[Is immunohistochemistry for MLH1 and MSH2 proteins a useful method for detection of microsatellite instability in sporadic colorectal cancer?].

Background/aims: In order to identify microsatellite instability (MSI), the test based on the polymerase chain reaction (PCR) can be used. However, PCR is not routinely performed in all hospital laboratories. Recently, immunohistochemistry (IHC) for MLH1 and MSH2 proteins has been reported as a rapid and useful method for MSI.