Publications by authors named "Ji-Ae Yoon"
Background: Controversy regarding the definition of the upper limit of normal (ULN) for dilated mid-ascending aorta (mAA) stems from variation in criteria, based on several small-sized studies with small datasets of normal subjects (DONS). The present study was carried out to demonstrate this variation in the prevalence of mAA dilation and to identify the optimal definition by creating the largest DONS.
Methods: Echocardiographic studies of patients ≥ 15 years of age performed at a large tertiary care center over 4 years ( = 49,330) were retrospectively evaluated.
Background: We aimed to test the hypothesis that there is an association between hypertrophic cardiomyopathy and dilated aorta in a case-control, matched-design fashion.
Methods: Of 65,843 studies done from November 2011 to December 2015, we found, after detailed evaluation by a single author, 153 cases of hypertrophic cardiomyopathy and 3,213 controls who were classified as normal clinically and echocardiographically. Controls were defined as normal patients referred to the echocardiography laboratory with no diagnoses and no known risk factors for dilated aorta (e.
Introduction: Triage, a process to determine illness severity, is implemented by emergency nurses to prioritize treatment and provide care for a maximum number of patients using limited resources. The competency of emergency nurses and a highly reliable triage are crucial for the provision of emergency care. Pediatric patients are different from adult patients in certain aspects, such as growth-phase characteristics, communication ability, and the onset of disease; these aspects often pose challenges during their primary triage.
View Article and Find Full Text PDFObjectives: The cutoff for dilated mid-ascending aorta (mAA) is controversial and has several definitions. The present study was carried out to determine the prevalence of mAA dilation based on published definitions and to identify the optimal cutoff.
Methods: Echocardiographic studies of patients >15 years of age performed at a large tertiary care center over 4 years, = 49,330, were retrospectively evaluated.
Purpose: To evaluate the safety and effectiveness of aflibercept in combination with fluorouracil, leucovorin, and irinotecan (FOLFIRI) in Korean patients with metastatic colorectal cancer (mCRC) who progressed with oxaliplatin-containing regimen.
Methods: This was a prospective observational study conducted at 22 sites across Korea between February 2018 and September 2019. Patients aged > 19 years with a diagnosis of mCRC who were prescribed aflibercept plus FOLFIRI, after progression with an oxaliplatin-containing regimen were included.
Article Synopsis
- An estimated 2.4 million Americans, including veterans, are chronically infected with hepatitis C (HCV) and it's linked to both liver cancer and potentially other extrahepatic cancers (EHCs).
- The study reviewed data from 1541 patients at a VA clinic to examine the impact of liver fibrosis and chronic HCV infection on the risk of developing EHCs.
- Findings indicated that older age and higher liver stiffness measurements are significantly associated with an increased risk of EHCs, particularly prostate, head and neck, lung, and hematologic cancers.
Purpose: Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely because of a lack of systematic understanding of the molecular pathogenesis of the disease. To identify therapeutic targets and perform comparative analyses of lung SCC, we probed somatic genome alterations of lung SCC by using samples from Korean patients.
View Article and Find Full Text PDFArticle Synopsis
- Increasing shift work and trans-meridian travel disrupt circadian rhythms, leading to health issues like metabolic syndrome, obesity, and cardiovascular disorders.
- A study found that shifting meal times affected mice's activity levels and metabolic health, with earlier meals causing insulin resistance and later meals raising blood glucose levels.
- These findings suggest that changes in meal timing can significantly impact metabolism and health, highlighting concerns for individuals with irregular work or travel schedules.
Circadian clocks are the endogenous oscillators that harmonize a variety of physiological processes within the body. Although many urinary functions exhibit clear daily or circadian variation in diurnal humans and nocturnal rodents, the precise mechanisms of these variations are as yet unclear. In this review, we briefly introduce circadian clocks and their organization in mammals.
View Article and Find Full Text PDF