Antiparasitic effect of (+)-catechin derived from Pseudolarix amabilis against Dactylogyrus intermedius in goldfish.

Medicinal plants are considered promising candidates for controlling parasitic pathogen in aquaculture. Our previous study demonstrated that the crude extracts of Pseudolarix amabilis exhibit promising anti-Dactylogyrus intermedius activity. However, the specific compounds responsible for the antiparasitic effects of these crude extracts remain elusive.

LncRNA432-miR-21-y-DAPK2 ceRNA crosstalk regulates antibacterial response in hypoxia stress through mediating mitochondrial apoptosis in teleost fish.

As cold-blooded vertebrates, fish are sensitive to environmental changes. The outcome of pathogen infections in fish therefore is highly shaped by hypoxia. The epigenetic regulation of competitive endogenous RNA (ceRNA) bridging non-coding RNAs and mRNAs represents a promising mechanism modulating antibacterial response plus environmental stress.

Advancements in the treatment of cerebral ischemia-reperfusion injury: Acupuncture combined with mesenchymal stem cells transplantation.

Cerebral ischemia-reperfusion injury (CIRI) constitutes a significant etiology of exacerbated cerebral tissue damage subsequent to intravenous thrombolysis and endovascular mechanical thrombectomy in patients diagnosed with acute ischemic stroke. The treatment of CIRI has been extensively investigated through a multitude of clinical studies. Acupuncture has been demonstrated to be effective in treating CIRI.

[Clinical Features and Prognosis of Patients with Primary Extranodal Diffuse Large B-Cell Lymphoma].

Objective: To investigate the clinical features, gene mutation profile, efficacy and prognostic factors of primary extranodal diffuse large B-cell lymphoma(EN-DLBCL).

Methods: A retrospective analysis was performed for 382 patients with primary EN-DLBCL with complete clinical data who were treated in West China Hospital from January 2013 to January 2023, and their clinical characteristics,gene mutation profile, efficacy and prognostic factors were analyzed.

Results: The median age of the 382 patients with EN-DLBCL was 56(18-89) years old.

Pressure-Induced Assembly of Organic Phase-Change Materials Hybridized with Expanded Graphite and Carbon Nanotubes for Direct Solar Thermal Harvesting and Thermoelectric Conversion.

Direct harvesting of abundant solar thermal energy within organic phase-change materials (PCMs) has emerged as a promising way to overcome the intermittency of renewable solar energy and pursue high-efficiency heating-related applications. Organic PCMs, however, generally suffer from several common shortcomings including melting-induced leakage, poor solar absorption, and low thermal conductivity. Compounding organic PCMs with single-component carbon materials faces the difficulty in achieving optimized comprehensive performance enhancement.

Type-B response regulator RRB12 regulates nodule formation in Lotus japonicus.

Background: The mutualistic beneficial relationship between legume plants and rhizobia enables the growth of plants in nitrogen-limiting conditions. Rhizobia infect legumes through root hairs and trigger nodule organogenesis in the cortex. The plant hormone cytokinin plays a pivotal role in regulating both rhizobial infection and the initiation of nodule development.

Potential of ultrasound stimulation and sonogenetics in vision restoration: a narrative review.

Vision restoration presents a considerable challenge in the realm of regenerative medicine, while recent progress in ultrasound stimulation has displayed potential as a non-invasive therapeutic approach. This narrative review offers a comprehensive overview of current research on ultrasound-stimulated neuromodulation, emphasizing its potential as a treatment modality for various nerve injuries. By examining of the efficacy of different types of ultrasound stimulation in modulating peripheral and optic nerves, we can delve into their underlying molecular mechanisms.

A Modification of the Ostergren Model for Thermomechanical Fatigue Life Prediction of Die-Casting Die Steel.

The Ostergren model is simple in form and widely used in engineering practice, also serving as the modeling basis of both the damage differentiation and crack propagation models. However, the shortcomings of the Ostergren model are that the modeling process is affected by thermomechanical fatigue (TMF) test parameters. To establish a TMF life normalized model, a modified Ostergren model based on hysteresis energy damage and TMF data for H13 steel was proposed.

Molecular insights into AGS3's role in spindle orientation: a biochemical perspective.

The intrinsic regulation of spindle orientation during asymmetric cell division depends on the evolutionarily conserved protein complex LGN (Pins)/NuMA (Mud)/Gα⋅GDP. While the role of LGN and its Drosophila orthologue Pins is well-established, the function of AGS3, the paralogue of LGN, in spindle orientation during cell division remains controversial. This study substantiates the contentious nature of AGS3's function through systematic biochemical characterizations.

Known and unknown: Exosome secretion in tumor microenvironment needs more exploration.

Exosomes, extracellular vesicles originating from endosomes, were discovered in the late 1980s and their function in intercellular communication has since garnered considerable interest. Exosomes are lipid bilayer-coated vesicles that range in size from 30 to 150 nm and appear as sacs under the electron microscope. Exosome secretion is crucial for cell-to-cell contact in both normal physiology and the development and spread of tumors.

High-frequency wearable ultrasound array belt for small animal echocardiography.

Wearable ultrasound has been widely developed for long-term, continuous imaging without the need for bulky system manipulation and repeated manual locating. To potentially lead to more accurate and reliable imaging monitoring, this work presents the design, fabrication, and evaluation of a novel high-frequency wearable ultrasound array belt (WUAB) for small animal echocardiography. The fabrication process involved precise dicing technology for a λ-pitch design.

Cell line-based models of normal and chronic bronchitis-like airway mucosa to study the toxic potential of aerosolized palladium nanoparticles.

Background: Physiologically relevant cell line-based models of human airway mucosa are needed to assess nanoparticle-mediated pulmonary toxicity for any xenbiotics expsoure study. Palladium nanoparticles (Pd-NP) originating from catalytic converters in vehicles pose health risks. We aimed to develop airway models to assess the toxic potential of Pd-NP in normal (Non-CB) and chronic bronchitis-like (CB-like) mucosa models.

Thin Zinc Electrodes Stabilized with Organobromine-Partnered HO-Zn-MeOH Cluster Ions for Practical Zinc-Metal Pouch Cells.

The utilization of thin zinc (Zn) anodes with a high depth of discharge is an effective strategy to increase the energy density of aqueous Zn metal batteries (ZMBs), but challenged by the poor reversibility of Zn electrode due to the serious Zn-consuming side reactions at the Zn||electrolyte interface. Here, we introduce 2-bromomethyl-1,3-dioxolane (BDOL) and methanol (MeOH) as electrolyte additive into aqueous ZnSO electrolyte. In the as-formulated electrolyte, BDOL with a strong electron-withdrawing group (-CHBr) tends to pair with the HO-Zn-MeOH complex, leading to the formation of organobromine-partnered HO-Zn-MeOH cluster ions.

Efficacy of photodynamic therapy combined with cross-punch technique for the treatment of keloid.

Objective: Keloids are characterized by abnormal activation of fibroblasts and excessive collagen deposition. Keloids are notoriously difficult to treat effectively due to their high recurrence rate after therapy. Our study explored the use of the punch technique in conjunction with photodynamic therapy, a novel approach that may swiftly reduce keloid volume, promote collagen remodeling, mitigate inflammation and enhance the wound healing process.

Senescent lung-resident mesenchymal stem cells drive pulmonary fibrogenesis through FGF-4/FOXM1 axis.

Background: Idiopathic pulmonary fibrosis (IPF) is an age-related disease featured with abnormal fibrotic response and compromised lung function. Cellular senescence is now considered as an essential driving mechanism for IPF. Given the poor knowledge of the mechanisms underpinning IPF progression, understanding the cellular processes and molecular pathways is critical for developing effective therapies of IPF.

Research on precise lithium battery state of charge estimation method based on CALSE-LSTM model and pelican algorithm.

This paper presents an innovative fusion model called "CALSE-LSTM," which integrates Convolutional Neural Networks (CNNs), Long Short-Term Memory Networks (LSTMs), self-attention mechanisms, and squeeze-and-excitation attention mechanisms to optimize the estimation accuracy of the State of Charge (SoC). The model incorporates battery historical data as input and employs a dual-attention mechanism based on CNN-LSTM to extract diverse features from the input data, thereby enhancing the model's ability to learn hidden information. To further improve model performance, we fine-tune the model parameters using the Pelican algorithm.