Short- and long-term results of open laparoscopic multisegmental resection and anastomosis for synchronous colorectal cancer located in separate segments.

Background: It remains unclear whether laparoscopic multisegmental resection and anastomosis (LMRA) is safe and advantageous over traditional open multisegmental resection and anastomosis (OMRA) for treating synchronous colorectal cancer (SCRC) located in separate segments.

Aim: To compare the short-term efficacy and long-term prognosis of OMRA as well as LMRA for SCRC located in separate segments.

Methods: Patients with SCRC who underwent surgery between January 2010 and December 2021 at the Cancer Hospital, Chinese Academy of Medical Sciences and the Peking University First Hospital were retrospectively recruited.

lncRNA-PACER upregulates and PGE2 through the NF-κB pathway to promote the proliferation and invasion of colorectal-cancer cells.

Background: p50-associated cyclooxygenase-2 extragenic RNA (PACER) is a recently identified antisense long non-coding RNA (lncRNA) located on the upstream of the promoter region of cyclooxygenase-2 (). Preliminary studies have suggested that PACER is involved in the regulation of expression in macrophagocyte and osteosarcoma cells. However, the role of this lncRNA in colorectal cancer (CRC) remains elusive.

The Distinction of Clinicopathological Characteristics, Treatment Strategy and Outcome in Colorectal Cancer Patients With Synchronous vs. Metachronous Bone Metastasis.

The impact of the timing of bone metastasis (BM) diagnosis on colorectal cancer (CRC) patients is unclear. Our study aimed to explore the differences in clinicopathological characteristics, treatments and prognosis between synchronous BM (SBM) and metachronous BM (MBM) from CRC. We retrospectively investigated clinical data of CRC patients with SBM or MBM from 2008 to 2017 at Chinese National Cancer Center.

Evaluation of clinical significance of claudin 7 and construction of prognostic grading system for stage II colorectal cancer.

Background: Claudin 7 is often abnormally expressed in cancers and promotes the progression of some malignancies. However, the role of claudin 7 in stage II colorectal cancer (CRC) has not been studied.

Aim: To assess the expression and prognostic value of claudin 7 in stage II CRC.

A prognostic index model to individually predict clinical outcomes for colorectal cancer with synchronous bone metastasis.

The prognosis of synchronous bone metastasis (BM) in colorectal cancer (CRC) is poor and rarely concerned. A clinical tool to evaluate the prognosis and clinical outcomes for BM would be attractive in current clinical practice. A total of 342 CRC patients with synchronous BM were identified from Surveillance, Epidemiology, and End Results (SEER) database.

Prognostic scoring system for synchronous brain metastasis at diagnosis of colorectal cancer: A population-based study.

Background: Brain metastasis (BM) from colorectal cancer (CRC) is rarely encountered clinically, and its prognosis has not been fully evaluated.

Aim: To construct a scoring system and accurately predict the survival of patients with synchronous BM at diagnosis of CRC.

Methods: A retrospective study of 371 patients with synchronous BM from CRC was performed, using the data from 2010 to 2014 from the Surveillance, Epidemiology, and End Results database.

A clinical model to predict the risk of synchronous bone metastasis in newly diagnosed colorectal cancer: a population-based study.

Background: The early detection of synchronous bone metastasis (BM) in newly diagnosed colorectal cancer (CRC) affects its initial management and prognosis. A clinical model to individually predict the risk of developing BM would be attractive in current clinical practice.

Methods: A total of 55,869 CRC patients were identified from Surveillance, Epidemiology, and End Results (SEER) database, of whom 317 patients were diagnosed with synchronous BM.

GGN Promotes Tumorigenesis by Regulating Proliferation and Apoptosis in Colorectal Cancer.

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. GGN is a germ cell-specific gene, but its function in CRC has been rarely reported to date. The aim of this study was to investigate the potential role of GGN in CRC tumorigenesis.

Current practice patterns of preoperative bowel preparation in colorectal surgery: a nation-wide survey by the Chinese Society of Colorectal Cancer.

Background: The optimal preoperative bowel preparation for colorectal surgery remains controversial. However, recent studies have established that bowel preparation varies significantly among countries and even surgeons at the same institution. This survey aimed to obtain information on the current practice patterns of bowel preparation for colorectal surgery in China.

Validity and necessity of sub-classification of N3 in the 7th UICC TNM stage of gastric cancer.

Background: The 7th TNM staging is the first authoritative standard for evaluation of effectiveness of treatment of gastric cancer worldwide. However, revision of pN classification within TNM needs to be discussed. In particular, the N3 sub-stage is becoming more conspicuous.

[Clinicopathological characteristics and prognostic analysis of bone metastasis in gastric cancer patients].

Objective: To investigate the clinicopathological characteristics and prognostic factors of bone metastasis in gastric cancer patients.

Methods: Clinicopathological data of 66 gastric cancer patients with bone metastasis, who were treated at the Tianjin Medical University Cancer Institute and Hospital from October 1997 to September 2011, were analyzed retrospectively. The clinicopathological characteristics of the primary cancer and bone metastasis were summarized and the prognosis was analyzed.

[Treatment and prognostic analysis of early stage of primary gastric diffuse large B-cell lymphoma].

Objective: To explore the prognostic factors and to compare chemotherapy alone versus surgical resection plus chemotherapy for early stage primary gastric diffuse large B-cell lymphomas (DLBCL).

Methods: Clinical data of 75 patients who were diagnosed as primary gastric DLBCL between January 1993 and August 2008 in Cancer Institute and Hospital of Tianjin Medical University were reviewed retrospectively.

Results: Among these 75 patients, 20 patients received chemotherapy alone and 55 underwent surgical resection plus chemotherapy.

[A retrospective analysis of clinic-pathological characteristics and prognostic factors for 204 cases of primary gastric lymphoma].

Objective: To explore the clinicopathological characteristics and prognostic factors of primary gastric lymphoma (PGL).

Methods: The clinical data of 204 patients with PGL was reviewed and analyzed. There were 106 males and 98 females, their age were 19 to 85 years (average age was 53.

[Risk factors for early recurrence after radical resection of proximal gastric cancer].

Objective: To explore the risk factors for early recurrence (recurrence within 2 years) of proximal gastric cancer after radical resection.

Methods: The clinical data of 367 proximal gastric cancer patients who underwent radical resection in the Cancer Institute and Hospital of Tianjin Medical University between January 2000 and May 2006 were reviewed. Among them, there are 71 patients (19.