Publications by authors named "Ji-Cheng Wei"
Article Synopsis
- - Cerebral ischemia/reperfusion (I/R) injury can lead to severe brain damage and cognitive decline, and the study investigates the neuroprotective effects of low-density lipoprotein receptor-related protein-1 (LRP1) against this injury.
- - The researchers induced I/R injury in mice and treated them with the LRP1 ligand COG1410, finding that it improved neurobehavioral outcomes and reduced brain damage by modulating inflammation and oxidative stress.
- - COG1410's protective effects were linked to its ability to alter microglial polarization through the TXNIP/NLRP3 signaling pathway, although these benefits were negated when TXNIP was overexpressed, indicating a potential
BACKGROUND Studies in vivo have shown that dexmedetomidine (DEX) could protect the myocardium and modulate the coronary blood flow. This study aimed to investigate the direct and concentration-dependent effects of DEX on the tone of porcine coronary artery in vitro and the underlying mechanisms. MATERIAL AND METHODS Distal branches of the porcine anterior descending coronary arteries were dissected and cut into 3-5 mm rings.
View Article and Find Full Text PDFSepsis is associated with high morbidity and mortality. This study was to investigate the protective effects of electroacupuncture (EA) pretreatment with different waveforms on septic brain injury in rats and its mechanism. Male Sprague-Dawley rats were pretreated by EA with different waveforms (continuous wave, dilatational wave, or intermittent wave) at Baihui (GV20) and Tsusanli (ST36) acupoints for 30min, and underwent cecal ligation and puncture (CLP) or sham operation.
View Article and Find Full Text PDFA pair of primers was designed to amplify the propylene alcohol dehydrogenase gene sequence based on the cDNA sequence of the tobacco allyl-alcohol dehydrogenase gene. All introns were sequenced using traditional polymerase chain reaction (PCR) methods and T-A cloning. The sequences from common tobacco ( L.
View Article and Find Full Text PDF[Changes of hemodynamics during establishment of animal model of acute myocardial infarction induced by ligation of left coronary artery in goat].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
April 2006
Article Synopsis
- The study aimed to analyze hemodynamic changes in goats after inducing acute myocardial infarction by ligating the left coronary artery.
- The methods involved monitoring various heart and blood pressure metrics in 20 goats before and after the procedure, observing notable ECG changes over time.
- Results showed significant ST-segment elevation in most goats post-ligation, but no major hemodynamic changes; the study suggests this model is useful for further research on coronary heart disease.