Chinese herbal medicine for carriers of the hepatitis B virus: an updated systematic review and meta-analysis.

More than a third of the world's population is infected with the hepatitis B virus (HBV) and 5% are thought to be HBV carriers, putting them at risk of developing serious liver diseases. The treatment of liver diseases with Chinese herbal medicines (CHM) dates back 2,500 years and the aim of this analysis was to evaluate the efficacy and safety of CHM for HBV carriers compared to Western medicine (WM) or placebo and to summarize the most commonly used herbs. Several databases, such as Pubmed, Embase and the Chinese database CNKI, were used to evaluate randomized, controlled trials (RCTs) focused on CHM treatment for HBV carriers up to 2013.

Association between Mannose-binding lectin gene polymorphisms and hepatitis B virus infection: a meta-analysis.

Objective: The results of studies on the relation between Mannose-binding lectin gene (mbl2) polymorphism and HBV infection were contradictory and inconclusive. In order to shed a light on these inconsistent findings and to clarify the role of mbl2 polymorphisms in susceptibility or progression of chronic hepatitis B (CHB), a meta-analysis was performed.

Methods: PubMed and Embase were searched for available articles.

Lumbopelvic fixation for multiplanar sacral fractures with spinopelvic instability.

Sacral fractures with both transverse and bilateral vertical fracture components are by definition multiplanar fractures, and often present with spinopelvic instability and cauda equina deficits. The treatment is challenging. Between 2006 and 2009, we treated nine such patients at our trauma centre.

An investigation of oxidative DNA damage in pharmacy technicians exposed to antineoplastic drugs in two Chinese hospitals using the urinary 8-OHdG assay.

Objective: To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.

Methods: Urinary 8-OHdG served as a biomarker. 5-Fluorouracil (5-FU) concentrations in air, masks and gloves were determined.

[Inhibition of hepatitis C virus replication by small interfering RNA in cells infected by HCV].

Objective: To investigate the inhibitive effects of small interfering RNA (siRNA) on hepatitis C virus (HCV) replication in cells infected by HCV in vitro.

Methods: The HCV RNA transcripts prepared by pFL-JC1 were transfected into Huh-7.5.

Comparison of isocentric C-arm 3-dimensional navigation and conventional fluoroscopy for C1 lateral mass and C2 pedicle screw placement for atlantoaxial instability.

Study Design: A retrospective study.

Objective: The aim of the study was to compare the precision of C1 lateral mass and C2 pedicle (C1LM-C2P) screw fixation for atlantoaxial instability using the isocentric C-arm 3-dimensional (Iso-C 3D) navigation versus conventional fluoroscopy.

Summary Of Background Data: The Iso-C 3D navigation has been widely used in spinal surgeries in recent years.

[Analysis of new pneumoconiosis cases during 2006-2009 in Zhejiang province].

Objective: To analyze the characteristics of pneumoconiosis cases in Zhejiang province and to provide the evidence for pneumoconiosis control and prevention measures in Zhejiang province.

Methods: The data of new pneumoconiosis cases were from national surveillance system of occupational disease in Zhejiang province during 2006-2009, and were analyzed for distribution, age, exposure duration, pneumoconiosis phases and enterprise types.

Results: During 2006-2009, 819 new pneumoconiosis cases (173, 157, 209 and 280 cases, respectively) were reported, 86.

Inhibition of hepatitis C virus replication by single and dual small interfering RNA using an HCV-infected cell model.

Dual siRNA against different regions of gene in hepatitis C virus (HCV) synergistically inhibited replication of HCV RNA. An HCV-infected cell model was established, and HCV RNA and core protein were detected by RT-PCR and Western blot, respectively. Four HCV-specific siRNAs (siCore, siNS3, siNS4B, siNS5B) were designed and transfected into HCV-infected Huh7.

[Genotoxicity of organic bentonite particles in vitro].

Objective: To study the genotoxicity induced by organic bentonite particles in vitro.

Methods: Human B lymphoblast cells (HMy2.CIR) were exposed to organic bentonite particles at the doses of 0, 1.

[Investigation on occupational exposure to 5-fluorouracil in pharmacy intravenous admixture service of a hospital].

Objective: To investigate the level of occupational exposure to 5-fluorouracil (5-Fu) in the pharmacy intravenous admixture service (PIVAS) of a hospital, and identify the sources of 5-Fu contamination.

Methods: The 5-Fu concentrations in air, on the surface of different areas in PIVAS and personal protective equipments were detected using UV-vis spectrophotometry.

Results: The 5-Fu in air could not be detected.

[Comparative study of cytotoxicity induced by two kinds of bentonite particles in vitro].

Objective: To study comparatively the cytotoxicity induced by acid bentonite and organic bentonite.

Methods: The cytotoxicity of two kinds of bentonite was detected using CCK8 assay, neutral red uptake (NRU) assay, lactate dehydrogenase (LDH) leakage assay, apoptosis assay and hemolysis assay. In hemolysis assay human erythrocytes served as target cells and were exposed to the two kinds of bentonite at the doses of 0, 0.

[Cyto-genotoxicity induced by cigarette smoke condensates in human peripheral blood lymphocytes in vitro].

Objective: To investigate the cyto-genotoxicity of cigarette smoke condensates (CSCs) in human peripheral blood lymphocytes with different assays in vitro.

Methods: Human lymphocytes were exposed to particle matter of cigarette smoke combined with or without S9 mixtures at doses of 25, 50, 75, 100 and 125 microg/ml for 3 h. The cytotoxicity induced by CSCs was detected by CCK-8 assay.

Response of lymphocytes to radiation in untreated breast cancer patients as detected with three different genetic assays.

Objective: To detect the response of lymphocytes to radiation in untreated breast cancer patients with three different genetic assays.

Methods: Blood samples were collected from 25 untreated patients and 25 controls. Each blood sample was divided into two parts: one was irradiated by 3-Gy X-ray (irradiated sample), the other was not irradiated (non-irradiated sample).

[Mutagenic, carcinogenic and teratogenic effects induced by radiofrequency electromagnetic field of mobile phone].

The extensive use of mobile phones causes increasing public concern on health effects of exposure to radiofrequency (RF) electromagnetic fields. Conflicting results are found in publications on the mutagenic, carcinogenic and teratogenic effects of RF electromagnetic fields. The overwhelming findings do not support the assumption that RF exposure may induce mutagenic, carcinogenic or teratogenic effects.

[Blocking 1800 MHz mobile phone radiation-induced reactive oxygen species production and DNA damage in lens epithelial cells by noise magnetic fields].

Objective: To investigate whether the exposure to the electromagnetic noise can block reactive oxygen species (ROS) production and DNA damage of lens epithelial cells induced by 1800 MHz mobile phone radiation.

Methods: The DCFH-DA method and comet assay were used respectively to detect the intracellular ROS and DNA damage of cultured human lens epithelial cells induced by 4 W/kg 1800 MHz mobile phone radiation or/and 2 muT electromagnetic noise for 24 h intermittently.

Result: 1800 MHz mobile phone radiation at 4 W/kg for 24 h increased intracellular ROS and DNA damage significantly (P<0.

[Influence of 1.8 GHz microwave on DNA damage induced by ultraviolet C ray].

Objective: To study whether 1.8 GHz microwaves (MW) (SAR, 3 W/kg) exposure can influence DNA damage induced by ultraviolet ray (UV).

Methods: The lymphocytes were obtained from three young healthy donors.

[DNA damage and repair induced by acute exposure of microwave from mobile phone on cultured human lens epithelial cells].

Objective: To investigate the effects of acute exposure of low-power 217 Hz modulated 1. 8 GHz microwave radiation on the DNA damage of human lens epithelial cells (hLECs) and repair.

Methods: Cultured hLECs were exposed to 217 Hz modulated 1.

[Effect of acute exposure to microwave from mobile phone on DNA damage and repair of cultured human lens epithelial cells in vitro].

Objective: To investigate the DNA damage of human lens epithelial cells (LECs) caused by acute exposure to low-power 217 Hz modulated 1.8 GHz microwave radiation and DNA repair.

Methods: Cultured LECs were exposed to 217 Hz modulated 1.

[Investigating genetic damage of workers occupationally exposed to methotrexate].

Objective: To study genetic damage of workers alone occupationally exposed to methotrexate (MTX) with three end-points.

Methods: The blood samples from 21 workers exposed to MTX and 21 controls were detected with micronucleus test, comet assay, hprt gene mutation test and TCR gene mutation test.

Results: The mean micronuclei rate (MNR) and mean micronucleated cells rate (MCR) in 21 workers were 10.

Assessment of human DNA repair (NER) capacity with DNA repair rate (DRR) by comet assay.

Objective: Alkaline comet assay was used to evaluate DNA repair (nucleotide excision repair, NER) capacity of human fresh lymphocytes from 12 young healthy non-smokers (6 males and 6 females).

Methods: Lymphocytes were exposed to UV-C (254 nm) at the dose rate of 1.5 J/m2/sec.

[Detecting DNA repair capacity of human lymphocytes exposed to ultraviolet C with comet assay].

Objective: To assess DNA repair capacity of human lymphocytes with comet assay.

Methods: Fresh lymphocytes form twelve 26-year old donors (6 males, 6 females) were exposed to ultraviolet C (UVC, 254 nm) at the dose rate of 1.5 J/m(2).