Publications by authors named "Ji Ah Kim"

A 31-year-old woman presented with intermittent otalgia in the right ear, reporting severe pain during flights. The patient denied performing habitual Valsalva maneuvers. Otoendoscopic examination revealed hyperectatic herniation of the posterior portion of the right tympanic membrane (TM).

View Article and Find Full Text PDF
Article Synopsis
  • Autoinhibition is a key self-regulation mechanism in cell signaling that ensures signals only pass through in the presence of specific inputs, making autoinhibited proteins relevant in human diseases as potential targets for therapy.
  • The newly established Autoinhibited Protein Database (AiPD) compiles standardized information on autoinhibited proteins, including details on autoinhibitory domains, their targets, and their roles in diseases.
  • AiPD features a significant collection of both experimentally characterized and computationally predicted autoinhibited proteins, making it a crucial resource for researchers focusing on autoinhibition mechanisms and drug discovery.
View Article and Find Full Text PDF
Article Synopsis
  • Bulbar dysfunction in ALS negatively impacts daily life, causing issues like weight loss and shorter survival rates, with existing evaluation methods lacking Korean-specific tools.* -
  • This study developed and validated the Korean version of the Center for Neurologic Study Bulbar Function Scale (K-CNS-BFS) to assess bulbar dysfunction in Korean ALS patients.* -
  • The K-CNS-BFS demonstrated strong reliability and validity, effectively measuring bulbar dysfunction and correlating well with established ALS assessments.*
View Article and Find Full Text PDF

Purpose: The aim of this study was to investigate the mediating effects of health literacy on the relationship between frailty and health-related quality of life (HRQOL) among community-dwelling older adults.

Methods: This study used the Korean Frailty and Aging Cohort Database (KFACD) for secondary data analysis. We selected data from 1,631 people without missing main variable values for analysis.

View Article and Find Full Text PDF

, a perennial crop in the family, is one of Korea's representative forest medicinal plants. However, the growing area of has been reduced by plant disease and soil sickness caused by fusarium wilt. This study isolated rhizosphere bacteria from , and their antagonistic activity was evaluated against Particularly, four isolated strains, namely, PT1, ST7, ST8, and SP4, showed a significant antagonistic activity against .

View Article and Find Full Text PDF

Myopia is one of the risk factors for glaucoma, making accurate diagnosis of glaucoma in myopic eyes particularly important. However, diagnosis of glaucoma in myopic eyes is challenging due to the frequent associations of distorted optic disc and distorted parapapillary and macular structures. Macular vertical scan has been suggested as a useful tool to detect glaucomatous retinal nerve fiber layer loss even in highly myopic eyes.

View Article and Find Full Text PDF

Purpose: The purpose of this study was to report a case with bilateral paravascular inner retinal defects (PIRDs) enlarging with progressive myopia, which had different structural characteristics from the glaucomatous retinal nerve fiber layer (RNFL) defect.

Patients And Methods: A 10-year-old girl with high myopia was referred to a glaucoma clinic for evaluation of RNFL defects shown in color fundus photographs. Fundus photographs and optical coherence tomography examinations were serially reviewed to examine the changes in the RNFL.

View Article and Find Full Text PDF

Although central retinal artery occlusion (CRAO) has its own defining pathomechanism and clinical characteristics, morphologic feature of the optic nerve head (ONH) during its later stage is not diagnostic, which makes it difficult to differentiate CRAO from other optic neuropathies. This cross-sectional study was performed to investigate the differences in the topographic morphology of the ONH in eyes with normal-tension glaucoma (NTG) and CRAO. Thirty-one eyes with NTG; 31 eyes with CRAO; and 31 healthy fellow eyes of the subjects with CRAO were included.

View Article and Find Full Text PDF

Background/aims: To investigate the influence of peripapillary retinoschisis (PRS) on visual field (VF) test results in patients with primary open angle glaucoma (POAG).

Methods: Thirty eyes of 30 patients with POAG who had PRS at least once were included. All eyes were followed-up for a minimum 5 years at 4-6-month intervals.

View Article and Find Full Text PDF

A number of studies have proposed an inverse association between allergic diseases and risk of cancer, but only a few studies have specifically investigated the risk of primary liver cancer, including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The aim of this study was to evaluate the association of allergic diseases with risk of primary liver cancer. We conducted a retrospective cohort study of the Korean National Health Insurance Service database consisted of 405,512 Korean adults ages 40 and above who underwent health screening before January 1st, 2005.

View Article and Find Full Text PDF

Purpose: To compare the microvasculature of the optic nerve head (ONH) and peripapillary tissues in eyes with normal-tension glaucoma (NTG) and nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCTA).

Methods: Thirty-eight eyes with treatment-naïve NTG, 38 eyes with NAION matched for retinal nerve fiber layer (RNFL) thickness in each superior and inferior quadrant, and 38 healthy eyes matched by age were included. ONH and peripapillary retinal microvasculature was evaluated in en face images obtained using OCTA.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to explore the link between corneal refractive surgery and glaucoma prevalence in Koreans.
  • Data from the Korea National Health and Nutrition Examination Survey (KNHANES) was analyzed, including 604 post-surgery eyes and 3389 control eyes, with glaucoma diagnosed based on international criteria.
  • Results indicated that while glaucoma rates were similar between the two groups, corneal refractive surgery was found to significantly increase glaucoma risk, except when looking solely at eyes with higher degrees of myopia, where no association was found.
View Article and Find Full Text PDF

Purpose: To determine the prognostic significance of choroidal microvasculature dropout (MvD) to predict the future rate of progressive retinal nerve fiber layer (RNFL) thinning in eyes with primary open-angle glaucoma (POAG).

Design: Prospective, longitudinal case series.

Participants: This study enrolled 101 eyes of 101 patients with POAG who underwent OCT angiography (OCTA) imaging of the optic nerve head at baseline and were followed up for at least 2 years thereafter, during which RNFL thickness was measured by serial spectral-domain OCT.

View Article and Find Full Text PDF

Background/aims: To investigate whether parapapillary choroidal microvasculature dropout (MvD) is associated with progressive retinal nerve fibre layer (RNFL) thinning in eyes with primary open-angle glaucoma (POAG) and disc haemorrhage (DH).

Methods: Parapapillary microvasculature was evaluated by swept-source optical coherence tomography (OCT) angiography (OCTA) in 50 eyes with POAG and DH, 1 year before, at the time of and 1 year after the detection of DH. MvD was defined as an area in the parapapillary deep layer of focal sectoral dropout with no visible microvascular network.

View Article and Find Full Text PDF

Purpose: To characterize peripapillary choroidal microvasculature dropout (MvD) in patients with compressive optic neuropathy (CON) as compared with those with open-angle glaucoma (OAG) using OCT angiography (OCTA).

Design: Cross-sectional, observational study.

Participants: Eighty-eight eyes of 44 patients with CON; 88 eyes of 88 patients with OAG matched by age, spherical error, and OCT-determined retinal nerve fiber layer thickness (RNFLT); and 88 eyes of 44 control participants matched by age and spherical error.

View Article and Find Full Text PDF

Purpose: To compare lamina cribrosa (LC) morphology in patients with normal tension glaucoma (NTG) and autosomal-dominant optic atrophy (ADOA).

Methods: This cross-sectional study matched 24 patients diagnosed with ADOA (24 eyes) by age and retinal nerve fiber layer thickness with 48 patients diagnosed with NTG (48 eyes) by age with 48 healthy controls (48 eyes). Optic nerve heads were scanned by enhanced-depth imaging (EDI) optical coherence tomography (OCT).

View Article and Find Full Text PDF

Purpose: To characterize differences in the lamina cribrosa (LC) morphology between healthy, ocular hypertension (OHT), and naive normal-tension glaucoma (NTG) eyes.

Methods: Each group consisted of 80 eyes of 80 participants who were matched for age, sex, and axial length. The participants underwent enhanced-depth-imaging volume scanning of the optic nerve head using spectral-domain optical coherence tomography.

View Article and Find Full Text PDF

Background: To describe factors affecting the prognosis after operation for recurrent intermittent exotropia (X[T]) in children.

Methods: Clinical records of 50 patients who underwent operation for recurrent X(T) by a single surgeon were reviewed. The age at diagnosis of X(T), and first and second operations, deviation angle at distance and near, surgical method, concurrent vertical strabismus, stereoacuity, and Worth's Four Dot (W4D) examination before reoperation were analyzed, along with the postoperative deviation angle.

View Article and Find Full Text PDF

Purpose: To determine which groupings of prognostic factors best explain the rapid progressive retinal nerve fiber layer (RNFL) thinning in patients with primary open-angle glaucoma (POAG).

Methods: Optic nerves of 111 POAG patients who were followed for at least 2.5 years, during which the RNFL thickness was measured by serial spectral-domain optical coherence tomography (OCT) were included.

View Article and Find Full Text PDF

Importance: Parapapillary choroidal microvasculature dropout (MvD) is considered one of pathophysiological manifestations of glaucomatous damage.

Objective: To evaluate the longitudinal change in the parapapillary choroidal MvD in patients with primary open-angle glaucoma (POAG), and to determine whether this change is associated with progressive retinal nerve fiber layer (RNFL) thinning.

Design, Setting, And Participants: This prospective observational case series was conducted at a tertiary referral center in Korea and included 68 patients with POAG who exhibited parapapillary choroidal MvD in en face optical coherence tomography (OCT) angiography (OCTA) images who were enrolled from the ongoing Investigating Glaucoma Progression Study from January 1, 2016, through July 31, 2018.

View Article and Find Full Text PDF

Background/aims: To investigate the relationship between the lamina cribrosa (LC) curvature and the microvasculature within the LC in treatment-naïve eyes with normal-tension glaucoma (NTG) and in healthy eyes.

Methods: Forty-one eyes with treatment-naïve NTG and 41 age and sex-matched healthy control eyes were included. The optic nerve head (ONH) area was scanned using spectral-domain optical coherence tomography (OCT) to examine the LC curvature quantified as the LC curvature index (LCCI).

View Article and Find Full Text PDF

Purpose: To document the development of disc torsion.

Methods: Consecutive disc photographs obtained at an interval of at least 1 year were reviewed retrospectively in 173 eyes of 173 Korean children. The angle of the vertical disc axis (AVDA) was measured in each fundus photograph with the fovea-disc center axis set at 0°.

View Article and Find Full Text PDF

Purpose: To compare regional variations in lamina cribrosa (LC) curvature and depth between healthy eyes (group 1) and naïve eyes with primary open-angle glaucoma (POAG) having superior (group 2), inferior (group 3), and both (group 4) hemifield retinal nerve fiber layer (RNFL) defects.

Design: Cross-sectional study.

Participants: Each group consisted of 39 eyes of 39 Korean patients who were matched for age, sex, and axial length.

View Article and Find Full Text PDF

Cataract is one of the most common geriatric diseases, and surgery is known to be the best treatment. Despite the increasing demand for cataract surgery, the opportunity for novice residents to practice cataract surgery is gradually diminishing as the patient and animal ethics become strict. Therefore, there have been many attempts to overcome the lack of experience by using virtual reality training system.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionj3o7flgcc6po0efnj6ev1u9g8httk1vs): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once