Publications by authors named "Ji-Min Lv"
Plant diseases caused by microbial pathogens pose a severe threat to global food security. Although genetic modifications can improve plant resistance; however, environmentally sustainable strategies are needed to manage plant diseases. Nano-enabled immunomodulation involves using engineered nanomaterials (ENMs) to modulate the innate immune system of plants and enhance their resilience against pathogens.
View Article and Find Full Text PDFThe integration between RNA-sequencing and micro-spectroscopic techniques has recently profiled the advanced transcriptomic discoveries on the cellular level. In the current study, by combining the sensation approach (including bio-molecules structural evaluation, high throughput next-generation sequencing (HT-NGS), and confocal Raman microscopy) the functionality on the single live cancer cells' ferroptosis and apoptosis signaling pathways is visualized. Our study reveals a hydrophobic tunnel by phycocyanin-isoprene molecule (PC-SIM) electrostatic charge within hepatoma cells (HepG2) that activates the ferritin light chain (FTL) and caspase-8 associate protein (CASP8AP2) ferroptosis responsible genes.
View Article and Find Full Text PDFThe poor biostability and bioavailability of proanthocyanidins limit their application. In this study, it was hypothesized that encapsulation in lecithin-based nanoliposomes using ultrasonic technology improves the above properties. Based on preliminary experiments, the effects of lecithin mass ratio (1-9%, wt.
View Article and Find Full Text PDFArticle Synopsis
- Proanthocyanidins (PAs), found in kiwi leaves, are identified as natural antioxidants, but their specific action pathways were not well-studied before this research.
- The study demonstrated that purified kiwi leaf PAs (PKLPs) effectively lower oxidative damage in Caco-2 cells caused by hydrogen peroxide (H2O2), reducing reactive oxygen species (ROS) and malondialdehyde levels while increasing antioxidant enzyme expression.
- This research highlights the role of PKLPs in activating the Nrf2-ARE signaling pathway, suggesting their potential for applications in promoting cell protection against oxidative stress.
Article Synopsis
- Ultrasound technology (US) is emerging as a key method for extracting proanthocyanidins (PAs) from kiwifruit leaves, enhancing the study of bioactive compounds.
- The study identified optimal conditions for PA extraction using US, which include 40% amplitude, a solvent to solid ratio of 30 mL/g dry weight, at 70°C for 15 minutes.
- Findings showed that the purified kiwifruit leaves PAs (PKLPs) exhibit significant antioxidant activities, suggesting potential applications in drug discovery and food science.