A Single Center Experience of Pulmonary Arterial Hypertension Management in Korea: A 25-Year Comparative Analysis Following the Introduction of Targeted Therapy.

Background And Objectives: The transformation of pulmonary arterial hypertension (PAH) treatment in Korea, ushered by targeted therapy's advent, prompted our analysis of baseline attributes, treatment trends, and survival shifts within our single-center registry.

Methods: We examined 230 patients (72.6% female, mean age 40.

Intravascular Imaging-Guided Optimization of Complex Percutaneous Coronary Intervention by Sex: A Subgroup Analysis of the RENOVATE-COMPLEX-PCI Trial.

Importance: There have been heterogeneous results related to sex differences in prognosis after percutaneous coronary artery intervention (PCI) for complex coronary artery lesions.

Objective: To evaluate potential differences in outcomes with intravascular imaging-guided PCI of complex coronary artery lesions between women and men.

Design, Setting, And Participants: This prespecified substudy evaluates the interaction of sex in the investigator-initiated, open-label, multicenter RENOVATE-COMPLEX-PCI randomized clinical trial, which demonstrated the superiority of intravascular imaging-guided PCI compared with angiography-guided PCI in patients with complex coronary artery lesions.

The Relationship between Depression Severity and Prefrontal Hemodynamic Changes in Adolescents with Major Depression Disorder: A Functional Near-infrared Spectroscopy Study.

Objective: : Numerous studies have identified hemodynamic changes in adults with major depressive disorder (MDD) by using functional near-infrared spectroscopy (fNIRS). However, studies on adolescents with MDD are limited. As adolescence is a stage of rapid brain development, differences may occur depending on age.

Selective Lithium Adsorption of Silicon Oxide Coated Lithium Aluminum Layered Double Hydroxide Nanocrystals and Their Regeneration.

Silicon oxide-coated lithium aluminum layered double hydroxide (Li Al -LDH@SiO ) nanocrystals (NCs) are investigated to selectively separate lithium cations in aqueous lithium resources. We directly synthesized Li Al -LDH NC arrays by oxidation of aluminum foil substrate under a urea and lithium solution. Various lithium salts, including Cl , CO , NO , and SO , were applied in aqueous solution to confirm the anion effect on the captured and released lithium quantity of the Li Al -LDH NCs.

Formation and Encapsulation of All-Inorganic Lead Halide Perovskites at Room Temperature in Metal-Organic Frameworks.

Improving the stability and tuning the optical properties of semiconducting perovskites are vital for their applications in advanced optoelectronic devices. We present a facile synthetic method for hybrid composites of perovskites and metal-organic frameworks (MOFs). A simple two-step solution-based method without organic surfactants was employed to make all-inorganic lead-halide perovskites (CsPbX; X = Cl, Br, I, or mixed halide compositions) form directly in the pores of MIL-101 MOF.

Core-Shell Structured Cobalt Sulfide/Cobalt Aluminum Hydroxide Nanosheet Arrays for Pseudocapacitor Application.

The direct synthesis of nanostructured electrode materials on three-dimensional substrates is important for their practical application in electrochemical cells without requiring the use of organic additives or binders. In this study, we present a simple two-step process to synthesize a stable core-shell structured cobalt sulfide/cobalt aluminum hydroxide nanosheet (LDH-S) for pseudocapacitor electrode application. The cobalt aluminum layered double hydroxide (CoAl-LDH) nanoplates were synthesized in basic aqueous solution with a kinetically-controlled thickness.

Air-Stable Transparent Silver Iodide-Copper Iodide Heterojunction Diode.

Transparent AgI-CuI heterojunctions with high rectifying diode behavior were prepared via vapor-phase iodization of metal thin films on transparent conducting oxide substrates. At room temperature, Ag and Cu metal thin films were quickly transformed into the transparent and well-crystallized β-phase of AgI and the γ-phase of CuI, respectively. The AgI and CuI films exhibited n-type and p-type semiconductor properties, respectively, with wide band gaps.

Photoresponse of CsPbBr and CsPbBr Perovskite Single Crystals.

High-quality and millimeter-sized perovskite single crystals of CsPbBr and CsPbBr were prepared in organic solvents and studied for correlation between photocurrent generation and photoluminescence (PL) emission. The CsPbBr crystals, which have a 3D perovskite structure, showed a highly sensitive photoresponse and poor PL signal. In contrast, CsPbBr crystals, which have a 0D perovskite structure, exhibited more than 1 order of magnitude higher PL intensity than CsPbBr, which generated an ultralow photoresponse under illumination.

Structural, Electrical, and Optical Properties of ZnO Film Used as Buffer Layer for CIGS Thin-Film Solar Cell.

The CuIn(x)Ga(1-x)Se2 (CIGS) using the solution-based fabrication method is attractive for thin film solar cells because of its possibilities for large-area and low-cost production. ZnO films between transparent conductive oxide (TCO) and the CdS films can improve the performances of CIGS thin-film solar cells. In this study, we investigated the characteristics of ZnO film between TCO and CIGS layers in a solar cell (AZO/ZnO/CdS/CIGS/Mo), which were deposited at various thicknesses to investigate the role of the films in CIGS solar cells.

Nanostructured cobalt hydroxide thin films as high performance pseudocapacitor electrodes by graphene oxide wrapping.

We synthesized binder-free Co(OH)2 nanocrystals on nickel electrodes by the ammonia transfer method in an aqueous solution and kinetically-controlled their thickness and height to enhance the capacitance through the facile diffusion of electrolytes in the nanocrystals. As thinner Co(OH)2 films were developed, the specific capacitance increased up to 1260 F g(-1) at a current density of 10 A g(-1). A thin layer of graphene oxide (GO) was used to wrap the Co(OH)2 nanocrystals to create a pseudocapacitor with high specific capacitance and good cyclic stability.

Synthesis and Nanostructures of Metal Selenide Precursors for Cu(In,Ga)Se2 Thin-Film Solar Cells.

A nanoink solution-based process was developed as a low-costing method for the fabrication of Cu(In,Ga)Se2 (CIGSe) thin-film photovoltaic cells. The sonochemical synthesis of CIGSe nanocrystals of the nanoink through step-by-step mixing of the reactants was investigated. To achieve the ideal stoichiometry of Cu(In0.

Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder.

We tested for the association of HTR1A and 5-HTT genetic polymorphisms with treatment response to mirtazapine and evaluated the interactive effect between the polymorphisms in 283 patients with major depressive disorder. Korean subjects with diagnosis of major depressive disorder using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I disorders were recruited. Clinical symptoms were evaluated using the 17-item Hamilton Depression Rating (HAMD-17) Scale at baseline and after 1, 2, 4, 8, and 12 weeks of treatment with mirtazapine.

CuGaS2 hollow spheres from Ga-CuS core-shell nanoparticles.

A liquid gallium emulsion was prepared as a starting material using ultrasound treatment in ethylene glycol. Core-shell particles of Ga@CuS were successfully synthesized by deposition of a CuS layer on gallium droplets through sonochemical deposition of copper ions and thiourea in an alcohol media. The core and shell of Ga@CuS products were composed of amorphous gallium metal and covellite phase CuS, which transformed into chalcopyrite CuGaS2 hollow spheres after sulfurization at 450°C, which was the lowest crystallization temperature.

The Korean Medication Algorithm for Major Depressive Disorder (KMA-MDD): Report of the Korean Society of Depressive and Bipolar Disorders.

Objective. There are many differences in biological characteristics, clinical situations, and medical insurance systems with ethnic groups or countries. The Korean Society of Depressive and Bipolar Disorders decided to develop a Korean treatment algorithm for major depressive disorder.

Association between norepinephrine transporter gene polymorphism and major depression.

Noradrenergic and serotonergic abnormalities have long been implicated in patients with major depression. The novel selective norepinephrine reuptake inhibitor reboxetine has been shown to be at least as effective as imipramine, desipramine and fluoxetine in the treatment of major depression. It is suggested that the dysfunction of the norepinephrine transporter (NET) may be related to major depression.

Association between major depressive disorder and the -1438A/G polymorphism of the serotonin 2A receptor gene.

This study investigated the possible effect of the -1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (chi(2) = 10.78, d.

Serotonergic genes and personality traits in the Korean population.

Serotonergic genes have been implicated in mood disorders, alcoholism and certain personality traits. The goal of this study was to investigate the relationship between personality traits and several important genes in the serotonin system. The participants included 146 healthy adults with no history of psychiatric disorders or other physical illness during the last 6 months.