N6-methyladenosine regulators in hepatocellular carcinoma: investigating the precise definition and clinical applications of biomarkers.

Background: Accurately identifying effective biomarkers and translating them into clinical practice have significant implications for improving clinical outcomes in hepatocellular carcinoma (HCC). In this study, our objective is to explore appropriate methods to improve the accuracy of biomarker identification and investigate their clinical value.

Methods: Concentrating on the N6-methyladenosine (m6A) modification regulators, we utilized dozens of multi-omics HCC datasets to analyze the expression patterns and genetic features of m6A regulators.

A novel waveguide rod with acoustic black hole for acoustic emission signal enhancement and its performance.

As an essential auxiliary tool for acoustic emission (AE) detection, waveguide rods are widely used in testing situations where sensors cannot contact the specimens directly, such as high temperature, cryogenic, corrosion, radiation, etc. However, the AE signal attenuation in waveguide rod makes the risk of missing weak acoustic emission events in damage detection, which limits the application of waveguide rods. Therefore, in this work, a novel waveguide rod was presented based on acoustic black hole (ABH) theory to enhance the AE signal before reaching the sensor through the energy convergence effect of the ABH.

Transformation and environmental chemical characteristics of hazardous trace elements in an 800 t/d waste incineration thermal power plant.

The hazardous trace elements (HTEs) emitted during the municipal solid waste incineration (MSWI) process have been widely concerned. In this work, the bottom ash (BA), heat recovery boiler ash (HA), and ash after desulfurization (SA) were collected to explore the occurrence forms of HTEs in the three types of ash and their relationship with minerals and leaching characteristics. The results show that the volatility of the seven studied HTEs follows the order of Cd, As > Ni, Zn > Pb > Cr, Cu.

A soft, bioinspired artificial lymphatic system for interactive ascites transfer.

Low-flow removal of refractory ascites is critical to treating cirrhosis and digestive system tumor, and thus, commercial ascites pump emerged lately. The rigid structure of clinically available pumps rises complication rate and lack of flow rate monitoring hinders early warning of abnormalities. Herein, a soft artificial system was proposed inspired by lymph for interactive ascites transfer with great biocompatibility.

M1 polarization of chicken macrophage HD11 can be activated by duck Tembusu virus via MyD88-NF-κB-mediated signaling pathway.

Duck Tembusu virus (DTMUV) has caused significant economic losses to the global duck industry since its outbreak in 2010. The macrophages act as the key immune cell, and its polarization in different functional states is very important for host's immune responses and microbial infections. Avian macrophages are the main target cells of DTMUV, its polarization induced by DTMUV and the underlying mechanisms were explored in this study.

Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.

Objectives: Oral squamous cell carcinoma (OSCC) is often diagnosed with cervical lymph node metastasis. Mesenchymal stem cells (MSCs) and interleukin-6 (IL-6) signalling are considered to play important roles in promoting tumour malignancy. The detailed biological interaction of MSCs and IL-6 and the subsequent effect on OSCC metastasis remain largely unclear.

Specific and Long-Term Luminescent Monitoring of Hydrogen Peroxide in Tumor Metastasis.

Luminescent monitoring of endogenous hydrogen peroxide (H O ) in tumors is conducive to understanding metastasis and developing novel therapeutics. The clinical transformation is obstructed by the limited light penetration depth, toxicity of nano-probes, and lack of long-term monitoring modes of up to days or months. New monitoring modes are introduced via specific probes and implantable devices, which can achieve real-time monitoring with a readout frequency of 0.

Effect of Stacking Sequence on Fatigue Performance of CFRP-Al Single-Lap Adhesive Joints: Experimental Study.

This study aimed to explore failure mechanisms of carbon fibre-reinforced plastic (CFRP)-aluminium (Al) single-lap adhesive joints which CFRP adherends had different stacking sequences. These results showed that fatigue performance of CFRP decreased as the number of 45° plies increased, which caused the initial failure location to gradually move from the adhesive layer towards the CFRP. Under high load levels, joint-failure models were influenced by the stacking sequence of CFRP; large-area cohesive failure occurred in joints when the CFRP stacking sequence was [0/90] and [0/45/-45/90], and delamination failure occurred when the CFRP stacking sequence was [45/-45], due to the weak interlaminar properties of CFRP.

Effects of an Intermittent Fasting 5:2 Plus Program on Body Weight in Chinese Adults with Overweight or Obesity: A Pilot Study.

To retrospectively review the efficacy of intermittent fasting 5:2 plus program (30% of energy requirements on fast days and 70% of energy requirements on nonfasting days) in Chinese patients with overweight or obesity. This retrospective cohort study evaluated weight loss outcomes of patients treated with 12 weeks weight loss program in clinic. Adults with overweight or obesity participated in intermittent fasting 5:2 plus, daily calorie restriction (70% of energy requirements every day) or daily calorie restriction with meal replacement (70% of energy requirements every day, partly provided with high-protein meal replacement) programs for 12 weeks.

Nutrition Risk Screening and Related Factors Analysis of Non-hospitalized Cancer Survivors: A Nationwide Online Survey in China.

Purposes: This study investigated the nutritional problems and risks of Chinese non-hospitalized cancer survivors through an online survey.

Methods: The survey included nutritional and clinical questions distributed to non-hospitalized cancer survivors. All data were screened and analyzed with strict quality control.

Study on the Influence of Reinforced Particles Spatial Arrangement on the Neutron Shielding Performance of the Composites.

Particle-reinforced composites are widely applied as nuclear radiation shielding materials for their excellent comprehensive properties. The work aimed to calculate the influence of the functional reinforced particles spatial arrangement on the neutron shielding performance of composites and attempted to explain the influence mechanism by investigating the neutron flux distribution in the materials. Firstly, four suitable physical models were established based on the Monte Carlo Particle Transport Program (MCNP) and mathematical software MATLAB, namely the RSA (Random Sequential Adsorption) Model with particles random arrangement and FCC Model, BCC Model and Staggered Arrangement Model (SA Model) with particle periodic arrangements.

Extracting clinical named entity for pituitary adenomas from Chinese electronic medical records.

Objective: Pituitary adenomas are the most common type of pituitary disorders, which usually occur in young adults and often affect the patient's physical development, labor capacity and fertility. Clinical free texts noted in electronic medical records (EMRs) of pituitary adenomas patients contain abundant diagnosis and treatment information. However, this information has not been well utilized because of the challenge to extract information from unstructured clinical texts.

Flexible Dual-Channel Digital Auscultation Patch With Active Noise Reduction for Bowel Sound Monitoring and Application.

Bowel sounds (BSs) have important clinical value in the auxiliary diagnosis of digestive diseases, but due to the inconvenience of long-term monitoring and too much interference from environmental noise, they have not been well studied. Most of the current electronic stethoscopes are hard and bulky without the function of noise reduction, and their application for long-term wearable monitoring of BS in noisy clinical environments is very limited. In this paper, a flexible dual-channel digital auscultation patch with active noise reduction is designed and developed, which is wireless, wearable, and conformably attached to abdominal skin to record BS more accurately.

Flexible Doppler ultrasound device for the monitoring of blood flow velocity.

Thrombosis and restenosis after vascular reconstruction procedures may cause complications such as stroke, but a clinical means to continuously monitor vascular conditions is lacking. Conventional ultrasound probes are rigid, particularly for postoperative patients with fragile skin. Techniques based on photoplethysmography or thermal analysis provide only relative changes in flow volume and have a shallow detection depth.

A flexible, stretchable system for simultaneous acoustic energy transfer and communication.

The use of implantable medical devices, including cardiac pacemakers and brain pacemakers, is becoming increasingly prevalent. However, surgically replacing batteries owing to their limited lifetime is a drawback of those devices. Such an operation poses a risk to patients—a problem that, to date, has not yet been solved.

Prevalence of malnutrition/malnutrition risk and nutrition-related risk factors among patients with Parkinson's disease: systematic review and meta-analysis.

Introduction: The clinical symptoms and nutritional status of patients with Parkinson's disease (PwP) are interrelated, and the clinical outcomes in malnourished patients are often poor. Only a few studies have reviewed the prevalence of malnutrition and nutrition-related risk factors in PwP.

Objective: To explore the prevalence of malnutrition/ malnutrition risk among PwP, and estimate nutrition-related risk factors.

Self-expanding metal stent insertion by colorectal surgeons using a two-person approach colonoscopy without fluoroscopic monitoring in the management of acute colorectal obstruction: a 14-year experience.

Background: Placement of a self-expanding metal stent (SEMS) in patients presenting with an acute colorectal obstruction (ACO) may obviate emergency surgery (ES), potentially effectively palliating incurable tumors, acting as a bridge to surgery (BTS) in patients with operable or potentially operable tumors and achieving effective decompression of other ACO. We present our experience with SEMS insertion by colorectal surgeons without fluoroscopic monitoring for ACO especially for acute malignant colorectal obstruction (AMCO) for nearly a 14-year period (2007-2020).

Aim: To explore the safety and effectiveness of SEMS insertion in the management of ACO by colorectal surgeons using a two-person approach colonoscopy without fluoroscopic monitoring.

Rectovaginal Fistula With Double Vagina and Anastomotic Stenosis: A Case Report Following Rectal Cancer Surgery.

Rectovaginal fistula (RVF) occurs as a result of abnormal epithelialized connections between the rectum and vagina. Rectal cancer surgery remains the major cause of RVF. Here, we report a rare postoperative complication in which a patient with a double uterine and vagina received RVF following rectal cancer surgery.

Identifying genes for resistant starch, slowly digestible starch, and rapidly digestible starch in rice using genome-wide association studies.

Background: The digestibility of starch is important for the nutritive value of staple food. Although several genes are responsible for resistant starch (RS) and slowly digestible starch (SDS), gaps persist concerning the molecular basis of RS and SDS formation due to the complex genetic mechanisms of starch digestibility.

Objectives: The objective of this study was to identify new genes for starch digestibility in rice and interprete the genetic mechanisms of RS and SDS by GWAS.

Periostin aggravates NLRP3 inflammasome-mediated pyroptosis in myocardial ischemia-reperfusion injury.

Pyroptosis is a form of caspase-1-induced programmed cell death. This study aimed to investigate the effect of periostin (postn) on pyroptosis in myocardial ischemia-reperfusion injury (MIRI). To this end, the differentially expressed genes were obtained from the GSE4105 dataset using the "GEO2R" online tool.

Misdiagnosis of multiple synchronous small bowel adenocarcinomas as intestinal tuberculosis: a case report.

Background: Small bowel adenocarcinoma (SBA) is a rare malignancy that primarily occurs in the duodenum. Multiple synchronous SBA is unique rare and difficult to diagnose due to non-specific disease presentation. Protocols to identify multiple synchronous SBA during early disease stages are urgently required.

Diffuse leptomeningeal glioneuronal tumour (DLGNT) with hydrocephalus as an initial symptom: a case-based update.

Purpose: Diffuse leptomeningeal glioneuronal tumour (DLGNT) is a rare disease classified in 2016. There are different views of the clinical, pathologic and neuroradiologic characteristics of DLGNT due to the minor studies on this disease.

Methods: We describe a case of a 12-year-old boy who initially presented intermittent headache, vomiting and communicating hydrocephalus.

Modal identification of a high-rise building subjected to a landfall typhoon via both deterministic and Bayesian methods.

Modal identification involves primarily the determination of natural frequencies, damping ratios, mode shapes of a dynamic system, etc. It is usually regarded as an essential task in a wide branch of structural dynamics and civil engineering, such as structural vibration control and damage identification of buildings or bridges. There are many modal identification techniques.