Publications by authors named "Ji-He Song"
Hypoxia inducible factor 1α (HIF‑1α) has been reported to play a key role in protecting neurons from ischaemic injury. However, the exact molecular mechanisms remain largely unclear. PC12 cells were exposed to oxygen glucose deprivation/reoxygenation (OGD/R) conditions to mimic ischaemic injury in vitro.
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- Alzheimer's disease (AD) is a neurodegenerative disorder where the role of lncRNA RMRP has mainly been studied in cancer, but its function in AD is unclear.
- The study used human serum samples, AD transgenic mice, and SH-SY5Y cells to assess the expressions of RMRP, miR-3142, and TRIB3, and examined their roles in apoptosis and autophagy.
- Results showed that knocking down RMRP reduced neuron death and autophagy, and RMRP appears to promote TRIB3 levels by sponging miR-3142, indicating that targeting RMRP could be a potential treatment for AD.