Publications by authors named "Ji-Mim Fan"
Article Synopsis
- Intermittent hypoxia and sleep fragmentation in obstructive sleep apnea-hypopnea syndrome (OSAHS) may disrupt gut microbiota, which could in turn affect brain function through the microbiota-gut-brain axis.
- The study involved a survey of gut microbiome composition in OSAHS patients, identifying three enterotypes: Bacteroides, Ruminococcus, and Prevotella, along with analyzing their sleep parameters and inflammatory markers.
- Findings suggest that the Prevotella enterotype is linked to greater sleep disruptions and higher apnea-hypopnea index (AHI) scores, hinting at an interaction between gut microbiota and sleep disturbances in OSAHS.
Gut microbiota alterations manifest as intermittent hypoxia and fragmented sleep, thereby mimicking obstructive sleep apnea-hypopnea syndrome (OSAHS). Here, we sought to perform the first direct survey of gut microbial dysbiosis over a range of apnea-hypopnea indices (AHI) among patients with OSAHS. We obtained fecal samples from 93 patients with OSAHS [5 < AHI ≤ 15 (=40), 15 < AHI ≤ 30 (=23), and AHI ≥ 30 (=30)] and 20 controls (AHI ≤ 5) and determined the microbiome composition via 16S rRNA pyrosequencing and bioinformatics analysis of variable regions 3-4.
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