COVID-19 acts like a stress test, uncovering the vulnerable part of the human body: a retrospective study of 1640 cases in China.

Background: Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection exhibits multi-organ damage with diverse complications, the correlation between age, gender, medical history and clinical manifestations of novel coronavirus disease 2019 (COVID-19) patients was investigated.

Methods: 1640 patients who were infected with SARS-CoV-2 and hospitalized at the First Affiliated Hospital of Ningbo University from 22 December 2022 to 1 March 2023 were categorized and analysed. Normal distribution test and variance homogeneity test were performed.

Lipid metabolism: the potential targets for toxoplasmosis treatment.

Toxoplasmosis is a zoonosis caused by Toxoplasma gondii (T. gondii). The current treatment for toxoplasmosis remains constrained due to the absence of pharmaceutical interventions.

Monoterpenoid indole alkaloids from Alstonia scholaris and their Toxoplasma gondii inhibitory activity.

Nine previously unreported various types of monoterpenoid indole alkaloids, together with seven known analogues were isolated from the stem barks of Alstonia scholaris through a silica gel free methodology. The structures of 1-9 were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Compound 1 is a modified echitamine-type alkaloid with a novel 6/5/5/7/6/6 hetero hexacyclic bridged ring system, and 8 and 9 exist as a zwitterion and trifluoroacetate salt, respectively.

Protective Immunity Induced by TgMIC5 and TgMIC16 DNA Vaccines Against Toxoplasmosis.

is an obligate intracellular parasite, which is responsible for a widely distributed zoonosis. Effective vaccines against toxoplasmosis are necessary to protect the public health. The aim of this study is to evaluate the immune efficacy of DNA vaccines encoding TgMIC5 and TgMIC16 genes against infection.

High prevalence of fasciolosis and evaluation of the efficacy of anthelmintics against in buffaloes in Guangxi, China.

is a common parasite of grazing livestock in Guangxi Zhuang Autonomous Region in China, but its prevalence has not been studied. While triclabendazole is commonly used to treat infection in China, oxyclozanide has never been used. This study investigated the prevalence of infections in buffaloes in the Guangxi and evaluated the efficacy of oxyclozanide and triclabendazole as treatments.

New life for an old drug: In vitro and in vivo effects of the anthelmintic drug niclosamide against Toxoplasma gondii RH strain.

Toxoplasma gondii is the causative agent of toxoplasmosis and causes serious public health problems. However, the current treatment drugs have many limitations, such as serious side effects. Niclosamide is a salicylanilide drug commonly used to treat worm infections.

[Fire behavior of Quercus mongolica leaf litter fuelbed under zero-slope and no-wind conditions. II. Analysis and modelling of fireline intensity, fuel consumption, and combustion efficiency].

Mongolian oak (Quercus mongolica) is an important constructive and accompanying species in mixed broadleaf-conifer forest in Northeast China, In this paper, a laboratory burning experiment was conducted under zero-slope and no-wind conditions to study the effects of fuel moisture content, loading, and thickness on the fireline intensity, fuel consumption, and combustion efficiency of the Mongolian oak leaf litter fuelbed. The fuel moisture content, loading, and thickness all had significant effects on the three fire behavior indices, and there existed interactions between these three affecting factors. Among the known models, the Byram model could be suitable for the prediction of local leaf litter fire intensity only after re-parameterization.

[Lightning-caused fire, its affecting factors and prediction: a review].

Lightning-caused fire is the most important natural fire source. Its induced forest fire brings enormous losses to human beings and ecological environment. Many countries have paid great attention to the prediction of lightning-caused fire.

[Fire behavior of Mongolian oak leaves fuel bed under no-wind and zero-slope conditions. II. Analysis of the factors affecting flame length and residence time and related prediction models].

Taking fuel moisture content, fuel loading, and fuel bed depth as controlling factors, the fuel beds of Mongolian oak leaves in Maoershan region of Northeast China in field were simulated, and a total of one hundred experimental burnings under no-wind and zero-slope conditions were conducted in laboratory, with the effects of the fuel moisture content, fuel loading, and fuel bed depth on the flame length and its residence time analyzed and the multivariate linear prediction models constructed. The results indicated that fuel moisture content had a significant negative liner correlation with flame length, but less correlation with flame residence time. Both the fuel loading and the fuel bed depth were significantly positively correlated with flame length and its residence time.

[Fire behavior of ground surface fuels in Pinus koraiensis and Quercus mongolica mixed forest under no wind and zero slope condition: a prediction with extended Rothermel model].

A laboratory burning experiment was conducted to measure the fire spread speed, residual time, reaction intensity, fireline intensity, and flame length of the ground surface fuels collected from a Korean pine (Pinus koraiensis) and Mongolian oak (Quercus mongolica) mixed stand in Maoer Mountains of Northeast China under the conditions of no wind, zero slope, and different moisture content, load, and mixture ratio of the fuels. The results measured were compared with those predicted by the extended Rothermel model to test the performance of the model, especially for the effects of two different weighting methods on the fire behavior modeling of the mixed fuels. With the prediction of the model, the mean absolute errors of the fire spread speed and reaction intensity of the fuels were 0.

[Fire behavior of Mongolian oak leaves fuel-bed under no-wind and zero-slope conditions. I. Factors affecting fire spread rate and modeling].

Aimed to understand the fire behavior of Mongolian oak leaves fuel-bed under field condition, the leaves of a secondary Mongolian oak forest in Northeast Forestry University experimental forest farm were collected and brought into laboratory to construct fuel-beds with varied loading, height, and moisture content, and a total of 100 experimental fires were burned under no-wind and zero-slope conditions. It was observed that the fire spread rate of the fuel-beds was less than 0.5 m x min(-1).