ionization mass spectrometric detection.

View Article and Find Full Text PDF
Article Synopsis
  • Capsaicinoids in red pepper powder have anti-bacterial properties, and this study explored their impact on kimchi fermentation using various concentrations ranging from no capsaicinoids to extremely high amounts.
  • The research found that kimchi with red pepper powder had higher acidity and organic acid levels compared to control kimchi, likely due to increased counts of lactic acid bacteria (LAB).
  • The study suggests that the physicochemical properties and microbial community of kimchi are affected by the capsaicinoid content, but further research is needed to determine the optimal amount of red pepper powder for standardized kimchi production.
View Article and Find Full Text PDF

Background: Kimchi, a Korean food, is now produced and consumed in many other countries. In this study, the macro, trace, and toxic element content in varieties of kimchi from Korea and China was evaluated. A health-risk assessment, involving the calculation of estimated dietary intake values, was undertaken.

View Article and Find Full Text PDF

Background/objectives: Oxidative stress is a major effector of various diseases; accordingly, antioxidants are frequently ingested in order to prevent or alleviate disease symptoms. Kimchi contains various natural antioxidants, and it is known that the functional activity varies depending on the ingredients and fermentation state. Black raspberries (BR) contain various bioactive compounds with antioxidant effects.

View Article and Find Full Text PDF

The widespread applications of graphene family nanomaterials (GFNs) raised the considerable concern over human health and environment. The cyto-genotoxic potentiality of GFNs has attracted much more attention, albeit the potential effects on the cellular epigenome remain largely unknown. The effects of GFNs on cellular genome were evaluated with single and double stranded DNA damage and DNA repair gene expressions while the effects on epigenome was accomplished by addressing the global DNA methylation and expression of DNA methylation machineries at non-cytotoxic to moderately cytotoxic doses in in vitro system.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionc3rnadr83l62t93feu70h51jv8hg7ptp): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once