Publications by authors named "Ji-Li Cui"
[Oral candida species distribution in patients receiving radiotherapy for head and neck cancer].
Shanghai Kou Qiang Yi Xue
October 2014
Purpose: To investigate the distribution of oral candida species in head and neck cancer (HNC) patients treated with radiation therapy, and provide the basis for planning of clinical preventive measures.
Methods: Saliva was sampled from 60 HNC patients before, during and after radiation. Concomitantly, 60 healthy individuals whose age and sex matched that of the patient group were selected as control group.
We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.
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- The study investigates the role of human papillomavirus (HPV) in esophageal cancer, comparing it to its well-established role in cervical cancer, analyzing 145 esophageal and 143 cervical tissue samples from a high-incidence area in Northern China.
- Researchers found that high-risk HPV types were present in over 90% of the HPV-positive lesions, with a significant increase in prevalence as both esophageal and cervical lesions progressed from normal to cancerous.
- High-risk HPV infection significantly elevated the risk of developing dysplasia and invasive cancer for both esophagus (4-fold increase) and cervix (12 to 20-fold increase), with HPV 16 being the most common subtype detected in both tissue types.
Oral lichen planus (OLP) is a T cell-mediated autoimmune disease of oral mucosa, in which T helper 1 (Th1) cells are greatly involved. Chemokine CCL5 is required for T cells infiltration and activation. CCR5, one of its receptors, specifically expressed on Th1 cells among CD4(+) T cells, can be up-regulated by Th1 cytokines like interleukin2 (IL-2) and interferon-gamma (IFN-γ), and down-regulated by Th2 cytokines like IL-4.
View Article and Find Full Text PDFGenome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at 2q33 with P< 5 × 10(-8), and the strongest signal was rs13016963, with a combined odds ratio (95% confidence interval) of 1.
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