Copper-Catalyzed Synthesis of Pyrrolo[1,2-]quinazolines and Pyrrolo[2,1-]isoquinolines and Antiplasmodial Evaluation.

Reactions involving C(sp)-H bonds of azaarenes have been widely studied in recent years as they allow direct functionalization of these -heterocycles without the use of harsh reaction conditions. In this work, we describe the C(sp)-H functionalization of 4-methylquinazolines and 1-benzylisoquinolines, employing α-substituted β-nitrostyrenes catalyzed by inexpensive copper acetate. Under the optimized condition, 21 pyrrolo[1,2-]quinazolines, as well as an imidazo[1,2-]quinazoline and 4 pyrrolo[2,1-]isoquinolines, were obtained in moderate to good yields.

Greener organic synthetic methods: Sonochemistry and heterogeneous catalysis promoted multicomponent reactions.

Ultrasound is an essential technique to improve organic synthesis from the point of view of green chemistry, as it can promote better yields and selectivities, in addition to shorter reaction times when compared to the conventional methods. Heterogeneous catalysis is another pillar of sustainable chemistry being the recycling and reuse of the catalysts one of its great advantage. In the other hand, multicomponent reactions provide the synthesis of structurally diverse compounds, in a one-pot fashion, without isolation and purification of intermediates.