On resin synthesis of phosphoethanolamine cellulose.

Phosphoethanoamine (pEtN) cellulose is a chemically modified cellulose present in some bacterial biofilms. To deepen our understanding of this biopolymer and its biological function, access to chemically defined pEtN-cellulose oligosaccharides is desirable. Herein, we report an on resin protocol for the fast synthesis of tailor-made pEtN-celluloses.

Synthetic phosphoethanolamine-modified oligosaccharides reveal the importance of glycan length and substitution in biofilm-inspired assemblies.

Bacterial biofilm matrices are nanocomposites of proteins and polysaccharides with remarkable mechanical properties. Efforts understanding and tuning the protein component have been extensive, whereas the polysaccharide part remained mostly overlooked. The discovery of phosphoethanolamine (pEtN) modified cellulose in E.

On resin synthesis of sulfated oligosaccharides.

Sulfated glycans are involved in many biological processes, making well-defined sulfated oligosaccharides highly sought molecular probes. These compounds are a considerable synthetic challenge, with each oligosaccharide target requiring specific synthetic protocols and extensive purifications steps. Here, we describe a general on resin approach that simplifies the synthesis of sulfated glycans.

Selectively Targeting and Differentiating Vancomycin-Resistant Dual Synthetic Fluorescent Probes.

Many bacteria are pathogenic and harmful to humans. Noticeably, some , including vancomycin-resistant (VRSA), have become notoriously resistant to antibiotics and have spread rapidly, becoming threats to public health. Here, we designed a dual fluorescent probe scheme combining siderophores and antibiotics as the guiding units to selectively target VRSA and vancomycin-sensitive (VSSA) in complex bacterial samples.