Publications by authors named "Ji-Li Lu"
Ann Transl Med
February 2022
Article Synopsis
- Osteoarthritis (OA) is a prevalent condition in older adults, but the molecular mechanisms behind its development and progression are still unclear; this study explored these mechanisms using a competing endogenous RNA (ceRNA) network approach.
- Researchers analyzed various mRNA, miRNA, and lncRNA datasets to identify differentially expressed genes (DEGs) and constructed a ceRNA network to explore their biological functions through enrichment analyses, as well as assessing immune cell presence in OA versus healthy samples.
- Key findings revealed significant players like hsa-mir-425-3p and dual specificity phosphatase 1 in the ceRNA network, highlighting their roles in important biological processes linked to immune responses and OA progression, suggesting potential targets for further
