Selenylated Imidazo [1,2-]pyridine Induces Apoptosis and Oxidative Stress in 2D and 3D Models of Colon Cancer Cells.

Colon cancer incidence rates are increasing annually, a scenario aggravated by genetic and epigenetic alterations that promote drug resistance. Recent studies showed that novel synthetic selenium compounds are more efficient and less toxic than conventional drugs, demonstrating biocompatibility and pro-oxidant effects on tumor cells. This study aimed to investigate the cytotoxic effect of MRK-107, an imidazo [1,2- ]pyridine derivative, in 2D and 3D cell culture models of colon cancer (Caco-2 and HT-29).