Pathology-Independent Expansion of Indications for Rapid-Deployment Aortic Valve Replacement: Midterm Outcomes.

Background:  This study evaluated the midterm outcomes of rapid deployment aortic valve replacement (RDAVR) performed regardless of pathology for various aortic valve diseases at a single center.

Methods:  Of the 344 patients who underwent RDAVR using Edwards INTUITY during the study period at our institution, 176 had bicuspid valve diseases (51.2%), 20 had pure aortic regurgitation (5.

Stabilizing Schottky-to-Ohmic Switching in HfO-Based Ferroelectric Films via Electrode Design.

The discovery of ferroelectric phases in HfO-based films has reignited interest in ferroelectrics and their application in resistive switching (RS) devices. This study investigates the pivotal role of electrodes in facilitating the Schottky-to-Ohmic transition (SOT) observed in devices consisting of ultrathin epitaxial ferroelectric HfYO (YHO) films deposited on LaSrMnO-buffered Nb-doped SrTiO (NbSTO|LSMO) with Ti|Au top electrodes. These findings indicate combined filamentary RS and ferroelectric switching occurs in devices with designed electrodes, having an ON/OFF ratio of over 100 during about 10 cycles.

Immunomodulation Effects of Porcine Cartilage Acellularized Matrix (pCAM) for Osteoarthritis Treatment.

Background: Pain reduction, immunomodulation, and cartilage repair are key therapeutic goals in osteoarthritis (OA) treatment. In this study, we evaluated the therapeutic effects of porcine cartilage acellularized matrix (pCAM) derived from naive tissue and compared it with the synthetic material polynucleotides (PN) for OA treatment.

Methods: pCAM was produced from porcine cartilage through physicochemical processing.

Development and Evaluation of Five-in-One Vaccine Microneedle Array Patch for Diphtheria, Tetanus, Pertussis, Hepatitis B, and Type b: Immunological Efficacy and Long-Term Stability.

: The development of a five-in-one vaccine microneedle patch (five-in-one MN patch) aims to address challenges in administering vaccines against Diphtheria (DT), Tetanus (TT), Pertussis (wP), Hepatitis B (HBsAg), and type b (Hib). Combining multiple vaccines into a single patch offers a novel solution to improve vaccine accessibility, stability, and delivery efficiency, particularly in resource-limited settings. : The five-in-one MN patch consists of four distinct microneedle arrays: DT and TT vaccines are coated together on one array, while wP, HepB, and Hib vaccines are coated separately on individual arrays.

Prognosis of patients with breast cancer who underwent breast-conserving surgery using a 3D-printed surgical guide after neoadjuvant chemotherapy.

In breast-conserving surgery (BCS), clear resection margins are crucial to prevent recurrence. Accurate imaging is vital for precise BCS, with MRI being the most accurate. However, MRI has limitations in identifying the exact extent of breast cancer in patients who have undergone neoadjuvant chemotherapy (NACT).

Synergistically Inducing Ultrafast Ion Diffusion and Reversible Charge Transfer in Lithium Metal Batteries Using Bimetallic Molybdenum-Titanium MXenes.

Metal batteries have captured significant attention for high-energy applications, owing to their superior theoretical energy densities. However, their practical viability is impeded by severe dendrite formation and poor cycling stability. To alleviate these issues, a 3D-structured bimetallic-MoTiCT based fiber electrode was fabricated in this study and analyzed experimentally and computationally.

Update on Resection Strategies for Hepatocellular Carcinoma: A Narrative Review.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, the incidence of which is rising globally. Despite recent advancements in immunotherapeutic and surgical treatment modalities, the prognosis for HCC remains poor. The surgical treatment strategy for HCC comprises a multimodal effort that ranges from ablative therapy and surgical resection to liver transplantation.

General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors.

Background: To assess the association between discrepancies between general obesity and abdominal obesity and the risk of subsequent cardiovascular disease (CVD), including stroke, in breast cancer survivors.

Methods: We undertook a retrospective cohort study using data from the National Health Insurance Service of South Korea. Among 72,174 5-year breast cancer survivors aged 40 years and above, body mass index (BMI) and waist circumference (WC) were used to determine obesity status.

Association between Antibiotic Use and Subsequent Risk of Breast Cancer: A Nationwide Retrospective Cohort Study in South Korea.

Several studies have revealed a possible association between antibiotic use and breast cancer in the Western population of women. However, its association with the Asian population remains unclear. Data utilized in this nationwide population-based retrospective cohort study was obtained from the Korean National Health Insurance Service (NHIS) database.

Evolution of minimally invasive cholecystectomy: a narrative review.

Background: Laparoscopic cholecystectomy, being a prevalent abdominal surgical procedure, has transitioned through various innovative stages aimed at reducing the procedure's invasiveness. These stages encompass Single-Incision Laparoscopic Cholecystectomy (SILC), Mini Laparoscopic Cholecystectomy (MLC), Natural Orifice Transluminal Endoscopic Surgery (NOTES), and Robotic-Assisted Laparoscopic Cholecystectomy (RALC). The purpose of this review is to trace the evolution of minimally invasive cholecystectomy techniques, assess their status, and identify emerging trends and challenges in the field.

Radiation Therapy for Graves' Ophthalmopathy: When Is the Optimal Timing of Treatment and Evaluation.

Purpose: Despite the decades of using radiation therapy (RT) for Graves' ophthalmopathy, the effects and optimal timing remain unclear. We retrospectively analyzed to evaluate the overall efficacy and response, predictive factors, and the effective timing of RT by assessing steroid requirement after RT in patients without prior surgery.

Methods And Materials: Between 2008 and 2022, we analyzed 74 patients with Graves' ophthalmopathy who received RT to both orbits.

Impact of High-intensity Statin on Atrial Fibrillation after Off-Pump Coronary Artery Bypass.

Background:  There is uncertainty regarding the impact of high-intensity statins on postoperative outcomes in patients undergoing surgical myocardial revascularization. This study was conducted to evaluate the impact of high-intensity statin treatment on the occurrence rate of new-onset postoperative atrial fibrillation (POAF) after off-pump coronary artery bypass grafting (OPCAB).

Methods:  Six hundred and thirteen patients (66.

Dual-Modal Sensing Skin Adaptive to Daylight, Darkness, and Ultraviolet Light for Simultaneous Full-Field Deformation Measurement and Mechanoluminescence Responses.

Mechanoluminescence (ML) and digital image correlation (DIC) have emerged as promising optical methods to visualize and measure deformation fields. In this study, a dual-modal sensing skin, called the ML-DIC skin is introduced, that is capable of emitting ML and facilitating DIC measurements under various lighting conditions, including daylight, night or darkness, and UV irradiation. Four ML-DIC skins are fabricated with or without carbon nanotubes (CNTs) using a composite powder consisting of SrAl2O4: Eu,Dy (SAO), and acrylic resin, with CNT milling times of 48, 72, and 96 h for three of four skins, respectively.

The effects of sarcopenic obesity on immediate postoperative outcomes after pancreatoduodenectomy: a retrospective cohort study.

Purpose: Several studies have evaluated the impact of sarcopenic obesity (SO) on postoperative complications, including postoperative pancreatic fistula (POPF), in patients undergoing pancreatoduodenectomy (PD). Previous studies have shown that SO increases POPF, but it remains unclear whether SO increases postoperative complications. In this study, we aimed to determine the relationship between SO and immediate postoperative complications.

Factors affecting fat myringoplasty in elderly patients with chronic otitis media: A case control study.

Background: We compared and analyzed the surgical results of fat myringoplasty between elderly and young adult patients with chronic otitis media. We also investigated whether underlying diseases and other factors impact the surgical outcome.

Methods: We retrospectively reviewed the data of 141 patients who underwent fat myringoplasty for chronic otitis media for five years.

Predictive Factors of Apparent Treatment Resistant Hypertension Among Patients With Hypertension Identified Using Electronic Health Records.

Background: Early identification of a patient with resistant hypertension (RH) enables quickly intensified treatment, short-interval follow-up, or perhaps case management to bring his or her blood pressure under control and reduce the risk of complications.

Objective: To identify predictors of RH among individuals with newly diagnosed hypertension (HTN), while comparing different prediction models and techniques for managing missing covariates using electronic health records data.

Design: Risk prediction study in a retrospective cohort.

Image-based ECG analyzing deep-learning algorithm to predict biological age and mortality risks: interethnic validation.

Background: Cardiovascular risk assessment is a critical component of healthcare, guiding preventive and therapeutic strategies. In this study, we developed and evaluated an image-based electrocardiogram (ECG) analyzing an artificial intelligence (AI) model that estimates biological age and mortality risk.

Methods: Using a dataset of 978 319 ECGs from 250 145 patients at Seoul National University Bundang Hospital, we developed a deep-learning model utilizing printed 12-lead ECG images to estimate patients' age (ECG-Age) and 1- and 5-year mortality risks.

Inhibition of WNK Kinases in NK Cells Disrupts Cellular Osmoregulation and Control of Tumor Metastasis.

Introduction: The serine/threonine with-no-lysine (WNK) kinase family function in blood pressure control, electrolyte homeostasis, and cellular osmoregulation. These kinases and their downstream effectors are considered promising therapeutic targets in hypertension and stroke. However, the role of WNK kinases in immune cells remains poorly understood.