Heart failure subphenotypes based on mean arterial pressure trajectory identify patients at increased risk of acute kidney injury.

Background: Acute kidney injury (AKI) is a common complication in heart failure (HF) patients. Patients with heart failure who experience renal injury tend to have a poor prognosis. The objective of this study is to examine the correlation between the occurrence of AKI in heart failure patients and different mean arterial pressure (MAP) trajectories, with the goal of improving early identification and intervention for AKI.

Coordinated analysis of groundwater spatiotemporal chemical characteristics, water quality, and potential human health risks with sustainable development in semi-arid regions.

The emergence of large-scale time-series data and advancements in computational power have opened new avenues for analyzing the spatiotemporal evolution of groundwater chemistry, water quality, and human health risks. This paper utilizes hydrogeochemical methods to elucidate the controlling factors of water chemical components based on the test results of 124 groundwater samples collected from 31 monitoring wells in Fuxin City, Liaoning Province, China, from 2018 to 2021. By integrating the Random Forest and Enhanced Water Quality Index methods for water quality assessment and employing the Human Health Risk Assessment (HHRA) model to analyze human health risks, our findings indicate that the groundwater is mildly alkaline, with SO·Cl-Ca·Mg and HCO-Ca·Mg as the dominant hydrochemical types, primarily derived from the dissolution of carbonate and silicate minerals such as dolomite, limestone, and andesite, and cation exchange reactions.

The Role of AGGF1 in the Classification and Evaluating Prognosis of Adult Septic Patients: An Observational Study.

Purpose: Angiogenic factor with G patch and FHA domains 1 (AGGF1) is a crucial angiogenic factor that is involved in a variety of diseases and in the regulation of inflammatory responses. However, its role in sepsis is poorly understood. We have investigated the role of AGGF1 in the classification and prognostic evaluation of adult septic patients in a clinical context.

Acute muscle wasting is associated with poor prognosis in older adults with severe community-acquired pneumonia.

Purpose: To investigate the impact of acute muscle wasting on 90-day mortality in older patients with severe pneumonia using ultrasound and chest computed tomography (CT).

Methods: Quadriceps muscle layer thickness was measured via ultrasound on days 1, 7, and 14, and cross-sectional area of the erector spinae muscle was assessed using chest CT on days 1 and 14 in patients aged ≥ 65 years old. The primary outcome was all-cause 90-day mortality.

Early human albumin administration is associated with reduced mortality in septic shock patients with acute respiratory distress syndrome: A retrospective study from the MIMIC-III database.

Sepsis-induced acute respiratory distress syndrome (ARDS) was associated with higher mortality. It is unclear whether albumin supplementation early in the course of ARDS can affect the prognostic outcomes of septic shock (SS) patients with ARDS. The MIMIC-III database was employed to identify SS patients with ARDS.

Indoor Positioning with CNN and Path-Loss Model Based on Multivariable Fingerprints in 5G Mobile Communication System.

Many application scenarios require indoor positioning in fifth generation (5G) mobile communication systems in recent years. However, non-line of sight and multipath propagation lead to poor accuracy in a traditionally received signal strength-based fingerprints positioning system. In this paper, we propose a positioning method employing multivariable fingerprints (MVF) composed of measurements based on secondary synchronization signals (SSS).

Insights into the mechanism of enhanced peroxymonosulfate degraded tetracycline using metal organic framework derived carbonyl modified carbon-coated Fe.

Tetracycline (TC) is a commonly used antibiotic that has gained wide spread notoriety owing to its high environmental risks. In this study, rich carbonyl-modified carbon-coated Fe was obtained by pyrolysis of MIL-100(Fe) in an Ar atmosphere, and used to activate peroxymonosulfate (PMS) for the degradation of tetracycline in water. The roles of Fe, carbon and surface carbonyl on PMS activation were investigated.

Uniform platinum nanoparticles loaded on Universitetet i Oslo-66 (UiO-66): Active and stable catalysts for gas toluene combustion.

Highly dispersed Pt nanoparticles supported UiO-66 catalysts were successfully prepared by the incipient wetness impregnation method. Their thermal catalytic performances were evaluated by toluene degradation. The physicochemical properties of the samples were characterized using a series of characterization methods.

Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy.

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-induced circulatory and cardiac dysfunction is associated with high mortality rates. Mitophagy, a specific form of autophagy, is excessively activated in lipopolysaccharide-induced myocardial injury.

Ripple mapping-guided atrial tachycardia ablation following open-heart surgery.

Ripple mapping can make the visualization of activation conduction on a 3-dimensional voltage map and is useful tool for scar-related organized atrial tachycardia (AT). This study sought to assess the efficacy of ripple mapping for interpreting reentrant circuits and critical isthmus in postoperative ATs. 34 consecutive patients with a history of mitral valve surgery (mean age, 54.

Glycolytic and lipid oxidative metabolic programs are essential for freshly-isolated regulatory T cells in mice with sepsis.

Immunometabolism determines the fate and function of regulatory T cells. The metabolic phenotype of regulatory T cells (Treg) is affected by various factors. The relationship between Treg metabolism and function of mice with sepsis is not clear.

Insights to perfluorooctanoic acid adsorption micro-mechanism over Fe-based metal organic frameworks: Combining computational calculation with response surface methodology.

Adsorption performance, interfacial interaction mechanism and contribution of pores concerning PFOA adsorption to Fe-based metal-organic frameworks (MOFs) including Fe-BTC, MIL-100-Fe and MIL-101-Fe are investigated using experiments and computational calculation at molecular level even electronic level. Fe-BTC (418 mg/g) with more Lewis acid sites demonstrates higher adsorption capacity of PFOA in comparison with MIL-100-Fe (349 mg/g) and MIL-101-Fe (370 mg/g). Adsorption isotherms and kinetics indicate presence of monolayer adsorption and chemisorption in adsorption process.

Community-acquired bacterial co-infection predicts severity and mortality in influenza-associated pneumonia admitted patients.

Background: Influenza is frequently complicated by bacterial co-infection, causing additional hospitalization and mortality. We determined the incidence, risk factors and outcomes of patients with influenza-associated community-acquired bacterial co-infection.

Method: This was a retrospective, observational study.

Recognition of Latent Fingerprints and Ink-Free Printing Derived from Interfacial Segregation of Carbon Dots.

Carbon dots (CDs) have attracted increasing interest in recent years owing to their desirable properties. Despite the availability of diverse elaborate CDs, the function and application of CDs are far to be fully exploited. Here, biomass-derived carbon dots dispersed in a polymer matrix are found to behave as ink-free patterned substrates, which are demonstrated to be useful for nondestructive collection and recognition of latent fingerprints (LFPs), as well as printing.

The evaluation of acute physiology and chronic health evaluation II score, poisoning severity score, sequential organ failure assessment score combine with lactate to assess the prognosis of the patients with acute organophosphate pesticide poisoning.

The aim of this study was to assess the ability of acute physiology and chronic health evaluation II (APACHE II) score, poisoning severity score (PSS) as well as sequential organ failure assessment (SOFA) score combining with lactate (Lac) to predict mortality in the Emergency Department (ED) patients who were poisoned with organophosphate.A retrospective review of 59 stands-compliant patients was carried out. Receiver operating characteristic (ROC) curves were constructed based on the APACHE II score, PSS, SOFA score with or without Lac, respectively, and the areas under the ROC curve (AUCs) were determined to assess predictive value.

Sex-specific mortality differences in heart failure patients with ischemia receiving cardiac resynchronization therapy.

Background: Recent studies have reported prognosis differences between male and female heart failure patients following cardiac resynchronization therapy (CRT). However, the potential clinical factors that underpin these differences remain to be elucidated.

Methods: A meta-analysis was performed to investigate the factors that characterize sex-specific differences following CRT.

Aldehyde Dehydrogenase 2 Has Cardioprotective Effects on Myocardial Ischaemia/Reperfusion Injury via Suppressing Mitophagy.

Mitophagy, a selective form of autophagy, is excessively activated in myocardial ischemia/reperfusion (I/R). The study investigated whether aldehyde dehydrogenase 2 (ALDH2) exerted its cardioprotective effect by regulating mitophagy. Myocardial infarct size and apoptosis after I/R in rats were ameliorated by Alda-1, an ALDH2 activator, and aggravated by ALDH2 inhibition.

Direct Synthesis of Multicolor Fluorescent Hollow Carbon Spheres Encapsulating Enriched Carbon Dots.

Multicolor fluorescent hollow carbon spheres (HCSs) are fabricated by an easy one-step route of in situ pyrolysis process with the use of natural scales and collagen powders as the precursor. The gas blow forming mechanism and photoluminescence (PL) emission mechanism of HCSs have been thoroughly discussed and proved that HCSs represent the first examples of three-dimensional multicolor fluorescent nanomaterials based on carbon dots (CDs). The HCSs encapsulate enriched carbon dots with high quantum yields (QYs) of 38%, and thus are applied in inkjet printing and sensitized solar cells.

Alpha-lipoic acid ameliorates oxidative stress by increasing aldehyde dehydrogenase-2 activity in patients with acute coronary syndrome.

Aldehyde dehydrogenase-2 (ALDH2) is the main enzyme responsible for acetaldehyde oxidation in ethanol metabolism and also provides protection against oxidative stress. Alpha-lipoic acid (α-LA), a natural dithiol compound with antioxidant properties, has been reported to increase ALDH2 activity in cultured cells. We analyzed the therapeutic efficacy of α-LA in 63 patients with confirmed acute coronary syndrome (ACS).

The polymorphism in aldehyde dehydrogenase-2 gene is associated with elevated plasma levels of high-sensitivity C-reactive protein in the early phase of myocardial infarction.

Aldehyde dehydrogenase-2 (ALDH2) is a key enzyme of alcohol metabolism, catalyzing the conversion of aldehyde to acetic acid. The G-to-A polymorphism in exon 12 of the ALDH2 gene, which causes Glu-to-Lys substitution at codon 504, has been shown to be an independent risk factor for acute myocardial infarction (AMI). We investigated the possible role of the G-to-A polymorphism in the severity of the myocardial damage in the early phase of AMI by measuring plasma levels of inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP).

Meta-analysis of the role of high-dose statins administered prior to percutaneous coronary intervention in reducing major adverse cardiac events in patients with coronary artery disease.

1. There is considerable evidence regarding the efficacy of statins for the primary and secondary prevention of coronary artery disease (CAD). However, due to lack of sufficient evidence, there is still doubt whether high-dose statin therapy prior to percutaneous coronary intervention (PCI) is beneficial.