[Analysis of the relationship between epistaxis and homocysteine and climatic factors in ultra-high altitude area].

To analyze the related influencing factors of epistaxis in extremely high altitude area, and to provide evidence for the prevention and treatment of epistaxis in extremely high altitude area. From January 2021 to December 2022, 206 outpatients with epistaxis, 54 inpatients with epistaxis and 69 inpatients withoutepistaxis in theDepartment of Otorhinolarygology, Naqu People's Hospital were collected. The previous history, drinking history, smoking history, serum homocysteine（Hcy）, white blood cell count（WBC）, red blood cell count（RBC）, hematocrit（HCT）, hemoglobin（HGB） and mean hemoglobin concentration（MCHC） were compared between inpatients with or without epistaxis.

A Genome-Wide Association Study Reveals the Genetic Mechanisms of Nutrient Accumulation in Spinach.

Spinach is a significant source of vitamins, minerals, and antioxidants. These nutrients make it delicious and beneficial for human health. However, the genetic mechanism underlying the accumulation of nutrients in spinach remains unclear.

A synchronous demodulation technology based on sample-and-hold for eddy current sensors.

This paper proposes a synchronous demodulation technology based on sample-and-hold which shows significant advantages in the application of precision sensors. The traditional synchronous demodulation methods are discussed, and then the working principle of the proposed method is theoretically analyzed in detail. It is found that the proposed method can not only effectively suppress the harmonic components caused by the signal source but is also beneficial to improving the dynamic range of precision sensors.

A neural circuit for flexible control of persistent behavioral states.

To adapt to their environments, animals must generate behaviors that are closely aligned to a rapidly changing sensory world. However, behavioral states such as foraging or courtship typically persist over long time scales to ensure proper execution. It remains unclear how neural circuits generate persistent behavioral states while maintaining the flexibility to select among alternative states when the sensory context changes.

Corollary discharge promotes a sustained motor state in a neural circuit for navigation.

Animals exhibit behavioral and neural responses that persist on longer timescales than transient or fluctuating stimulus inputs. Here, we report that uses feedback from the motor circuit to a sensory processing interneuron to sustain its motor state during thermotactic navigation. By imaging circuit activity in behaving animals, we show that a principal postsynaptic partner of the AFD thermosensory neuron, the AIY interneuron, encodes both temperature and motor state information.

tert-Butyl nitrite (TBN) as the N atom source for the synthesis of substituted cinnolines with 2-vinylanilines and a relevant mechanism was studied.

A green method to synthesize cinnolines by 6π electrocyclic reaction with alkenyl amines and TBN has been developed. TBN plays a dual role both as a nitrogen atom source and an oxidant in this procedure. Relevant mechanism experiments reveal that the reaction proceeds through electrocyclic reaction and with diazo hydroxide as a key intermediate.

Hydra: Imaging Nerve Nets in Action.

Mapping whole-brain activity during behavior represents one of the biggest and most exciting challenges of systems neuroscience. New research has taken advantage of the unique biology of an ancient organism to bring us a step closer to that goal.

Neuroendocrine modulation sustains the forward motor state.

Neuromodulators shape neural circuit dynamics. Combining electron microscopy, genetics, transcriptome profiling, calcium imaging, and optogenetics, we discovered a peptidergic neuron that modulates motor circuit dynamics. The Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID.

Pan-neuronal imaging in roaming Caenorhabditis elegans.

We present an imaging system for pan-neuronal recording in crawling Caenorhabditis elegans. A spinning disk confocal microscope, modified for automated tracking of the C. elegans head ganglia, simultaneously records the activity and position of ∼80 neurons that coexpress cytoplasmic calcium indicator GCaMP6s and nuclear localized red fluorescent protein at 10 volumes per second.

Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans.

Members of the Wnt family of secreted signaling proteins are key regulators of cell migration and axon guidance. In the nematode C. elegans, the migration of the QR neuroblast descendants requires multiple Wnt ligands and receptors.

Feedback control of gene expression variability in the Caenorhabditis elegans Wnt pathway.

Variability in gene expression contributes to phenotypic heterogeneity even in isogenic populations. Here, we used the stereotyped, Wnt signaling-dependent development of the Caenorhabditis elegans Q neuroblast to probe endogenous mechanisms that control gene expression variability. We found that the key Hox gene that orients Q neuroblast migration exhibits increased gene expression variability in mutants in which Wnt pathway activity has been perturbed.

Deconvolving the roles of Wnt ligands and receptors in sensing and amplification.

Establishment of cell polarity is crucial for many biological processes including cell migration and asymmetric cell division. The establishment of cell polarity consists of two sequential processes: an external gradient is first sensed and then the resulting signal is amplified and maintained by intracellular signaling networks usually using positive feedback regulation. Generally, these two processes are intertwined and it is challenging to determine which proteins contribute to the sensing or amplification process, particularly in multicellular organisms.

Wandering neuronal migration in the postnatal vertebrate forebrain.

Most non-mammalian vertebrate species add new neurons to existing brain circuits throughout life, a process thought to be essential for tissue maintenance, repair, and learning. How these new neurons migrate through the mature brain and which cues trigger their integration within a functioning circuit is not known. To address these questions, we used two-photon microscopy to image the addition of genetically labeled newly generated neurons into the brain of juvenile zebra finches.

The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts.

Wnt proteins are secreted signaling molecules that play a central role in development and adult tissue homeostasis. Although several Wnt signal transduction mechanisms have been described in detail, it is still largely unknown how cells are specified to adopt such different Wnt signaling responses. Here, we have used the stereotypic migration of the C.

Mild and efficient CO-mediated eliminative deoxygenation of epoxides catalyzed by supported gold nanoparticles.

Supported gold nanoparticles (NPs), which are well-known epoxidation catalysts, were found to be exceptionally active for the selective deoxygenation of epoxides into alkenes using cheap and easily accessible CO and H(2)O as the reductant.

Gold supported on hydroxyapatite as a versatile multifunctional catalyst for the direct tandem synthesis of imines and oximes.

Two birds with one auric stone: The title system acts as a highly efficient heterogeneous catalyst for the one-pot tandem synthesis of imines or oximes from alcohols and the corresponding amines under mild conditions (see scheme; HAP = hydroxyapatite).

Photooxygenation of hydrocarbons over efficient and reusable decatungstate heterogenized on hydrophobically-modified mesoporous silica.

Decatungstate W(10)O(32)(4-) heterogenized on a novel hydrophobically-organomodified SBA-15 was proven an efficient, green and reusable catalyst for photooxygenation by oxygen of a range of aryl alkanes to the corresponding ketones under mild conditions.

Efficient and chemoselective reduction of carbonyl compounds with supported gold catalysts under transfer hydrogenation conditions.

A new heterogeneous catalytic transfer hydrogenation (CTH) system, consisting of a non-flammable supported Au catalyst along with 2-propanol as the hydrogen donor, was proven to be effective for chemoselective reduction of a wide range of aromatic ketones and aldehydes to the corresponding alcohols.