Publications by authors named "Ji-De A"
Article Synopsis
- Hepatic alveolar echinococcosis is a zoonotic disease prevalent in western China, especially in regions like Qinghai, Tibet, and Xinjiang.
- Research shows that neovascularization in this disease is linked to the overexpression of VEGFA and HIF-1α, which play key roles in angiogenesis.
- The article explores the potential for treating hepatic alveolar echinococcosis by targeting signaling pathways similar to those used in liver cancer therapies, focusing on the biological roles of HIF-1α, VEGFA, and the BMP9-ID1 signaling pathway.
Article Synopsis
- * Current treatment primarily involves surgery or lifelong use of anti-AE medications like albendazole and mebendazole, which can manage the disease but are not curative and may cause harmful side effects.
- * New potential therapies are being explored, including synthetic and natural compounds, which aim to improve effectiveness and reduce side effects by targeting the parasitic metabolism and structure, with ongoing research to refine these treatment options.
Background: Hepatic cystic and alveolar echinococcosis coinfections, particularly with concurrent abscesses and sinus tract formation, are extremely rare. This article presents a case of a patient diagnosed with this unique presentation, discussing the typical imaging manifestations of both echinococcosis types and detailing the diagnosis and surgical treatment experience thereof.
Case Summary: A 39-year-old Tibetan woman presented with concurrent hepatic cystic and alveolar echinococcosis, accompanied by abdominal wall abscesses and sinus tract formation.
Historical changes in surgical strategy and complication management for hepatic cystic echinococcosis.
World J Gastrointest Surg
August 2023
Echinococcosis is a zoonotic parasitic disease caused by Escherichia larvae. It frequently involves the liver (70%-75%), followed by the lungs (15%-20%), and occasionally the brain, heart, spleen, bone, and other organs. The main pathogenic forms of human echinococcosis currently include cystic echinococcosis (CE) and alveolar echinococcosis (AE).
View Article and Find Full Text PDFDiagnosis and treatment of mixed infection of hepatic cystic and alveolar : Four case reports.
World J Clin Cases
September 2020
Background: Mixed infection of hepatic cystic and alveolar is extremely rare. This article reveals the typical imaging manifestations of cystic and alveolar and investigates the diagnosis and surgical experience of mixed infection of hepatic cystic and alveolar .
Case Summary: From January 2017 to May 2019, 4 cases with rare mixed infection of hepatic cystic and alveolar were admitted and treated by the Division of General Surgery of Qinghai Provincial People's Hospital.
[Changes of inflammatory factors after hepatic cystic echinococcosis surgery and intervention of ulinastatin in Qinghai area].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
February 2019
Objective: To observe the changes of inflammatory factors after the hepatic cystic echinococcosis surgery and explore the intervention effect of ulinastatin on postoperative inflammatory factors.
Methods: Sixty patients with hepatic cystic echinococcosis were selected and randomly divided into a control group and ulinastatin intervention group according to whether or not use ulinastatin. The peripheral venous blood was extracted in all the patients and the levels of IL-6, IL-8, IL-9, and IL-10 were detected by the ELISA method on the day before operation, 1 day, 3 days, 5 days and 7 days after operation, respectively.