Exploring the new model of medical innovation and entrepreneurship talent training based on biodesign in eastern China.

With the trend of economic globalization, innovation and entrepreneurship have become critical strategies for national development. College students, particularly, are a primary focus for cultivating awareness of innovation and entrepreneurship, which is essential for implementing national development strategies. The institution in eastern China has developed a program aimed at fostering medical innovation and entrepreneurship through the Biodesign framework.

Prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer after curative surgery: Final results of a phase II trial.

Objective: The trial was designed to evaluate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin for patients with locally advanced gastric cancer (LAGC).

Methods: Between March 2015 and November 2016, a phase II clinical trial was performed. Fifty consecutive patients with LAGC were randomly assigned to two groups: the experimental group (radical gastrectomy + HIPEC with cisplatin + adjuvant chemotherapy) and the control group (radical gastrectomy + adjuvant chemotherapy).

Copper-catalyzed chemoselective C-H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds.

Herein, a copper-catalyzed intermolecular [4+1] spiroannulation of indoles with alkynyldiazoketones affording various indole-based spirocyclic molecules a chemoselective C-H functionalization/dearomatization sequence was developed.

The role of Morin in attenuating atherosclerosis via STAT1 pathway inhibition.

Atherosclerotic cardiovascular diseases can lead to myocardial infarction and stroke, which are linked to elevated rates of mortality. Morin is a flavonoid compound that can be extracted from mulberries and possesses anti-inflammatory and antioxidant properties. The objective of this research is to elucidate Morin's impact on atherosclerosis.

Exosomes in Skin Flap Survival: Unlocking Their Role in Angiogenesis and Tissue Regeneration.

This review explores the critical role of exosomes in promoting angiogenesis, a key factor in skin flap survival. Skin flaps are widely used in reconstructive surgery, and their survival depends heavily on the formation of new blood vessels. Exosomes, small extracellular vesicles secreted by various cells, have emerged as important mediators of intercellular communication and play a crucial role in biological processes such as angiogenesis.

Identities and Spatial Distribution of Active Antioxidative Components in Ligustrum lucidum Ait. Leaves.

Despite that the leaves of Ligustrum lucidum Ait. (LLA) have been used in traditional Chinese medicine for more than 2000 years, their medicinal potential remains underexplored compared with the fruits of this plant species. Therefore, the aims of this study were to investigate the antioxidative activities of different solvent fractions of LLA leaf extract and to identify the active components and their spatial distribution within the leaf tissue.

Near-infrared fluorogenic RNA for in vivo imaging and sensing.

Fluorogenic RNA aptamers have various applications, including use as fluorescent tags for imaging RNA trafficking and as indicators of RNA-based sensors that exhibit fluorescence upon binding small-molecule fluorophores in living cells. Current fluorogenic RNA:fluorophore complexes typically emit visible fluorescence. However, it is challenging to develop fluorogenic RNA with near-infrared (NIR) fluorescence for in vivo imaging and sensing studies.

Fuzzy backstepping controller for agricultural tractor-trailer vehicles path tracking control with experimental validation.

Unmanned driving technology for agricultural vehicles is pivotal in advancing modern agriculture towards precision, intelligence, and sustainability. Among agricultural machinery, autonomous driving technology for agricultural tractor-trailer vehicles (ATTVs) has garnered significant attention in recent years. ATTVs comprise large implements connected to tractors through hitch points and are extensively utilized in agricultural production.

From materials to applications: a review of research on artificial olfactory memory.

Olfactory memory forms the basis for biological perception and environmental adaptation. Advancing artificial intelligence to replicate this biological perception as artificial olfactory memory is essential. The widespread use of various robotic systems, intelligent wearable devices, and artificial olfactory memories modeled after biological olfactory memory is anticipated.

Nucleotide coordinated polymers, a ROS-based immunomodulatory antimicrobial, doubly kill biofilms of implant infections.

causes high morbidity and mortality in nosocomial infections, and newly approved antibiotics have been declining for decades. A green and universal deprotonation-driven strategy is used to screen the guanylic acid-metal ion coordination polymer nanoparticles (GMC), instead of the failure of binding occurs when specific metal ion participation. We find that the precise pH-dependent oxidase-like activity of GMC-2 orchestrates a duple symphony of immune modulation for biofilm infections.

Molecular Eye: A System for Precise Diagnosis and Treatment of Major Clinical Diseases Based on Molecular Probe Technology.

With the flourishing development of precision medicine, theranostics, generally recognized as the integration of diagnosis and treatment, has emerged as a prominent trend in clinical research. However, theranostics primarily emphasizes the end result of integration, without providing sufficient details on how precise diagnosis and synergetic individualized treatment could be achieved and what clinical challenges could be effectively addressed in clinical practice. Molecular probe technology provides a robust method to bridge the gap between theory and practice.

Curcumin/pEGCG-encapsulated nanoparticles enhance spinal cord injury recovery by regulating CD74 to alleviate oxidative stress and inflammation.

Spinal cord injury (SCI) often accompanies impairment of motor function, yet there is currently no highly effective treatment method specifically for this condition. Oxidative stress and inflammation are pivotal factors contributing to severe neurological deficits after SCI. In this study, a type of curcumin (Cur) nanoparticle (HA-CurNPs) was developed to address this challenge by alleviating oxidative stress and inflammation.

Synthesis and Photodynamic Activities of Pyridine- or Pyridinium-Substituted Aza-BODIPY Photosensitizers.

In this work, various novel pyridinyl- and pyridinium-modified Aza-BODIPY PSs were designed and constructed based on monoiodo Aza-BODIPY PSs ( and ) in an attempt to construct "structure-inherent organelles-targeted" PSs to endow potential organelle-targeting ability. Pyridinyl PSs displayed potent photodynamic efficacy, and monorigidified PSs were very effective. The monorigidified PS with -pyridinyl moiety displayed the most potent photoactivity and negligible dark toxicity with a favorable dark/phototoxicity ratio (>4800).

A latent profile analysis of shift work tolerance among Chinese male sailors during a prolonged non-24-h rotating shift schedule at sea.

Shift work tolerance (SWT) refers to the ability to adapt to shift work without significant adverse consequences. The present study aimed to examine the individual differences in SWT and their predictors and outcomes. Latent profile analyses were conducted using cross-sectional data collected form 448 Chinese male sailors who experienced a prolonged (>30 d) non-24-h rotating shift schedule at sea.

The protective role of Cordyceps cicadae and its active ingredient myriocin against sodium iodate-induced age-related macular degeneration via an anti-necroptotic TNF-RIPK1/3 pathway.

Ethnopharmacological Relevance: Cordyceps cicadae (C.cicadae), named "Chan Hua", an anamorph of Isaria cicadae Miquel, is an entomogenous complex formed by fungi parasitizing on the larvae of cicadas and belongs to the Claviciptaceae family and the genus Codyceps, which traditionally holds a significant place in Chinese ethnopharmacology, specifically for eye clarity and as a remedy for age-related ocular conditions. The underlying mechanisms contributing to its eyesight enhancement and potential effectiveness against Age-related macular degeneration (AMD) remain unexplored.

Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK/STAT signaling pathway.

Background: Heat stroke (HS) generated liver injury is a lethal emergency that occurs when the body is exposed to temperatures up to 40 °C for a few hours.

Purpose: This study aimed to evaluate the therapeutic prospects of Catalpol (CA) from the blood-cooling herb Rehamanniae Radix on liver injury by HS.

Study Design And Methods: A murine HS model (41 ± 0.

Intratumoral microbiome is associated with gastric cancer prognosis and therapy efficacy.

The role of the intratumoral microbiome in gastric cancer (GC) has not been comprehensively assessed. Here, we explored the relationship between the microbial community and GC prognosis and therapy efficacy. Several cancer-associated microbial characteristics were identified, including increased α-diversity, differential β-diversity, and decreased abundance.

Detection and analysis of serum bile acid profile in patients with colonic polyps.

Background: Analyzing the variations in serum bile acid (BA) profile can provide a certain biological basis for early warning and prevention of various diseases. There is currently no comprehensive study on the relationship between the serum BA profile and colonic polyps.

Aim: To study the serum BA profile detection results of patients with colonic polyps, and analyze the correlation between BA and colonic polyps.

Chelator boosted tumor-retention and pharmacokinetic properties: development of Cu labeled radiopharmaceuticals targeting neurotensin receptor.

Purpose: Accumulating evidence suggests that neurotensin (NTS) and neurotensin receptors (NTSRs) play key roles in lung cancer progression by triggering multiple oncogenic signaling pathways. This study aims to develop Cu-labeled neurotensin receptor 1 (NTSR1)-targeting agents with the potential for both imaging and therapeutic applications.

Method: A series of neurotensin receptor antagonists (NRAs) with variable propylamine (PA) linker length and different chelators were synthesized, including [Cu]Cu-CB-TE2A-iPA-NRA ([Cu]Cu-4a-c, i = 1, 2, 3), [Cu]Cu-NOTA-2PA-NRA ([Cu]Cu-4d), [Cu]Cu-DOTA-2PA-NRA ([Cu]Cu-4e, also known as [Cu]Cu-3BP-227), and [Cu]Cu-DOTA-VS-2PA-NRA ([Cu]Cu-4f).

Enhancing the Lithium Storage Performance of the NbO Anode via Synergistic Engineering of Phase and Cu Doping.

NbO has been viewed as a promising anode material for lithium-ion batteries by virtue of its appropriate redox potential and high theoretical capacity. However, it suffers from poor electric conductivity and low ion diffusivity. Herein, we demonstrate the controllable fabrication of Cu-doped NbO with orthorhombic (T-NbO) and monoclinic (H-NbO) phases through annealing the solvothermally presynthesized NbO precursor under different temperatures in air, and the Cu doping amount can be readily controlled by the concentration of the precursor solution, whose effect on the lithium storage behaviors of the Cu-doped NbO is thoroughly investigated.