ABCC2 p.R393W variant contributes to Dubin-Johnson syndrome by targeting MRP2 to proteasome degradation.

Background: Dubin-Johnson syndrome (DJS), a rare autosomal recessive liver condition, is caused by biallelic loss-of-function mutations of the gene. This study aimed to investigate genetic variations in the drug efflux transporter (MRP2) gene in patients with DJS and to characterise the expression and mechanism of the gene variant.

Methods: Trio whole exome sequencing was performed in the family to identify the genetic causes.

Activation of peroxymonosulfate by MgCoAl layered double hydroxide: Potential enhancement effects of catalyst morphology and coexisting anions.

The morphology and specific surface area of layered double hydroxide (LDH) are of great significance for optimizing the application of LDH in sewage treatment. Herein, we present a study of the relation between the catalytic property and the morphology of LDH via activating peroxymonosulfate (PMS) for degradation of organic pollutants. The results demonstrated that LDH nanoscrolls possessed a superior performance for methylene blue (MB) degradation, which achieved almost 100% removal in 40 min and the calculated apparent rate constant was about 2.