Publications by authors named "Ji-Gang Lei"
Background: Human adipose stromal cells-derived extracellular vesicles (haMSC-EVs) have been shown to alleviate inflammation in acute lung injury (ALI) animal models. However, there are few systemic studies on clinical-grade haMSC-EVs. Our study aimed to investigate the manufacturing, quality control (QC) and preclinical safety of clinical-grade haMSC-EVs.
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- Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) show potential as a cell-free therapy for lung injuries, particularly through nebulization of human adipose-derived MSC-EVs (haMSC-EVs).
- In a preclinical study, nebulization improved survival rates in a murine lung injury model, reducing inflammation and histological damage.
- Safety trials with 24 healthy volunteers indicated that haMSC-EVs were well-tolerated, with no serious adverse effects reported, supporting their future clinical use for lung injury treatments.