Publications by authors named "Ji In Kim"
Comparative crystal structure analysis of the human EP300 and CBP KIX domains.
Biochem Biophys Res Commun
December 2024
Small-cell lung cancer (SCLC) is highly lethal because the tumors grow and metastasize rapidly. Effective treatments for SCLC are lacking currently. A recent study demonstrated that the E1A binding protein P300 (EP300) KIX domain has pro-tumorigenic activity and is selectively involved in the development and growth of SCLC.
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- Extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase-producing bacteria are becoming a major global health issue due to their resistance to third-generation cephalosporins, particularly in food animals.
- A study conducted in South Korea collected 409 serovar Infantis isolates from various healthy and diseased food animals, revealing that 61.9% were resistant to ceftiofur, mainly from chickens, highlighting significant multidrug resistance patterns across the isolates.
- Molecular analysis indicated that all ceftiofur-resistant strains produced specific β-lactamase enzymes, with the majority belonging to sequence type ST32, suggesting widespread dissemination of resistance genes among food animal populations.
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- - The study investigated multidrug-resistant (MDR) Agona infections from food-producing animals in South Korea, specifically focusing on 209 isolates predominantly found in chickens, pigs, cattle, and ducks from 25 slaughterhouses between 2010 and 2020.
- - Findings revealed that chicken Agona isolates had a high resistance rate (69-83%) to several antibiotics and exhibited significantly greater levels of MDR compared to isolates from cattle and pigs.
- - Molecular analysis identified 23 types of Agona isolates, with two major types (P1-III-2-13 and P1-IV-2-13) being most prevalent, and a dominant sequence type (ST13) found primarily in chickens, indicating a potential public health
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- * Results showed that dogs had significantly higher resistance rates to various antimicrobials, with cefalexin (68.9%) being the most resistant, while both species showed low resistance to amikacin and imipenem.
- * A notable 42.3% of isolates exhibited multidrug resistance, higher in dogs (34.9%) than cats (20.9%), raising public health concerns about potential transmission of resistant strains to humans or other animals.
The association between migraine and Parkinson's disease: a nationwide cohort study.
Epidemiol Health
February 2024
Article Synopsis
- A study investigated the link between migraine and the risk of developing Parkinson's disease (PD) using data from the Korean National Health Insurance System.* -
- The research included over 214,000 patients with migraine and found that those with migraine had a 1.35 times higher risk of developing PD compared to those without migraine, despite a similar incidence between migraine patients with and without aura.* -
- The study concluded that managing comorbid conditions and chronic migraine may help reduce PD incidence, and further clinical trials are needed to clarify this relationship.*
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- Long-term studies on the effectiveness of arthroscopic repair for large subscapularis (SSC) tears are scarce, with this research evaluating both structural and clinical outcomes using MRI.
- The study included 109 patients with large SSC tears, assessing factors contributing to retear and overall outcomes after a follow-up period of over 7 years.
- Key findings revealed an SSC retear rate of 8.3%, with factors such as the size of the supraspinatus tear and the grade of fatty infiltration being significant predictors of poorer outcomes and higher retear rates in patients.
Site-specific soil ecological risk assessment is important for protecting soil ecosystems because it reflects the environmental factors at the site to detect ecological risks and develop risk management measures. This study assessed the ecological risks from chemical pollutants in abandoned mine sites using the TRIAD approach, evaluating its overall applicability, including the tiered system of assessment. A site-specific soil ecological risk assessment was conducted for five abandoned mine sites (Sites 1-4 and R, the reference site); integrated risks (IRs) for each site were calculated.
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- - The study focused on 3D printing dental resin-based composites (DRCs) with ceramic additives using digital light processing (DLP), aiming to enhance their mechanical strength and stability.
- - It tested two ceramic additives, carbon nanotubes (CNT) and yttria-stabilized zirconia (YSZ), to improve the DRCs' properties under environmental stress commonly faced in dental applications.
- - Results showed that DRCs with 0.5 wt.% YSZ had the best hardness (19.8 HRB) and flexural strength (50.6 MPa), while maintaining good oral rinsing stability, suggesting potential for improved dental materials.
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- Researchers improved the performance of a 100-TW Ti:Sapphire laser by correcting wavefront distortions that occurred during the post-compression process, resulting in a greater intensity output.
- The laser's pulse duration was significantly reduced from 24 femtoseconds (fs) to 11 fs by using multiple fused silica plates and chirped mirrors.
- By implementing an adaptive optics system to fix wavefront aberrations, the quality of the laser beam was enhanced, increasing the Strehl ratio from 0.37 to 0.52 and enhancing the focused intensity by 1.5 times compared to just a 1.1 times enhancement without correction.
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- The study investigates preventive health behaviors regarding the coronavirus pandemic among Korean young adults, focusing on the effects of risk perception variables like optimistic bias, hypochondriasis, and mass psychology.
- Results indicate that mass psychology positively influences preventive health behavior, with individuals exhibiting higher compliance in practices like mask-wearing and vaccination compared to those with lower mass psychology levels.
- The study highlights the importance of Korean collectivism and global fear of COVID-19 in shaping health behaviors, suggesting that mass psychology should guide future public health communication strategies.
Ecological risk assessment based on scientific data is crucial for understanding causal relationships between chemical pollution and environmental risks. Simultaneously, a balance is required between socioeconomic factors and scientific evidence. The TRIAD approach, which incorporates three lines of evidence (LoE)-chemical (Chem-LoE), ecotoxicological (Ecotox-LoE), and ecological (Eco-LoE)-was applied in five sites of an abandoned mine for site-specific soil ecological risk assessment (SERA).
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- Researchers achieved pulse generation under 10 femtoseconds (fs) by enhancing peak power from a 100 TW Ti:Sapphire laser through post-compression.* -
- The process involved broadening the laser spectrum using self-phase modulation in thin fused silica plates and compensating for the spectral phase with chirped mirrors.* -
- A spatial filter setup with lenses helped reduce intensity spikes, ultimately compressing the laser pulse from 23 fs to 9.7 fs, resulting in a 2.1 times increase in peak power.*
Article Synopsis
- * High concentrations of DDT were found in orchards, with some samples exceeding Canadian soil quality guidelines, indicating ongoing pesticide use and potential risks to soil health.
- * The research highlights the historical use of certain pesticides, using isomer ratios to differentiate between past and present pesticide application, which can inform future soil management policies in agricultural areas.
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- Traffic-related facilities generally emit less metal pollution than other sources, but their widespread presence can still contribute significantly to soil contamination.
- A study measured metal contamination in soils, revealing that concentrations of zinc (Zn), lead (Pb), and copper (Cu) were often higher than natural levels, with Zn being the most prevalent contaminant.
- The analysis identified two main sources of contamination: vehicle maintenance and emissions, categorizing pollution into different groups based on their origin, such as areas around garages and parking lots.
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- Research on targeting glucose metabolism in cancer has faced challenges due to ineffective anti-glycolytic agents and limited understanding of different cancer types' glucose use.
- A new compound, KL-11743, effectively inhibits class I glucose transporters, leading to decreased NADH levels and increased aspartate, indicating a shift to mitochondrial oxidative phosphorylation.
- The study found that mutations in key metabolic pathways make certain tumors, particularly SDHA-deficient cancers, more susceptible to GLUT inhibitors like KL-11743, showing potential for targeted cancer therapies.
Article Synopsis
- - A multispectral wavefront sensor was used to perform a single-shot spatiotemporal characterization of an ultrahigh intensity laser pulse.
- - The setup involved modulating a femtosecond laser pulse, separating it using a Fabry-Perot etalon with a grating pair, and measuring its spatio-spectral electric field.
- - The study revealed that spatiotemporal distortions can decrease the focused laser intensity by 15% compared to an ideal, diffraction-limited laser pulse.
Article Synopsis
- * Soil PFAS concentrations varied from 0.175 to 11.7 ng/g dry weight, with industrial complexes and landfills showing significantly higher median levels compared to other areas.
- * The predominant PFAS in the soils included PFOS, PFOA, and specific long-chain perfluorinated carboxylic acids, with notable concentrations in industrial areas, especially from textile and metal industries.
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- The study analyzes angular dispersion in a nanosecond optical parametric chirped-pulse amplification (ns-OPCPA) amplifier used in multi-PW laser systems.
- It identifies wavefront rotation as a significant factor contributing to angular dispersion, overshadowing the effects of pulse front tilt.
- Experimental validation of the theory was achieved through measurements taken from the ns-OPCPA frontend in a 20-fs, 4-PW Ti:Sapphire laser, highlighting the need to control angular dispersion to maintain focus intensity in ultrahigh power lasers.
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- - The study focuses on improving the classification accuracy of neuroimaging techniques in differentiating between Alzheimer's disease (AD), mild cognitive impairment (MCI) subtypes, and healthy controls (HC), using various neuroimaging modalities combined with genetic data.
- - Researchers utilized whole-brain parcelation analysis and voxel-wise analysis to extract features from neuroimaging data of 129 subjects, including AD, stable MCI, converting MCI, and healthy controls, all sourced from the Alzheimer's Disease Neuroimaging Initiative (ADNI).
- - The study aims to enhance analysis consistency and accuracy by exploring both graphical and region-based analyses across multiple binary classification groups, ultimately seeking better understanding and discrimination of neurodegenerative stages.
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- Aerobic glycolysis, discovered by Warburg as a key feature of cancer, is also involved in the activation and growth of immune cells.* -
- Glucose transporters (GLUTs) enable the transport of glucose across cell membranes and are potential targets for regulating aerobic glycolysis.* -
- The study focuses on developing and improving a new set of effective oral inhibitors that target GLUT1 and GLUT3, which could lead to new treatments for cancer and autoimmune diseases.*
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- In acute ischemic stroke, blood pressure initially rises but typically returns to baseline within 24-48 hours, with variability in outcomes based on when BP is measured post-stroke.
- A study of 446 patients showed that those with favorable outcomes (mRS score 0-2 at discharge) had lower systolic blood pressure at 12 and 24 hours after admission, along with better initial neurological assessments.
- Key predictors of favorable outcomes included lower initial NIH Stroke Scale scores, fewer neurological deficits, and lower SBP at 24 hours, regardless of whether patients received tPA treatment.
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- The authors identified a language error in their previously published article.
- They made a correction to the text to address this issue.
- Additionally, they replaced Figure 1 to enhance clarity or accuracy.
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- This study examined how thermotherapy affects gas pain, resilience after surgery, and body temperature discomfort in patients who had laparoscopic myomectomies.
- The experimental group received thermotherapy four hours post-surgery, while the control group did not, with data analyzed using various statistical methods.
- Results indicated that thermotherapy significantly reduced shoulder-related gas pain and body temperature discomfort, suggesting it could enhance post-operative recovery for patients undergoing laparoscopic surgeries.
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- A variety of in-vehicle infotainment (IVI) devices have been created, but there's a lack of research on efficiently managing these resources to enhance user experience.
- This paper proposes a new framework that introduces an 'IVI-Master' for overall control, categorizing users and resources to streamline management using Lightweight Machine-to-Machine (LWM2M) standards.
- Testing revealed that this IoT-based approach not only effectively handles IVI resources but also uses less bandwidth compared to traditional methods.
Jeju haenyeos who enter the sea without equipment to collect seafood while holding their breath have a unique culture; however, studies of their health are limited. This study, using an ethnographic approach, explores how Jeju haenyeos have managed and maintained their health. Snowball sampling yielded 15 participants between July and October 2016.
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