Tisotumab vedotin extravasation injury in a patient with recurrent cervical cancer.

•Infusion site extravasation injury is a rare but serious adverse event of tisotumab vedotin.•Central venous access device should be considered in patients with risk factors receiving antibody drug conjugate therapy.•Topical steroids may be used as part of supportive measures.

Watching hands move enhances learning from concrete and dynamic visualizations.

This article explores the role of sensorimotor engagement in students' learning of a challenging science, technology, engineering, and math-related concept. Previous research has failed to distinguish two features commonly associated with embodiment: sensorimotor engagement and visuospatial concreteness. In the current research, we ask whether sensorimotor engagement-operationalized as watching a video of hands manipulating paper representations-offers unique benefits beyond the visuospatial concreteness of a dynamic visualization of the same process.

A Randomized, Multi-Center, Open Label Study to Compare the Safety and Efficacy between Afatinib Monotherapy and Combination Therapy with HAD-B1 for the Locally Advanced or Metastatic NSCLC Patients with EGFR Mutations.

Background: Lung cancer, especially non-small cell lung cancer (NSCLC), poses a significant health challenge globally due to its high mortality. Afatinib, a second-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), has shown superior efficacy over traditional chemotherapy in NSCLC treatment. However, issues like secondary resistance and adverse effects call for alternative therapies.

A library for innovative category exemplars (ALICE) database: Streamlining research with printable 3D novel objects.

This paper introduces A Library for Innovative Category Exemplars (ALICE) database, a resource that enhances research efficiency in cognitive and developmental studies by providing printable 3D objects representing 30 novel categories. Our research consists of three experiments to validate the novelty and complexity of the objects in ALICE. Experiment 1 assessed the novelty of objects through adult participants' subjective familiarity ratings and agreement on object naming and descriptions.

Exosomal miR-196b secreted from bronchial epithelial cells chronically exposed to low-dose PM promotes invasiveness of adjacent and lung cancer cells.

Fine particulate matter (PM) is a risk factor for pulmonary diseases and lung cancer, and inhaled PM is mainly deposited in the bronchial epithelium. In this study, we investigated the effect of long-term exposure to low-dose PM on BEAS-2B cells derived from the normal bronchial epithelium. BEAS-2B cells chronically exposed to a concentration of 5 µg/ml PM for 30 passages displayed the phenotype promoting epithelial-mesenchymal transition (EMT) and cell invasion.

Lytic transglycosylase repertoire diversity enables intrinsic antibiotic resistance and daughter cell separation in under acidic stress.

Peptidoglycan (PG) is an important architectural element that imparts physical toughness and rigidity to the bacterial envelope. It is also a dynamic structure that undergoes continuous turnover or autolysis. possesses redundant PG degradation enzymes responsible for PG turnover; however, the advantage afforded by the existence of numerous PG degradation enzymes remains incompletely understood.

Short tandem repeat expansions in cortical layer-specific genes implicate in phenotypic severity and adaptability of autism spectrum disorder.

Aim: Short tandem repeats (STRs) are repetitive DNA sequences and highly mutable in various human disorders. While the involvement of STRs in various genetic disorders has been extensively studied, their role in autism spectrum disorder (ASD) remains largely unexplored. In this study, we aimed to investigate genetic association of STR expansions with ASD using whole genome sequencing (WGS) and identify risk loci associated with ASD phenotypes.

Clinical and Genomic Landscape of RAS Mutations in Gynecologic Cancers.

Purpose: We aimed to describe RAS mutations in gynecologic cancers as they relate to clinicopathologic and genomic features, survival, and therapeutic implications.

Experimental Design: Gynecologic cancers with available somatic molecular profiling data at our institution between February 2010 and August 2022 were included and grouped by RAS mutation status. Overall survival was estimated by the Kaplan-Meier method, and multivariable analysis was performed using the Cox proportional hazard model.

Identification and validation of and methylation for detecting lung cancer in bronchial washing sample.

Bronchoscopy is a frequently used initial diagnostic procedure for patients with suspected lung cancer (LC). Cytological examinations of bronchial washing (BW) samples obtained during bronchoscopy often yield inconclusive results regarding LC diagnosis. The present study aimed to identify molecular biomarkers as a non-invasive method for LC diagnosis.

Watching videos of a drawing hand improves students' understanding of the normal probability distribution.

Understanding normal probability distributions is a crucial objective in mathematics and statistics education. Drawing upon cognitive psychology research, this study explores the use of drawings and visualizations as effective scaffolds to enhance students' comprehension. Although much research has documented the helpfulness of drawing as a research tool to reveal students' knowledge states, its direct utility in advancing higher-order cognitive processes remains understudied.

Development of a new broad-spectrum microencapsulation-based spray drying formulation of subsp. IMBL-B9 for the control of moths.

Certain (Bt) strains such as Bt subsp. and Bt subsp. have been widely used for pest management in agricultural practices.

Photosynthetic responses of large old Zelkova serrata (Thunb.) Makino trees to different growth environments.

Large old trees, which provide ecosystem services and serve as a historical and cultural heritage, are exposed to various environmental threats, such as habitat fragmentation and climate change, necessitating diagnosis of tangible and intangible stresses and their effects on tree growth for effective management. This study investigated the photosynthetic characteristics of 25 large old Zelkova serrata (Thunb.) Makino trees in Chungcheong Province, Korea, and identified the physical environmental factors affecting their physiological responses.

Effect of Mixture of Recombinant Human Bone Morphogenic Protein-2 and Demineralized Bone Matrix in Lateral Lumbar Interbody Fusion.

Objective: This study aims to determine the optimal dose of recombinant-human bone morphogenic protein-2 (rhBMP-2) for successful bone fusion in minimally invasive lateral lumbar interbody fusion (MIS LLIF). Previous studies show that rhBMP is an effective alternative to autologous iliac crest bone graft, but the optimal dose remains uncertain. The study analyzes the fusion rates associated with different rhBMP doses to provide a recommendation for the optimal dose in MIS LLIF.

Synthesis and Volatility Characterization of Mo(II) and W(II) Compounds for Thin Films.

Mo(II) and W(II) compounds, Mo(η-allyl)(CO)(Tri-MEDA)Br (), Mo(η-allyl)(CO)(TMEDA)Br (), W(η-allyl)(CO)(Tri-MEDA)Br (), and W(η-allyl)(CO)(TMEDA)Br () (Tri-MEDA = ,,'-trimethylethylenediamine), were synthesized and characterized. The molecular structures of and were nearly identical with a pseudo-octahedral geometry except for the different Mo and W metal centers. The thermogravimetric analysis of and showed approximately 53 and 64% residues at 550 °C, respectively, which were significantly higher than the values for the expected materials.

Comparison of Plasma Metabolites From Patients With Non-Small Cell Lung Cancer by Erlotinib Treatment and Skin Rash.

Erlotinib is a necessary anticancer treatment for non-small cell lung cancer (NSCLC) patients yet it causes severe side effects such as skin rash. In this study, researchers compared the untargeted compound profiles before and after erlotinib administration to observe changes in blood metabolites in NSCLC patients. The levels of 1005 substances changed after taking erlotinib.

Ecoinformatic Analysis of the Gut Ecological Diversity of Wild and Captive Long-Tailed Gorals Using Improved ITS2 Region Primers to Support Their Conservation.

Ex situ conservation is used to protect endangered wildlife. As captive and wild long-tailed gorals are known to be similar, individuals under ex situ conservation can be reintroduced into nature. However, there is no appropriate indicator to evaluate them.

Representational-mapping strategies improve learning from an online statistics textbook.

Using multiple representations is an important part of learning and problem-solving in science, technology, engineering and mathematics fields. For students to acquire flexible knowledge of representations, they must attend to the structural information within each representation and practice making relational connections between representations. Most studies so far have only attempted to help students connect between multiple representations in the lab or short-term classroom interventions, with the intervention largely separated from students' authentic learning.

Synthesis and Characterization of Tungsten Amide Complexes for the Deposition of Tungsten Disulfide Thin Films.

To substitute corrosive halogen ligands, we designed and synthesized novel tungsten complexes containing amido ligands, W(DMEDA) () and W(DEEDA) () (DMEDA = ,'-dimethylethylenediamido; DEEDA = ,'-diethylethylenediamido). Complexes and were characterized by H NMR, C NMR, FT-IR, and elemental analysis. The pseudo-octahedral molecular structure of was confirmed by single-crystal X-ray crystallography.

Coordinated and Distinct Roles of Peptidoglycan Carboxypeptidases DacC and DacA in Cell Growth and Shape Maintenance under Stress Conditions.

Peptidoglycan (PG) is an essential bacterial architecture pivotal for shape maintenance and adaptation to osmotic stress. Although PG synthesis and modification are tightly regulated under harsh environmental stresses, few related mechanisms have been investigated. In this study, we aimed to investigate the coordinated and distinct roles of the PG dd-carboxypeptidases (DD-CPases) DacC and DacA in cell growth under alkaline and salt stresses and shape maintenance in Escherichia coli.

Correlates of burnout among healthcare workers during the COVID-19 pandemic in South Korea.

Burnout is a form of negative emotional and physical response to job stress. This study aimed to investigate the prevalence of burnout among healthcare workers responding to the coronavirus disease 2019 (COVID-19) outbreak in Korea and to explore correlates of burnout among healthcare workers. A nationwide questionnaire-based survey was conducted from December 1, 2020, to January 29, 2021 on 1425 healthcare workers who worked in one of the 16 healthcare facilities designated for COVID-19 care, in public health centers, or as paramedics in Korea.