Publications by authors named "Ji-Rui Wen"
Article Synopsis
- Pelvic floor disorders (PFDs), common among women, negatively impact quality of life and often require surgical intervention, but nearly 30% of patients need additional surgeries due to complications and recurring issues.
- Stem cells show potential as a new treatment option for PFD because they can differentiate into various pelvic floor tissue types, aiding in regeneration, elasticity, and reducing inflammation.
- Despite promising results from studies using autologous stem cells, complications like bladder stones and infections highlight the need for more research into stem cell therapies and alternative methods, aiming for safer and more effective PFD treatments in the future.
[Screening of the Optimum Medium for Rat Mesenchymal Stem Cells].
Sichuan Da Xue Xue Bao Yi Xue Ban
December 2019
Objective: To investigate the effect of three different cell culture mediums, DMEM-LG, α-MEM and DMEM/F12, on the growth of rat bone marrow mesenchymal stem cells (BMSCs) , and so that to screen out the most suitable medium for culturing the rat BMSCs.
Methods: BMSCS were isolated from the femur and tibia of SD rats by whole bone marrow differential adherence method. The isolated cells were then cultured with three culture mediums, DMEM-LG, α-MEM and DMEM/F12.
[IL-8 Induces Epithelial-to-mesenchymal Transition of Ovarian Carcinoma Cells: a Preliminary Study].
Sichuan Da Xue Xue Bao Yi Xue Ban
May 2018
Objective: To explore the effect of IL-8 on the epithelial-to-mesenchymal transition (EMT) in ovarian cancer,which will provide experimental basis for revealing related molecular mechanism in malignant metastasis of ovarian cancer.
Methods: The migration of ovarian cancer cell line SKOV3 cells was explored with Real time label free cell analysis (RTCA) after treatment with recombinant human IL-8.SKOV3 cells were co-cultured with IL-8 for 48 h,proteins involved in EMT were investigated via Western blot to explore the effect of IL-8 on the activation of the EMT.