Publications by authors named "Ji Chun Chen"
Article Synopsis
- This study examined the link between fruit and vegetable consumption and arterial stiffness in a large group of participants (6,628) over a significant period (2007-2021).
- Results indicated that increasing fruit and vegetable intake by 100 grams daily was associated with a reduction in arterial stiffness measured by the arterial velocity-pulse index (AVI).
- Maintaining a high intake of fruits and vegetables (≥ 500 g/day) was shown to lower the risk of elevated arterial stiffness over the 11.5-year follow-up period, supporting dietary recommendations for better cardiovascular health.
Background: The benefits of healthy lifestyles are well recognized. However, the extent to which improving unhealthy lifestyles reduces cardiovascular disease (CVD) risk needs to be discussed. We evaluated the impact of lifestyle improvement on CVD incidence using data from the China-PAR project (Prediction for Atherosclerotic Cardiovascular Disease Risk in China).
View Article and Find Full Text PDFBackground: Candida auris is an opportunistic pathogen with multiple drug resistance. Therefore, researchers conducted a meta-analysis to review PCR's ability to diagnose Candida auris to promote the development of accurate Candida auris diagnosis.
Methods: Researchers systematically retrieved relevant articles from PubMed, Cochrane Library, Embase, and Web of Science.
Metabolomics study of blood pressure salt-sensitivity and hypertension.
Nutr Metab Cardiovasc Dis
July 2022
Background And Aims: Identify novel metabolite associations with blood pressure (BP) salt-sensitivity and hypertension.
Methods And Results: The Genetic Epidemiology Network of Salt Sensitivity (GenSalt) Replication study includes 698 Chinese participants who underwent a 3-day baseline examination followed by a 7-day low-sodium feeding and 7-day high-sodium feeding. Latent mixture models identified three trajectories of blood pressure (BP) responses to the sodium interventions.
Background: Tuberculosis poses a severe threat to human health. At present, compared with the traditional diagnostic methods for tuberculosis pleural effusion, such as Löwenstein-Jensen culture, pleural biopsy, and Ziehl-Neelsen smear microscopy, Xpert MTB/RIF was regarded as an emerging technology for its efficiency. The Xpert MTB/RIF accuracy for tuberculous pleural effusion diagnosis was evaluated in this systematic study.
View Article and Find Full Text PDFIntroduction: Staphylococcus aureus is a gram-positive bacterium that causes serious infection. With the increasing resistance of bacteria to current antibiotics, it is necessary to learn more about the molecular mechanism and cellular pathways involved in the Staphylococcus aureus infection.
Methods: We downloaded the GSE33341 dataset from the GEO database and applied the weighted gene co-expression network analysis (WGCNA), from which we obtained some critical modules.
COVID-19 is a serious infectious disease that has recently swept the world, and research on its causative virus, SARS-CoV-2, remains insufficient. Therefore, this study uses bioinformatics analysis techniques to explore the human digestive tract diseases that may be caused by SARS-CoV-2 infection. The gene expression profile data set, numbered GSE149312, is from the Gene Expression Omnibus (GEO) database and is divided into a 24-h group and a 60-h group.
View Article and Find Full Text PDFObjectives: Moderate to vigorous physical activity is recommended to prevent hypertension according to the current guidelines. However, the degree to which the total physical activity (TPA) and its changes benefit normotensives and hypertensives is uncertain. We aimed to examine the effects of TPA and its changes on the incidence, progression, and remission of hypertension in the large-scale prospective cohorts.
View Article and Find Full Text PDFArticle Synopsis
- This study explored the link between soybean product consumption and the risk of developing hypertension in a large group of Chinese adults.
- Researchers divided participants into two groups based on their consumption levels (≥ 125 g/day considered "ideal") and found that those in the ideal group had a significantly lower risk of hypertension.
- The findings suggest that incorporating more soybean products in the diet may help lower blood pressure and reduce hypertension risk, highlighting potential public health benefits for hypertension prevention.
Background: The association of milk intake with cardiovascular disease (CVD) and cause-specific mortality remained controversial and evidence among the Chinese population was limited. We aimed to study the relationship between milk intake and CVDs among general Chinese adults.
Methods: A total of 104,957 participants received questionnaire survey.
Background: In China, lack of evidence remains a significant challenge for the national initiative to promote physical activity (PA). We aimed to quantify the beneficial effects of meeting or maintaining the recommended PA level [150 minutes per week (min/wk) of moderate PA or 75 min/wk of vigorous PA or an equivalent combination] on incident cardiovascular disease (CVD) among Chinese population.
Methods: We included 100,560 participants without history of CVD from three cohorts in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project.
Prevalence of active and passive tobacco smoking among Beijing residents in 2011.
Chronic Dis Transl Med
June 2016
Objectives: This study was aimed to investigate the prevalence of active and passive tobacco smoking among Beijing residents in 2011.
Methods: A cross-sectional survey was conducted, using a stratified multistage cluster random sampling method to select a representative sample of 20,242, among Beijing residents aged 18-79 years. Active and passive tobacco smoking information was collected by a standardized and validated questionnaire in a face-to-face interview.
Risk stratification of atherosclerotic cardiovascular disease in Chinese adults.
Chronic Dis Transl Med
June 2016
Objective: This study aims to determine the distribution of observed atherosclerotic cardiovascular disease (ASCVD) incidence in contemporary cohorts in China, and to identify cut-off points for ASCVD risk classification based on traditional criteria and new equations developed by Prediction for ASCVD Risk in China (China-PAR).
Methods: The study populations included cohorts in the China-PAR project, with 34,757 participants eligible for the current analysis. Traditional risk stratification was assessed by using Chinese guidelines on prevention of CVD and hypertension, and 5 risk groups were classified based on these guidelines after slight modification for available risk factors.
Objective: Urinary excretion of angiotensinogen [urine angiotensinogen (UAGT)] has been proposed as a biomarker of intrarenal renin-angiotensin system activity. We investigated the association between UAGT and salt-sensitivity and potassium-sensitivity of blood pressure (BP) among Genetic Epidemiology Network of Salt Sensitivity study participants.
Methods: The intervention consisted of a 7-day low-sodium diet (51.
Objective: To investigate the association between physical activity (PA) and the incidence of metabolic syndrome (MS) in Chinese adults.
Methods: Data on PA and other variables were obtained at the baseline examination of China Multi-center study of Cardiovascular Epidemiology in 1998 and of International Collaborative study of Cardiovascular Disease in Asia(InterASIA) during 2000 - 2001. Follow-up study was conducted in 2007 - 2008.
Blood pressure responses to dietary sodium and potassium interventions vary among individuals. We studied the long-term reproducibility of blood pressure responses to dietary sodium and potassium intake. We repeated the dietary sodium and potassium interventions among 487 Chinese adults 4.
View Article and Find Full Text PDFSalt sensitivity of blood pressure (BP) is influenced by genetic and environmental factors. A dietary feeding study was conducted from October 2003 to July 2005 that included a 7-day low-sodium intervention (51.3 mmol sodium/day) followed by a 7-day high-sodium intervention (307.
View Article and Find Full Text PDFBackground: Increased blood pressure and elevated total cholesterol (TC) level are the two most important modifiable risk factors of cardiovascular disease (CVD) in the world. Hypertension and hypercholesterolemia co-exist more often than would be expected and whether there is a synergistic impact on fatal CVD between elevated TC and hypertension need to be further examined in Chinese population.
Methods: We conducted a cohort study which recruited 5092 Chinese male steelworkers aged 18 - 74 years in 1974 - 1980 and followed up for an average of 20.
Objective: Observational epidemiologic studies and clinical trials have documented that dietary potassium intake lowers blood pressure (BP). We examined the association between genetic variants in the renin-angiotensin-aldosterone system and BP responses to potassium intervention.
Methods: A 7-day high-sodium followed by a 7-day high-sodium plus 60 mmol/day potassium-supplementation feeding study was conducted among 1906 participants from rural northern China.
Objective: To examine the association between renin-angiotensin-aldosterone system (RAAS) genes and salt sensitivity of blood pressure (BP).
Methods: A 7-day low-sodium dietary intervention followed by a 7-day high-sodium dietary intervention was conducted among 1906 participants living in a rural region of north China where habitual sodium intake is high. BP measurements were obtained at baseline and following each intervention using a random-zero sphygmomanometer.
Article Synopsis
- A study was conducted on 169,871 Chinese adults aged 40 and older to examine the relationship between BMI and stroke incidence and mortality, finding that higher BMI is linked to a greater risk of strokes.
- Data was collected in 1991 and followed up in 1999-2000, with 7,489 strokes recorded over an average of 8.3 years of follow-up.
- The research revealed that underweight individuals had a lower risk of stroke compared to normal weight, while overweight and obese individuals had significantly higher risks for both types of strokes and for stroke-related death.
Background: Hypertension is a major global-health challenge because of its high prevalence and concomitant risks of cardiovascular disease. We estimated premature deaths attributable to increased blood pressure in China.
Methods: We did a prospective cohort study in a nationally representative sample of 169,871 Chinese adults aged 40 years and older.